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长春西汀杂质B

长春西汀杂质B用途

Apovincamine (cis-Apovincamine) 是一种吲哚生物碱,从马来西亚的 Alstonia pneumatophore (Apocynaceae) 分离出来的。Apovincamine 显示抗黑色素生成活性。

长春西汀杂质B名称

[ CAS 号 ]:
4880-92-6

[ 中文名 ]:
阿扑长春胺

[ 英文名 ]:
Apovincamine

[中文别名 ]:

长春西汀杂质B

[英文别名 ]:

Apo-14,15-dehydrovincamine
14,15-dehydrovincamine
Apovincamina [spanish]
eburnamenine-14-carboxylic acid methyl ester
Apovincaminum [latin]
Apovincaminum
Vinpocetine impurity B
Apovincaminic acid methyl
(3S,16S)-Apovincaminsaeure
Apovincamina

长春西汀杂质B生物活性

[ 描述 ]:

Apovincamine (cis-Apovincamine) 是一种吲哚生物碱,从马来西亚的 Alstonia pneumatophore (Apocynaceae) 分离出来的。Apovincamine 显示抗黑色素生成活性。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 其他 >> 其他

[体外研究]

载脂蛋白(顺式载脂蛋白胺；6.3、12.5、25、50、100μM)剂量依赖性抑制细胞活性,IC50为49.8μM,并在B16小鼠黑色素瘤细胞中显示抗黑素生成[1]。

[参考文献]

[1]. Koichiro Koyama, et al. Alpneumines A-H, new anti-melanogenic indole alkaloids from Alstonia pneumatophore. Bioorg Med Chem. 2010 Jun 15;18(12):4415-21.

长春西汀杂质B物理化学性质

[ 密度 ]:
1.3g/cm3

[ 沸点 ]:
405.7ºC at 760mmHg

[ 熔点 ]:
160-162℃

[ 分子式 ]:
C₂₁H₂₄N₂O₂

[ 分子量 ]:
336.42700

[ 闪点 ]:
199.1ºC

[ 精确质量 ]:
336.18400

[ PSA ]:
34.47000

[ LogP ]:
3.69610

[ 折射率 ]:
1.678

长春西汀杂质B毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: JW4793000

CHEMICAL NAME :: Eburnamenine-14-carboxylic acid, methyl ester, (3-alpha,16-alpha)-

CAS REGISTRY NUMBER :: 4880-92-6

LAST UPDATED :: 199806

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C21-H24-N2-O2

MOLECULAR WEIGHT :: 336.47

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FRXXBL French Demande Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #2319362

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4140777

长春西汀杂质B安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

长春西汀杂质B上下游产品

长春西汀杂质B上游产品

长春西汀杂质B下游产品

长春西汀杂质B文献

Effects of aging and vincamine derivatives on pericapillary microenvironment: stereological characterization of the cerebral capillary network.

Neurobiol. Aging 11(1) , 39-46, (1990)

Changes in the pericapillary microenvironment of adult (18-month-old) and senescent (27 1/2-month-old) Fischer-344 rats treated for 6 weeks with daily IP injections of brovincamine or apovincamine (0,...

Alpneumines A-H, new anti-melanogenic indole alkaloids from Alstonia pneumatophora.

Bioorg. Med. Chem. 18(12) , 4415-21, (2010)

Eight new indole alkaloids, alpneumines A-H (1-8) were isolated from the Malaysian Alstonia pneumatophora (Apocynaceae) and their structures were determined by MS and 2D NMR spectroscopic methods. Alp...

Synthesis of vinca alkaloids and related compounds. Part 84. Sulfonamide derivatives of some vinca alkaloids with cardiovascular activity.

Arch. Pharm. (Weinheim) 330(6) , 190-8, (1997)

(+)-Vincamine (1) and (+)-vinpocetine (2) were chlorosulfonylated and the resulting sulfonyl chloride isomers (3-6) were transformed into sulfonamides (7-10). The ester group of sulfonamides was modif...

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