(5Z)-2-氨基-5-[(4-羟基苯基)亚甲基]-4(5H)-噻唑酮

• 常用名: (5Z)-2-氨基-5-[(4-羟基苯基)亚甲基]-4(5H)-噻唑酮
• 英文名: Mirin
• CAS号: 1198097-97-0
• 分子量: 220.248
• 密度: 1.5±0.1 g/cm3
• 沸点: 441.6±55.0 °C at 760 mmHg
• 分子式: C₁₀H₈N₂O₂S
• 熔点: 298 °C
• 闪点: 220.8±31.5 °C

用途

Mirin是小分子MRN(Mre11,Rad50,和Nbs1)复合物的抑制剂。

名称

• 中文名: (5Z)-2-氨基-5-[(4-羟基苯基)亚甲基]-4(5H)-噻唑酮
• 英文名: (Z)-5-(4-hydroxybenzylidene)-2-imino-4-oxo-thiazolidine

生物活性

• 描述: Mirin是小分子MRN(Mre11,Rad50,和Nbs1)复合物的抑制剂。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 癌症
• 参考文献:

  [1]. Rozier L, et al. The MRN-CtIP pathway is required for metaphase chromosome alignment. Mol Cell. 2013 Mar 28;49(6):1097-107.

  [2]. Lee JH, et al. Ataxia telangiectasia-mutated (ATM) kinase activity is regulated by ATP-driven conformational changes in the Mre11/Rad50/Nbs1 (MRN) complex. J Biol Chem. 2013 May 3;288(18):12840-51.

  [3]. Garner KM, et al. Corrected structure of Mirin, a small-molecule inhibitor of the Mre11-Rad50-Nbs1 complex. Nat Chem Biol. 2009 Mar;5(3):129-30.

物理化学性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 441.6±55.0 °C at 760 mmHg
• 熔点: 298 °C
• 分子式: C₁₀H₈N₂O₂S
• 分子量: 220.248
• 闪点: 220.8±31.5 °C
• 精确质量: 220.030655
• PSA: 98.48000
• LogP: 1.36
• InChIKey: YBHQCJILTOVLHD-YVMONPNESA-N
• SMILES: N=C1NC(=O)C(=Cc2ccc(O)cc2)S1
• 外观性状: 固体;White to Yellow powder to crystal
• 蒸汽压: 0.0±1.1 mmHg at 25°C
• 折射率: 1.718
• 储存条件: 0-10°C;存放于惰性气体之中;避免空气,加热

靶点实验

查看更多实验

实验名称：Discovery of Small Molecules to Inhibit Human Cytomegalovirus Nuclear Egress 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：HCMV UL50 External Id：HMS1262

实验名称：A screen for small molecules that modulate mitochondrial supercomplex formation 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：N/A External Id：HMS1482

实验名称：Cell-based high throughput primary assay to identify activators of GPR151 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=G-protein coupled receptor 151; AltName: Full=G-protein coupled receptor PGR7; AltName: Full=GPCR-2037; AltName: Full=Galanin receptor 4; AltName: Full=Galanin-receptor-like protein; Short=GalRL External Id：GPR151_PHUNTER_AG_LUMI_1536_1X%ACT

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify inhibitors of... 来源：The Scripps Research Institute Molecular Screening Center External Id：MITF_INH_Alpha_1536_1X%INH PRUN

实验名称：Stabilization of p53 in human papillomavirus-positive cells 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：Cellular tumor antigen p53 External Id：HMS1485

实验名称：Discovering small molecule activators of G protein-gated inwardly-rectifying potassiu... 来源：15621 靶标：G protein-activated inward rectifier potassium channel 2 External Id：VANDERBILT_HTS_GIRK2_MPD

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英文别名

• 5-(4-Hydroxy-benzylidene)-2-imino-thiazolidin-4-one
• (5Z)-2-Amino-5-(4-hydroxybenzylidene)-1,3-thiazol-4(5H)-one
• Lu AA 47070