Virginiamycin S1

Virginiamycin S1用途

Virginiamycin S1 是环状十六肽抗生素,由弗氏链霉菌 (Streptomyces virginiae) 产生, 在氨酰基-tRNA 结合和肽键形成的水平上抑制细菌蛋白质合成,对多种革兰氏阳性菌显示出强大的杀菌活性。Virginiamycin S1 属于链阳性菌属家族中的 B 型化合物,与链阳性菌属家族中的 A 型化合物Virginiamycin M1 协同治疗多药耐药性细菌感染更有效。

Virginiamycin S1名称

[ CAS 号 ]:
23152-29-6

[ 英文名 ]:
Virginiamycin S1

[英文别名 ]:

avilamycin

Virginiamycin S1生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 抗感染 >> 细菌

[参考文献]

[1]. Ningsih F, et al. VisG is essential for biosynthesis of virginiamycin S, a streptogramin type B antibiotic, as a provider of the nonproteinogenic amino acid phenylglycine. Microbiology. 2011 Nov;157(Pt 11):3213-20.

[2]. Ge B, et al. Purification and characterization of virginiamycin M1 reductase from Streptomyces virginiae. Sci Rep. 2017 Sep 8;7(1):11017.

Virginiamycin S1物理化学性质

[ 分子式 ]:
C₄₃H₄₉N₇O₁₀

[ 分子量 ]:
823.89000

[ 精确质量 ]:
823.35400

[ PSA ]:
224.72000

[ LogP ]:
2.06620

[ 蒸汽压 ]:
0mmHg at 25°C

[ 储存条件 ]:
-20°C，密闭，干燥

Virginiamycin S1安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

Virginiamycin S1文献

Purification and characterization of virginiamycin M1 reductase from Streptomyces virginiae.

Antimicrob. Agents Chemother. 42 , 2985-2988, (1998)

Virginiamycin M1 (VM1), produced by Streptomyces virginiae, is a polyunsaturated macrocyclic lactone antibiotic belonging to the virginiamycin A group. S. virginiae possesses an activity which stereos...

VisG is eβential for biosynthesis of virginiamycin S, a streptogramin type B antibiotic, as a provider of the nonproteinogenic amino acid phenylglycine Fitria Ningsih, Shigeru Kitani, et al.

Microbiology 167 , 3213 - 3220, (2011)

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