盐酸依福地平

更新时间：2024-01-13 17:50:24

盐酸依福地平结构式	常用名	盐酸依福地平	英文名	Efonidipine
	CAS号	111011-76-8	分子量	631.655
	密度	1.3±0.1 g/cm3	沸点	746.9±60.0 °C at 760 mmHg
	分子式	C₃₆H₄₅ClN₃O₈P	熔点	151° (dec)
	MSDS	N/A	闪点	405.5±32.9 °C

盐酸依福地平用途

Efonidipine(NZ-105)盐酸盐是T型和L型钙离子通道双重阻断剂。

中文名	盐酸依福地平
英文名	Efonidipine hydrochloride ethanolate
英文别名	更多

描述	Efonidipine(NZ-105)盐酸盐是T型和L型钙离子通道双重阻断剂。
相关类别	信号通路 >> 跨膜转运 >> 钙通道研究领域 >> 心血管疾病
参考文献	[1]. Ikeda K, et al. Efonidipine, a Ca(2+)-channel blocker, enhances the production of dehydroepiandrosterone sulfate in NCI-H295R human adrenocortical carcinoma cells. Tohoku J Exp Med. 2011;224(4):263-71. [2]. Nakano N, et al. Effects of efonidipine, an L- and T-type calcium channel blocker, on the renin-angiotensin-aldosterone system in chronic hemodialysis patients. Int Heart J. 2010 May;51(3):188-92. [3]. Suzuki S, et al. Beneficial effects of the dual L- and T-type Ca2+ channel blocker efonidipine on cardiomyopathic hamsters. Circ J. 2007 Dec;71(12):1970-6. [4]. Lee TS, et al. Actions of mibefradil, efonidipine and nifedipine block of recombinant T- and L-type Ca channels with distinct inhibitory mechanisms. Pharmacology. 2006;78(1):11-20.

描述

Efonidipine(NZ-105)盐酸盐是T型和L型钙离子通道双重阻断剂。

相关类别

信号通路 >> 跨膜转运 >> 钙通道

研究领域 >> 心血管疾病

参考文献

[1]. Ikeda K, et al. Efonidipine, a Ca(2+)-channel blocker, enhances the production of dehydroepiandrosterone sulfate in NCI-H295R human adrenocortical carcinoma cells. Tohoku J Exp Med. 2011;224(4):263-71.

[2]. Nakano N, et al. Effects of efonidipine, an L- and T-type calcium channel blocker, on the renin-angiotensin-aldosterone system in chronic hemodialysis patients. Int Heart J. 2010 May;51(3):188-92.

[3]. Suzuki S, et al. Beneficial effects of the dual L- and T-type Ca2+ channel blocker efonidipine on cardiomyopathic hamsters. Circ J. 2007 Dec;71(12):1970-6.

[4]. Lee TS, et al. Actions of mibefradil, efonidipine and nifedipine block of recombinant T- and L-type Ca channels with distinct inhibitory mechanisms. Pharmacology. 2006;78(1):11-20.

密度	1.3±0.1 g/cm3
沸点	746.9±60.0 °C at 760 mmHg
熔点	151° (dec)
分子式	C₃₆H₄₅ClN₃O₈P
分子量	631.655
闪点	405.5±32.9 °C
精确质量	631.244751
PSA	152.96000
LogP	6.99
蒸汽压	0.0±2.5 mmHg at 25°C
折射率	1.625
储存条件	Desiccate at +4°C

盐酸依福地平毒性英文版

2-(N-Benzylanilino)ethyl (±)-1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-5-phosphononicotinate Cyclic 2,2-Dimethyltrimethylene Ester

2-[Benzyl(phenyl)amino]ethyl 5-(5,5-dimethyl-2-oxido-1,3,2-dioxaphosphinan-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate

3-Pyridinecarboxylic acid, 5-(5,5-dimethyl-2-oxido-1,3,2-dioxaphosphorinan-2-yl)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-[phenyl(phenylmethyl)amino]ethyl ester

5-(5,5-Dimethyl-1,3,2-dioxaphosphorinan-2-yl)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3-pyridinecarboxylic Acid 2-[Phenyl(phenylmethyl)amino]ethyl Ester P-Oxide

Landel

(±)-Efonidipine

Efonidipine

2-[Benzyl(phenyl)amino]ethyl 5-(5,5-dimethyl-2-oxido-1,3,2-dioxaphosphinan-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3-pyridinecarboxylate

Efonidipine (hydrochloride monoethanolate)