沃诺拉赞
更新时间：2024-07-15 12:37:18
采购访问：22次
| 常用名 | 沃诺拉赞 | CAS号 | 881681-00-1 |
|---|---|---|---|
| 价格 | 纯度 | 98.0% | |
| 备货期 | 10天 | 库存 | 现货 |
| 产品详情（用途，包装等）
用途： TAK-438 (free base) is a novel P-CAB (potassium-competitive acid blocker) that reversibly inhibits H+/K+ ATPase with IC50 of 19 nM (pH 6.5), controls gastric acid secretion.IC50 value: 19 nM [1]Target: H+/K+ ATPasein vitro: TAK-438 is a pyrrole derivative with a chemical structure that is completely different from the P-CABs developed to date. TAK-438 inhibits gastric H+/K+ ATPase activity in a concentration-dependent manner. Under neutral conditions (pH 7.5), the inhibitory activity of TAK-438 is almost the same as that under weakly acidic conditions (pH 6.5). TAK-438 does not inhibit Na+/K+ ATPase activity even at concentration 500 times higher than their IC50 values against gastric H+/K+ ATPase activity. TAK-438 inhibits gastric H+/K+ ATPase in a K+ competitive manner with Ki of 3 nM [2]. in vivo: TAK-438 inhibits basal gastric acid secretion in a dose-dependent manner, and the ID50 value is 1.26 mg/kg. Intravenous administration of TAK-438 dose-dependently increases the pH of the gastric perfusate, and the increase in pH is sustained for 5 h after administration. At the 1 mg/kg dose, the pH plateaues 90 min after administration, and the highest pH value reached is 5.9 [2]. In addition, TAK-438 shows a potent and longer-lasting inhibitory effect on the histamine-stimulated gastric acid secretion in rats and dogs. TAK-438 shows significant antisecretory activity through high accumulation and slow clearance from the gastric tissue. TAK-438 is unaffected by the gastric secretory state, unlike PPIs [3]. 物理化学性质： CAS号：881681-00-1 常用中文名：沃诺拉赞 常用英文名：Vonoprazan 分子式：C17H16FN3O2S 分子量：345.391 密度：1.3±0.1 g/cm3 沸点：530.3±60.0 °C at 760 mmHg 熔点：N/A 闪点：274.5±32.9 °C |
上海念兴实业有限公司
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- 山东铂源药业有限公司
- 山东省 济南市 历城区
- 产品名：沃诺拉赞/伏诺拉生
- 价格： ￥需询单/1kg
- 纯度：99.0%
- 备货期：需询单
- 联系人：滕经理
- 上海阿拉丁生化科技股份有限公司
- 上海市 上海市 浦东新区
- 产品名：沃诺拉赞
- 价格： ￥1649.9/1g ￥399.9/100mg ￥619.9/250mg ￥239.9/50mg
- 纯度：98.0%
- 备货期：1天
- 联系人：阿拉丁
- 上海化源世纪贸易有限公司
- 上海市 上海市 普陀区
- 产品名：沃诺拉赞
- 价格：
- 纯度：98.0%
- 备货期：10天
- 联系人：徐经理
- 上海阿摩尔生物科技有限公司
- 上海市 上海市 奉贤区
- 产品名：沃诺拉赞
- 价格： ￥需询单/100g ￥需询单/100mg ￥需询单/1g ￥需询单/250mg
- 纯度：98.0%
- 备货期：需询单
- 联系人：王汐瑶
- 上海吉至生化科技有限公司
- 上海市 上海市 奉贤区
- 产品名：沃诺拉赞
- 价格： ￥506.0/50mg ￥356.0/10mg ￥676.0/100mg
- 纯度：98.0%
- 备货期：2天
- 联系人：刘佳
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参考价格：$66/10mM*1mLinDMSO