<生产厂家价格>

Tyrphostin AG 1112

Tyrphostin AG 1112用途

Tyrphostin AG1112是CK II的有效抑制剂。Tyrphostin AG1112抑制p210bcr-abl酪氨酸激酶,在p210bcr-abl、EGFR和PDGFR细胞中的IC50值分别为2、15、20μM[1][2]。

Tyrphostin AG 1112名称

[ CAS 号 ]:
153150-84-6

[ 英文名 ]:
Tyrphostin AG 1112

Tyrphostin AG 1112生物活性

[ 描述 ]:

Tyrphostin AG1112是CK II的有效抑制剂。Tyrphostin AG1112抑制p210bcr-abl酪氨酸激酶,在p210bcr-abl、EGFR和PDGFR细胞中的IC50值分别为2、15、20μM[1][2]。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 代谢酶/蛋白酶 >> 酪氨酸酶

信号通路 >> 细胞周期/DNA损伤 >> 酪蛋白激酶

信号通路 >> 干细胞及 Wnt 通路 >> 酪蛋白激酶

[体外研究]

Tyrphostin AG1112(0-100μM)剂量依赖性诱导分化,也诱导特异性生长停滞[1]。

[参考文献]

[1]. T B Kang, et al. Action of 3 tyrphostin derivatives on casein kinase II from rat liver. Zhongguo Yao Li Xue Bao. 1997 Jan;18(1):56-8.

[2]. M Anafi, et al. Tyrphostin-induced inhibition of p210bcr-abl tyrosine kinase activity induces K562 to differentiate. Blood. 1993 Dec 15;82(12):3524-9.

Tyrphostin AG 1112物理化学性质

[ 分子式 ]:
C₁₅H₁₀N₆

[ 分子量 ]:
274.28

[ 外观性状 ]:
solid

[ 储存条件 ]:
−20°C

Tyrphostin AG 1112安全信息

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
36/37/38-40

[ 安全声明 (欧洲) ]:
26-36/37

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
1

Tyrphostin AG 1112文献

Protein kinase inhibitors as a therapeutic modality.

Acc. Chem. Res. 36(6) , 462-9, (2003)

Most of the signal transduction pathways are mediated by protein kinases regulating every aspect of cell function. Mutations which deregulate their expression or their function or both result in cance...

Tyrphostin-induced inhibition of p210bcr-abl tyrosine kinase activity induces K562 to differentiate.

Blood 82(12) , 3524-9, (1993)

We report on the potency of two Tyrphostin tyrosine kinase blockers, AG 1112 and AG 568, to inhibit p210bcr-abl tyrosine kinase activity in K562 cells, concomitant with the induction of erythroid diff...

更多文献