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乙酸香叶酯

乙酸香叶酯用途

Geranyl acetate 是一种由香叶醇衍生而来的无环单萜烯酯,因为具有香味而被广泛用于化妆品行业。Geranyl acetate 可诱导细胞凋亡 (apoptosis)。

乙酸香叶酯名称

[ CAS 号 ]:
105-87-3

[ 中文名 ]:
乙酸香叶酯

[ 英文名 ]:
acetic acid geranyl ester

[中文别名 ]:

[英文别名 ]:

Geranylacetat
Geranyl acetate
(E)-3,7-Dimethyl-2,6-octadien-1-yl acetate
2,6-Octadien-1-ol, 3,7-dimethyl-, acetate, (2E)-
geranylacetate
Geranyl ethanonte
trans-3,7-Dimethyl-2,6-octadien-1-ol, acetate
Acetic acid, geranyl ester
MFCD00015037
trans-3,7-Dimethyl-2,6-octadien-1-ol acetate

乙酸香叶酯生物活性

[ 描述 ]:

Geranyl acetate 是一种由香叶醇衍生而来的无环单萜烯酯,因为具有香味而被广泛用于化妆品行业。Geranyl acetate 可诱导细胞凋亡 (apoptosis)。

[ 相关类别 ]:

信号通路 >> 细胞凋亡 >> 细胞凋亡

研究领域 >> 癌症

[体外研究]

香叶基乙酸酯对colo-205癌细胞系具有显着的抗癌活性,IC50值为30μM[2]。香叶基乙酸酯诱导colo-205细胞凋亡,这种凋亡与Bax的上调和Bcl-2表达的下调有关[2]。

[参考文献]

[1]. Wu T, et al. Engineering Saccharomyces cerevisiae for the production of the valuable monoterpene ester geranyl acetate. Microb Cell Fact. 2018 Jun 5;17(1):85.

[2]. Qi F, et al. Geraniol and geranyl acetate induce potent anticancer effects in colon cancer Colo-205 cells by inducing apoptosis, DNA damage and cell cycle arrest. J BUON. 2018 Mar-Apr;23(2):346-352.

乙酸香叶酯物理化学性质

[ 密度 ]:
0.9±0.1 g/cm3

[ 沸点 ]:
247.5±0.0 °C at 760 mmHg

[ 熔点 ]:
< 25ºC

[ 分子式 ]:
C₁₂H₂₀O₂

[ 分子量 ]:
196.286

[ 闪点 ]:
98.9±0.0 °C

[ 精确质量 ]:
196.146332

[ PSA ]:
26.30000

[ LogP ]:
4.10

[ 外观性状 ]:
无色至淡黄色液体

[ 蒸汽密度 ]:
6.8 (vs air)

[ 蒸汽压 ]:
0.0±0.5 mmHg at 25°C

[ 折射率 ]:
1.458

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
<0.1 g/100 mL at 20 ºC

乙酸香叶酯MSDS

乙酸香叶酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RG5920000

CHEMICAL NAME :: 2,6-Octadien-1-ol, 3,7-dimethyl-, acetate, (E)-

CAS REGISTRY NUMBER :: 105-87-3

BEILSTEIN REFERENCE NO. :: 1722815

LAST UPDATED :: 199701

DATA ITEMS CITED :: 19

MOLECULAR FORMULA :: C12-H20-O2

MOLECULAR WEIGHT :: 196.32

WISWESSER LINE NOTATION :: 1Y&U3YU2OV1 -T

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Human - man

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - guinea pig

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6330 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - coma

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 8 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 260 gm/kg/13W-I

TOXIC EFFECTS :: Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 28 gm/kg/14D-I

TOXIC EFFECTS :: Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 130 gm/kg/13W-I

TOXIC EFFECTS :: Liver - other changes Related to Chronic Data - death

TYPE OF TEST :: Unscheduled DNA synthesis

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 70 mg/L

REFERENCE :: EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 10(Suppl 10),1,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83198 No. of Facilities: 53 (estimated) No. of Industries: 3 No. of Occupations: 35 No. of Employees: 7388 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83198 No. of Facilities: 3954 (estimated) No. of Industries: 19 No. of Occupations: 25 No. of Employees: 48026 (estimated) No. of Female Employees: 33271 (estimated)

乙酸香叶酯安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
RG5920000

乙酸香叶酯合成路线

乙酸香叶酯上下游产品

乙酸香叶酯上游产品

乙酸香叶酯下游产品

乙酸香叶酯制备

1.由香叶醇乙酰化得到，或者从含有乙酸香叶醇的植物精油中分馏得到。

乙酸香叶酯文献

Identification of olfactory receptor neurons in Uraba lugens (Lepidoptera: Nolidae) and its implications for host range.

J. Insect Physiol. 78 , 33-46, (2015)

Phytophagous insects detect volatile compounds produced by host and non-host plants, using species-specific sets of olfactory receptor neurons (ORNs). To investigate the relationship between the range...

Bio-degradation of acetates of geraniol, nerol & citronellol by P. incognita: isolation & identification of metabolites.

Indian J. Biochem. Biophys. 20(3) , 136-40, (1983)

Mosquito odorant receptor for DEET and methyl jasmonate.

Proc. Natl. Acad. Sci. U. S. A. 111(46) , 16592-7, (2014)

Insect repellents are important prophylactic tools for travelers and populations living in endemic areas of malaria, dengue, encephalitis, and other vector-borne diseases. DEET (N,N-diethyl-3-methylbe...

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