盐酸依福地平一乙醇盐
更新时间：2025-09-11 13:52:18
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| 常用名 | 盐酸依福地平 | CAS号 | 111011-76-8 |
|---|---|---|---|
| 价格 | 纯度 | 99.0% | |
| 备货期 | 10天 | 库存 | 现货 |
| 产品详情（用途，包装等）
用途： Efonidipine(NZ-105) Hcl monoethanolate is a dual T-type and L-type calcium channel blocker (CCB).IC50 value: Target: calcium channel blockerin vitro: Efonidipine and nifedipine, but not other examined CCBs, also increased the N(6), 2'-O-dibutyryladenosine 3',5'-cyclic monophosphate (dbcAMP)-induced StAR mRNA, which reflects the action of adrenocorticotropic hormone, and efonidipine and R(-)-efonidipine enhanced the dbcAMP-induced DHEA-S production in NCI-H295R adrenocortical carcinoma cells [1]. I(Ca(T)) was blocked mainly by a tonic manner by nifedipine, by a use-dependent manner by mibefradil, and by a combination of both manners by efonidipine. IC50s of these Ca2+ channel antagonists to I(Ca(T)) and L-type Ca2+ channel current (I(Ca(L))) were 1.2 micromol/l and 0.14 nmol/l for nifedipine; 0.87 and 1.4 micromol/l for mibefradil, and 0.35 micromol/l and 1.8 nmol/l for efonidipine, respectively [4].in vivo: Twenty hypertensive patients on chronic hemodialysis were given efonidipine 20-60 mg twice daily and amlodipine 2.5-7.5 mg once daily for 12 weeks each in a random crossover manner. The average blood pressure was comparable between the efonidipine and amlodipine periods (151 + or - 15/77 + or - 8 versus 153 + or - 15/76 + or - 8 mmHg). The pulse rate did not change significantly during the administration periods [2]. In the UM-X7.1 group, EFO treatment significantly attenuated the decrease of LVEF without affecting blood pressure compared with the vehicle group. EFO treatment decreased heart rate (by approximately 10%) in both groups [3]. 物理化学性质： CAS号：111011-76-8 常用中文名：盐酸依福地平 常用英文名：Efonidipine 分子式：C36H45ClN3O8P 分子量：631.655 密度：1.3±0.1 g/cm3 沸点：746.9±60.0 °C at 760 mmHg 熔点：151° (dec) 闪点：405.5±32.9 °C 储存条件：Desiccate at +4°C |
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- 上海市 上海市 普陀区
- 产品名：盐酸依福地平一乙醇盐
- 价格：
- 纯度：99.0%
- 备货期：10天
- 联系人：徐经理
- 上海源溪生物科技有限公司
- 上海市 上海市 浦东新区
- 产品名：Efonidipine (hydrochloride monoethanolate)
- 价格： ￥需询单/1g
- 纯度：98.9%
- 备货期：1天
- 联系人：赖经理
- 上海阿拉丁生化科技股份有限公司
- 上海市 上海市 浦东新区
- 产品名：盐酸依非替尼单乙醇酸盐
- 价格： ￥144.9/1mg ￥1926.9/25mg ￥514.9/5mg ￥720.9/1ml
- 纯度：98.0%
- 备货期：1天
- 联系人：阿拉丁
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参考价格：$106/10mM*1mLinDMSO