MGCD-265
更新时间：2025-08-27 07:44:27
采购访问：14次
| 常用名 | N-(3-氟-4-(2-(1-甲基-1H-咪唑-4-基)噻吩并[3,2-B]吡啶-7-氧基)苯基氨基硫代甲酰基)-2-苯乙酰胺 | CAS号 | 875337-44-3 |
|---|---|---|---|
| 价格 | 纯度 | 98.0% | |
| 备货期 | 10天 | 库存 | 现货 |
| 产品详情（用途，包装等）
用途： MGCD-265-analog (structurally related to MGCD-265) is an orally bioavailable multitargeted tyrosine kinase inhibitor with potential antineoplastic activity with IC50 of 29 nM and 10 nM for c-Met and VEGFR2, respectively.IC50 value:10 nM (VEGFR2), 29 nM(c-Met) [1]Target:VEGFR, c-Metin vivo: MGCD-265-analog has a reasonable half-life, 1.2 h in rats and 5.8 h in dogs, and has an acceptable clearance, 0.33 L/(kg h) in rats and 1.1 L/(kg h) in dogs. The steady state volume of distribution was low in rats (0.25 L/kg) and reasonable in dogs (1.5 L/kg), while the oral bio-availability was determined to be 12% and 42% in rats and dogs, respectively. GCD-265-analog performed well in vivo against a panel of different human tumor types, particularly those that are driven by or overexpress c-Met (MNNGHOS and MKN45). Tumor growth inhibition at a dose of 20 mg/kg po once daily ranged from 41% to 94%. MGCD-265-analog was found to show spill-over inhibition of a number of kinases in addition to the intended c-Met/VEGFR2 activity. MGCD-265-analog has significant antitumor activity in vivo.[1] 物理化学性质： CAS号：875337-44-3 常用中文名：N-(3-氟-4-(2-(1-甲基-1H-咪唑-4-基)噻吩并[3,2-B]吡啶-7-氧基)苯基氨基硫代甲酰基)-2-苯乙酰胺 常用英文名：MGCD-265 分子式：C26H20FN5O2S2 分子量：517.598 密度：1.4±0.1 g/cm3 沸点：195.7ºC at 760 mmHg 熔点：N/A 闪点：72.1ºC 储存条件：-20℃ |
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- 产品名：MGCD-265
- 价格： ￥799.9/10mg ￥599.9/5mg ￥3599.9/100mg ￥2199.9/50mg
- 纯度：98.0%
- 备货期：1天
- 联系人：阿拉丁
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N-(3-氟-4-(2-(1-甲基-1H-咪唑-4-基)噻吩并[3,2-B]吡啶-7-氧基)苯基氨基硫代甲酰基)-2-苯乙酰胺生产厂家
参考价格：$164/10mM*1mLinDMSO