1,1'-(丁烷-1,4-二基)双(3-(3-异硫氰酸苯)硫脲)
更新时间：2026-03-19 12:08:28
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| 常用名 | N,N''-1,4-丁烷二基双[N'-(3-异异硫氰基苯基)硫脲 | CAS号 | 711019-86-2 |
|---|---|---|---|
| 价格 | 纯度 | 98.0% | |
| 备货期 | 10天 | 库存 | 现货 |
| 产品详情（用途，包装等）
用途： MRS2578 is a potent P2Y6 receptor antagonist with IC50 of 37 nM, exhibits insignificant activity at P2Y1, P2Y2, P2Y4,and P2Y11 receptors.IC50 value: 37 nM [1]Target: P2Y6 receptorin vitro: MRS2578 selectively blocks P2Y6 receptor activity versus activity at P2Y1, P2Y2, P2Y4 or P2Y11 receptors. MRS2578 (1 μM) completely blocks the protection by UDP undergoing TNFalpha-induced apoptosis in 1321N1 astrocytoma cells [1]. MRS 2578 inhibits basal NF-κB activity in time and dose dependent manner in HMEC-1 cells transfected with 0.25 μg NF-κB promoter reporter. MRS 2578 (10 μM) completely abolishes TNF-α induced NF-κB reporter activity in HMEC-1 cells. MRS 2578 (10 μM) significant reduces TNF-α–induced proinflammatory gene expression in HMEC-1 cells [2]. MRS2578-treated mice shows reduced bronchial hyperresponsiveness toward methacholine in OVA-sensitized mice. MRS2578 completely blocks UDP-induced the release of IL-6, KC, and IL-8 in lung epithelial cells [3]. in vivo: MRS 2578 (10 μM) attenuates Keratinocyte-derived chemokine serum protein levels in LPS-induced vascular inflammation in C57BL/6 mice [2]. MRS2578 (10 μM, intratracheally) reduces BALF eosinophilia and the levels of IL-5 and IL-13 in the BALF in OVA-sensitized mice and leads to a markedly attenuated change in methacholine responsiveness after OVA challenge. MRS2578 (10 μM, intratracheally) inhibits house dust mite–induced allergic airway inflammation in OVA-sensitized mice. MRS2578 (10 μM, intratracheally) reduces of IL-6 and KC levels in BALF in OVA-sensitized mice [4]. 物理化学性质： CAS号：711019-86-2 常用中文名：N,N''-1,4-丁烷二基双[N'-(3-异异硫氰基苯基)硫脲 常用英文名：MRS 2578 分子式：C20H20N6S4 分子量：472.673 密度：1.3±0.1 g/cm3 沸点：652.7±65.0 °C at 760 mmHg 熔点：N/A 闪点：348.5±34.3 °C 储存条件：2-8°C |
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- 上海阿拉丁生化科技股份有限公司
- 上海市 上海市 浦东新区
- 产品名：MRS 2578
- 价格： ￥468.9/10mg ￥1381.9/50mg ￥需询单/1g ￥需询单/1g
- 纯度：98.0%
- 备货期：1天
- 联系人：阿拉丁
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- 上海化源世纪贸易有限公司
- 上海市 上海市 普陀区
- 产品名：1,1'-(丁烷-1,4-二基)双(3-(3-异硫氰酸苯)硫脲)
- 价格：
- 纯度：98.0%
- 备货期：10天
- 联系人：徐经理
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N,N''-1,4-丁烷二基双[N'-(3-异异硫氰基苯基)硫脲生产厂家
参考价格：$77/10mM*1mLinDMSO