ASIC1a inhibitor 5b
更新时间：2024-07-17 16:20:39
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| 常用名 | ASIC1a inhibitor 5b | CAS号 | 1787243-08-6 |
|---|---|---|---|
| 价格 | ￥需询单/100mg ￥需询单/250mg ￥需询单/1g | 纯度 | 98.0% |
| 备货期 | 10天 | 库存 | 现货 |
| 产品详情（用途，包装等）
用途： ASIC1a inhibitor 5b is a highly selective and potent ASIC1a inhibitor, inhibits proton-evoked ASIC1a currents with an apparent IC50 of 27 nM at pH 6.7.ASIC1a inhibitor 5b can potently and selectively inhibit acid-induced activation of ASIC1a-containing channels, including both ASIC1a homotrimers and ASIC1a-ASIC2 heterotrimers, in a pH-dependent manner.ASIC1a inhibitor 5b binds to the acidic pocket of ASIC1a, exhibits a dramatic leftward shift under pH 6.7 activation of ASIC1a as compared to pH 6.0.ASIC1a inhibitor 5b protected neurons from ASIC1a-dependent cell death and is blood-brain barrier permeable.ASIC1a inhibitor 5b (5 mg/kg) attenuated neurological impairment and alleviated infarct volume in mouse MCAO model of ischemic stroke. 物理化学性质： CAS号：1787243-08-6 常用中文名：ASIC1a inhibitor 5b 常用英文名：ASIC1a inhibitor 5b 分子式：C23H29Cl3N4O2 分子量：499.861 密度：N/A 沸点：N/A 熔点：N/A 闪点：N/A |
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