2410-93-7

• 常用中文名：氨甲叶酸杂质C
• 常用英文名：2-[[4-[(2-Amino-4-Oxo-1H-Pteridin-6-Yl)Methyl-Methylamino]Benzoyl]Amino]Pentanedioic Acid
• CAS号：2410-93-7
• 分子式：C₂₀H₂₁N₇O₆
• 分子量：455.42400
• 相关类别： 分析化学 标准品 药典标准品和杂志标准品
• 发布时间：2017-09-10 00:17:59
• 更新时间：2024-01-14 10:40:47
• Methopterin 抑制破骨细胞增殖。Methopterin 抑制破骨细胞的活化和骨吸收功能,诱导破骨细胞凋亡 (apoptosis)。

名称

• 中文名: 氨甲叶酸杂质C
• 英文名: L-Glutamic acid, N-[4-[[(2-amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]methylamino]benzoyl]-
• 中文别名: 2-[[4-[(2-氨基-4-氧代-1H-蝶啶-6-基)甲基-甲基氨基]苯甲酰基]氨基]戊烷二酸
• 英文别名: N-[p-[[(2-AMino-4-hydroxy-6-pteridinyl)Methyl]MethylaMino]benzoyl]glutaMic Acid; N(10)-methylfolate; N-(10-methyl-pteroyl)-L-glutamic acid; N-[4-[[(2-AMino-3,4-dihydro-4-oxo-6-pteridinyl)Methyl]MethylaMino]benzoyl]-L-glutaMic Acid; Methotrexate impurity C; 10-Methylpteroylglutamic acid; N10-methylfolic acid; N10-MethylpteroylglutaMic Acid; N-[p-[[(2-Amino-4-hydroxypteridin-6-yl)methyl]methylamino]benzoyl]-L-glutamic acid; N-[4-[[(2-Amino-4-hydroxy-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid; 1-methylfolic acid; N-(10-Methyl-pteroyl)-L-glutaminsaeure; 10-methylpteroylglutamlic acid; N-[4-[Methyl(2-amino-4-hydroxypteridine-6-ylmethyl)amino]benzoyl]glutamic acid; 2-[[4-[(2-Amino-4-Oxo-1H-Pteridin-6-Yl)Methyl-Methylamino]Benzoyl]Amino]Pentanedioic Acid

物化性质

• 密度: 1.61g/cm3
• 分子式: C₂₀H₂₁N₇O₆
• 分子量: 455.42400
• 精确质量: 455.15500
• PSA: 204.75000
• LogP: 1.36390
• 折射率: 1.732

生物活性

• 描述: Methopterin 抑制破骨细胞增殖。Methopterin 抑制破骨细胞的活化和骨吸收功能,诱导破骨细胞凋亡 (apoptosis)。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Li P, et al. [Effects of methopterin on osteoclasts and study of its mechanism of action]. Yao Xue Xue Bao. 2008 Oct;43(10):1025-31.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : MA0700000 CHEMICAL NAME : Glutamic acid, N-(p-(((2-amino-4-hydroxy-6-pteridyl)methyl)methylami no)benzoyl)- CAS REGISTRY NUMBER : 2410-93-7 LAST UPDATED : 199712 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C20-H21-N7-O6 MOLECULAR WEIGHT : 455.48 WISWESSER LINE NOTATION : T66 BN DN GN JNJ CZ EQ H1NVR D1Z&YVQ2VQ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Parenteral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1200 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CBCCT* "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. (National Academy of Science Library, 2101 Constitution Ave., NW, Washington, DC 20418) Volume(issue)/page/year: 7,688,1955

安全

• 危险品运输编码: NONH for all modes of transport

合成路线

59-05-2 ~80% 2410-93-7

文献：Charlton, Peter A.; Young, Douglas W. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , p. 1363 - 1370

4271-30-1 ~% 2410-93-7

文献：Journal of the American Chemical Society, , vol. 70, p. 1922,1925

38974-68-4 ~% 2410-93-7

文献：Journal of the American Chemical Society, , vol. 70, p. 1922,1925

52980-68-4 ~% 2410-93-7

文献：Journal of the American Chemical Society, , vol. 71, p. 1753,1757

1004-75-7 5221-17-0 52980-68-4 ~% 2410-93-7

文献：Journal of the American Chemical Society, , vol. 70, p. 1922,1925

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1004-75-7 5221-17-0
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