<生产厂家价格>

氨甲叶酸杂质C

氨甲叶酸杂质C用途

Methopterin 抑制破骨细胞增殖。Methopterin 抑制破骨细胞的活化和骨吸收功能,诱导破骨细胞凋亡 (apoptosis)。

氨甲叶酸杂质C名称

[ CAS 号 ]:
2410-93-7

[ 中文名 ]:
氨甲叶酸杂质C

[ 英文名 ]:
2-[[4-[(2-Amino-4-Oxo-1H-Pteridin-6-Yl)Methyl-Methylamino]Benzoyl]Amino]Pentanedioic Acid

[中文别名 ]:

[英文别名 ]:

N(10)-methylfolate
N-(10-methyl-pteroyl)-L-glutamic acid
Methotrexate impurity C
10-Methylpteroylglutamic acid
N10-methylfolic acid
N10-MethylpteroylglutaMic Acid
1-methylfolic acid
N-(10-Methyl-pteroyl)-L-glutaminsaeure
10-methylpteroylglutamlic acid

氨甲叶酸杂质C生物活性

[ 描述 ]:

Methopterin 抑制破骨细胞增殖。Methopterin 抑制破骨细胞的活化和骨吸收功能,诱导破骨细胞凋亡 (apoptosis)。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 炎症/免疫

[参考文献]

[1]. Li P, et al. [Effects of methopterin on osteoclasts and study of its mechanism of action]. Yao Xue Xue Bao. 2008 Oct;43(10):1025-31.

氨甲叶酸杂质C物理化学性质

[ 密度 ]:
1.61g/cm3

[ 分子式 ]:
C₂₀H₂₁N₇O₆

[ 分子量 ]:
455.42400

[ 精确质量 ]:
455.15500

[ PSA ]:
204.75000

[ LogP ]:
1.36390

[ 折射率 ]:
1.732

氨甲叶酸杂质C毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MA0700000

CHEMICAL NAME :: Glutamic acid, N-(p-(((2-amino-4-hydroxy-6-pteridyl)methyl)methylami no)benzoyl)-

CAS REGISTRY NUMBER :: 2410-93-7

LAST UPDATED :: 199712

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C20-H21-N7-O6

MOLECULAR WEIGHT :: 455.48

WISWESSER LINE NOTATION :: T66 BN DN GN JNJ CZ EQ H1NVR D1Z&YVQ2VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CBCCT* "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. (National Academy of Science Library, 2101 Constitution Ave., NW, Washington, DC 20418) Volume(issue)/page/year: 7,688,1955

氨甲叶酸杂质C安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

氨甲叶酸杂质C合成路线

详细合成路线

氨甲叶酸杂质C上下游产品

氨甲叶酸杂质C上游产品

氨甲叶酸杂质C下游产品

氨甲叶酸杂质C文献

The methyl folate trap. A physiological response in man to prevent methyl group deficiency in kwashiorkor (methionine deficiency) and an explanation for folic-acid induced exacerbation of subacute combined degeneration in pernicious anaemia.

Lancet 2(8242) , 337-40, (1981)

It is suggested that in man the methyl folate trap is a normal physiological response to impending methyl group deficiency resulting from a very low supply of methionine. This decreases cellular S-ade...

Enhancement of recovery from psychiatric illness by methylfolate.

Lancet 336(8712) , 392-5, (1990)

41 (33%) of 123 patients with acute psychiatric disorders (DSM III diagnosis of major depression or schizophrenia) had borderline or definite folate deficiency (red-cell folate below 200 micrograms/l)...

Differential effects of stimulus termination on excitation and desensitization of folic acid receptors and guanylate cyclase in Dictyostelium discoideum.

Biochim. Biophys. Acta 930(1) , 1-9, (1987)

The response of guanylate cyclase to addition of extracellular stimuli is well documented. Here we report for the first time the response of guanylate cyclase to removal of stimuli. Three methods were...

更多文献