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甘氨脱氧胆酸

甘氨脱氧胆酸用途

诱发肝细胞凋亡，可能引起DNA分裂。

甘氨脱氧胆酸名称

[ CAS 号 ]:
360-65-6

[ 中文名 ]:
甘氨脱氧胆酸

[ 英文名 ]:
GLYCODEOXYCHOLIC ACID

[中文别名 ]:

[英文别名 ]:

Glycodeoxycholic acid monohydrate
Glycodeoxycholic acid
MFCD00150922

甘氨脱氧胆酸物理化学性质

[ 密度 ]:
1.162 g/cm3

[ 沸点 ]:
655.6ºC at 760 mmHg

[ 分子式 ]:
C₂₆H₄₅NO₆

[ 分子量 ]:
467.63900

[ 闪点 ]:
350.3ºC

[ 精确质量 ]:
467.32500

[ PSA ]:
116.09000

[ LogP ]:
3.92070

[ 外观性状 ]:
白色固体

[ 折射率 ]:
1.546

[ 储存条件 ]:
室温

甘氨脱氧胆酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MB9670000

CHEMICAL NAME :: Glycine, N-(3-alpha,12-alpha-dihydroxy-5-beta-cholan-24-yl)-

CAS REGISTRY NUMBER :: 360-65-6

LAST UPDATED :: 198803

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C26-H43-N-O4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 140 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 20,323,1970

甘氨脱氧胆酸安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
26

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
MB9670000

甘氨脱氧胆酸合成路线

详细合成路线

甘氨脱氧胆酸上下游产品

甘氨脱氧胆酸上游产品

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甘氨脱氧胆酸文献

Photophysical and photodynamical study of fluoroquinolone drug molecule in bile salt aggregates.

Photochem. Photobiol. 88 , 1248, (2012)

Photophysical properties of two widely used antibiotic fluoroquinolone drugs, namely Norfloxacin (NOR) and Ofloxacin (OFL) have been investigated in biomimicking environments formed by bile salts. Exp...

Quantification of cholesterol solubilized in bile salt micellar aqueous solutions using13C nuclear magnetic resonance

Anal. Biochem. 427(1) , 41-8, (2012)

In this work, we develop a methodology to quantitatively follow the solubilization of cholesterol on glycodeoxycholic acid (GDCA) micelles using 13C nuclear magnetic resonance (NMR). The amount of sol...

Effects of glutamine alone on the acute necrotizing pancreatitis in rats.

J. Surg. Res. 193(1) , 161-7, (2015)

The effects of the glutamine on the acute pancreatitis are controversial in the clinical and experimental studies. The aim of this study was to investigate the influence of glutamine alone on acute ne...

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