Mirin
更新时间：2025-08-30 11:05:51
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| 常用名 | (5Z)-2-氨基-5-[(4-羟基苯基)亚甲基]-4(5H)-噻唑酮 | CAS号 | 1198097-97-0 |
|---|---|---|---|
| 价格 | 纯度 | 99.0% | |
| 备货期 | 10天 | 库存 | 现货 |
| 产品详情（用途，包装等）
用途： Mirin is a small-molecule inhibitor of MRN (Mre11, Rad50, and Nbs1) complex.Target: in vitro: Mirin was shown to block Mre11 exonuclease activity and MRN-dependent ATM activation, and to inhibit the ionizing radiation-induced G2/M checkpoint and homologous recombination in mammalian cells. Mirin inhibition of ATM activation is independent of Mre11 nuclease inhibition since the M(HN)RN and M(HL/DV)RN mutant complexes are inhibited equivalently to the wild-type enzyme despite the fact that they are nuclease-deficient. The effects of Mirin have been ascribed to its effects on Mre11 nuclease activity, but as we show here, Mirin is inhibitory of MRN function independent of the nuclease activity of the complex. [2] Addition of the Mre11 inhibitor Mirin to egg extracts and mammalian cells reduces RCC1 association with mitotic chromosomes. HeLa cells expressing Histone H2B-EYFP were treated with Mirin (25 or 50 μM), and mitotic progression was immediately monitored using live cell imaging. Although Mirin-treated cells were able to congress chromosomes to the metaphase plate with similar kinetics as untreated cells, a significant fraction of Mirin-treated cells paused for extended periods of time in a metaphase-like stage without anaphase onset . [1] 物理化学性质： CAS号：1198097-97-0 常用中文名：(5Z)-2-氨基-5-[(4-羟基苯基)亚甲基]-4(5H)-噻唑酮 常用英文名：Mirin 分子式：C10H8N2O2S 分子量：220.248 密度：1.5±0.1 g/cm3 沸点：441.6±55.0 °C at 760 mmHg 熔点：298 °C 闪点：220.8±31.5 °C 储存条件：0-10°C;存放于惰性气体之中;避免空气,加热 |
上海化源世纪贸易有限公司
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- 上海阿拉丁生化科技股份有限公司
- 上海市 上海市 浦东新区
- 产品名：Mirin
- 价格： ￥328.9/5mg ￥2307.9/100mg ￥411.9/10mg ￥822.9/25mg
- 纯度：99.0%
- 备货期：1天
- 联系人：阿拉丁
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(5Z)-2-氨基-5-[(4-羟基苯基)亚甲基]-4(5H)-噻唑酮生产厂家
参考价格：$66/10mM*1mLinDMSO