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佛波醇 12,13-二丁酸酯

佛波醇 12,13-二丁酸酯用途

Phorbol 12,13-dibutyrate (Phorbol dibutyrate) 是一种 PKC 激活剂和有效的皮肤肿瘤启动子。

佛波醇 12,13-二丁酸酯名称

[ CAS 号 ]:
37558-16-0

[ 中文名 ]:
佛波醇 12,13-二丁酸酯

[ 英文名 ]:
Phorbol-12

[英文别名 ]:

PDBU
PHORBOL 12,13-DIBUTYRATE,4BETA
MFCD00036783
Phorbol 12,13-dibutanoate
Phorbol 12,13-dibutyrate

佛波醇 12,13-二丁酸酯生物活性

[ 描述 ]:

Phorbol 12,13-dibutyrate (Phorbol dibutyrate) 是一种 PKC 激活剂和有效的皮肤肿瘤启动子。

[ 相关类别 ]:

信号通路 >> 表观遗传学 >> PKC

研究领域 >> 癌症

信号通路 >> TGF-beta/Smad 信号通路 >> PKC

[ 靶点 ]

PKC[1]

[体外研究]

佛波醇12,13-二丁酸酯(佛波醇二丁酸酯)(1毫米)激活PKC并抑制OK细胞中的Na/K-ATP酶转运活性[3]。

[参考文献]

[1]. Singh J, et al. Immunocytochemical evidence for PDBu-induced activation of RhoA/ROCK in human internal anal sphincter smooth muscle cells. Am J Physiol Gastrointest Liver Physiol. 2011 Aug;301(2):G317-25.

[2]. Szallasi Z, et al. Dissociation of phorbol esters leads to immediate redistribution to the cytosol of protein kinases C alpha and C delta in mouse keratinocytes. J Biol Chem. 1994 Nov 4;269(44):27159-62.

[3]. Middleton JP, et al. Heterogeneity of protein kinase C-mediated rapid regulation of Na/K-ATPase in kidney epithelial cells. J Biol Chem. 1993 Jul 25;268(21):15958-64.

佛波醇 12,13-二丁酸酯物理化学性质

[ 密度 ]:
1.27g/cm3

[ 沸点 ]:
623.4ºC at 760mmHg

[ 分子式 ]:
C₂₈H₄₀O₈

[ 分子量 ]:
504.61200

[ 闪点 ]:
199.3ºC

[ 精确质量 ]:
504.27200

[ PSA ]:
130.36000

[ LogP ]:
2.63210

[ 外观性状 ]:
powder | clear, light yellow, film

[ 折射率 ]:
1.574

[ 储存条件 ]:
−20°C

[ 水溶解性 ]:
H2O: 30 μM

佛波醇 12,13-二丁酸酯安全信息

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
2928

[ WGK德国 ]:
3

[ RTECS号 ]:
EK7767000

[ 包装等级 ]:
II

[ 危险类别 ]:
6.1(a)

佛波醇 12,13-二丁酸酯文献

A-kinase Anchoring Protein 79/150 Recruits Protein Kinase C to Phosphorylate Roundabout Receptors.

J. Biol. Chem. 290 , 14107-19, (2015)

Anchoring proteins direct protein kinases and phosphoprotein phosphatases toward selected substrates to control the efficacy, context, and duration of neuronal phosphorylation events. The A-kinase anc...

Charge density influences C1 domain ligand affinity and membrane interactions.

ChemBioChem. 15(8) , 1131-44, (2014)

The C1 domain, which represents the recognition motif on protein kinase C for the lipophilic second messenger diacylglycerol and its ultrapotent analogues, the phorbol esters, has emerged as a promisi...

Differential 12-O-Tetradecanoylphorbol-13-acetate-induced activation of rat mammary carcinoma susceptibility Fbxo10 variant promoters via a PKC-AP1 pathway.

Mol. Carcinog. 54(2) , 134-47, (2015)

Rat mammary carcinoma susceptibility 5a1 (Mcs5a1), which is concordant to human MCS5A1 breast cancer risk locus, mediates susceptibility by a non-mammary cell-autonomous mechanism associated with T ce...

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