4880-92-6

• 常用中文名：长春西汀杂质B
• 常用英文名：Apovincamine
• CAS号：4880-92-6
• 分子式：C₂₁H₂₄N₂O₂
• 分子量：336.42700
• 相关类别： 分析化学 标准品 药典标准品和杂志标准品
• 发布时间：2018-07-21 16:10:12
• 更新时间：2026-07-02 00:07:18
• Apovincamine (cis-Apovincamine) 是一种吲哚生物碱,从马来西亚的 Alstonia pneumatophore (Apocynaceae) 分离出来的。Apovincamine 显示抗黑色素生成活性。

名称

• 中文名: 阿扑长春胺
• 英文名: Apovincamine
• 中文别名: 长春西汀杂质B 标准品; 长春胺杂质; 长春胺杂质D; 长春西汀相关物质B; 长春西汀相关化合物B; 阿朴长春胺; 顺式-阿扑长春胺
• 英文别名: Methyl (3alpha,16alpha)-eburnamenine-14-cboxylate; 14,15-dehydrovincamine; Vinpocetine impurity B; Vincamine Impurity B; Apovincaminum; Einecs -0; Vinpocetine Related Compound B (30 mg) (methyl (13aS,13bS)-13a-ethyl-9-methoxy-2,3,5,6,13a,13b-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-cboxylate); Methyl (13aS,13bS)-13a-Ethyl-2,3,5; Vinpocetine Impurity B (Vincamine Impurity D); Methyl (13aS,13bS)-13a-Ethyl-2,3,5,6,13a,13b-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]napht; Vincamine Impurity D; Apovincamina; Vinpocetine Related Compound B (Methyl(13aS,13bS)-13a-ethyl-2,3,5,6,13a,13b-hexahydro-1H-indolo[3,2; (3S,16S)-Apovincaminsaeure; Eburnamenine-14-cboxylic acid, methyl ester, (3-alpha,16-alpha); Methyl (13as,13bs)-13A-ethyl-2,3,4,6,13A,14B-hexahydro-1H-indilol(3.2.1-de)pyrido(3,2,1-ij)(1,5)naphthyidin-12-cboxylat; Vinpocetine Impurity B; IMp. B : Methyl (13aS,13bS)-13a-Ethyl-2,3,5,6,13a,13b-hexahydro-1H-indolo[3,2,1- de]pyrido[3,2,1-ij][1,5]naphthyridine-12- cboxylate (ApovincaMine); Vinpocetine Related Compound B; Apovincaminum [latin]; Vinpocetine IMp. B; methyl (41S,13aS)-13a-ethyl-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-cboxylate; methyl (41S,13aS)-13a-ethyl-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]phthyridine-12-cboxylate; methyl(13aS,13bS)-13a-ethyl-2,3,5,6,13a,13b-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-cboxylate(apovincamine); Apo-14,15-dehydrovincamine; Vinpocetine impurity B CRS; Vinpocetine impurity B (apovincamine); Unii-504R182zx7; Eburnamenine-14-cboxylic acid, methyl ester, (3α,16α); (+)-apovincamine, cis-apovincamine; Vinpocetine-2; Apovincaminic acid methyl; Apovincamina [spanish]; (41S,13aS)-methyl 13a-ethyl; Vinpocetine Related Compound B(Secondy Standds traceble to; eburnamenine-14-carboxylic acid methyl ester; Methyl (13aS,13bS)-13a-ethyl-2,3,5,6,13a,13b-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-cboxylate; methyl14,15-didehydrovincane-14-cboxylate(apovincamine); apovincamine; (3α,16α)-Eburnamenine-14-cboxylic acid methyl ester; (+)-trans-Cavinton; cis-ApovincaMine

物化性质

• 密度: 1.3g/cm3
• 沸点: 405.7ºC at 760mmHg
• 熔点: 160-162℃
• 分子式: C₂₁H₂₄N₂O₂
• 分子量: 336.42700
• 闪点: 199.1ºC
• 精确质量: 336.18400
• PSA: 34.47000
• LogP: 3.69610
• 折射率: 1.678

生物活性

• 描述: Apovincamine (cis-Apovincamine) 是一种吲哚生物碱,从马来西亚的 Alstonia pneumatophore (Apocynaceae) 分离出来的。Apovincamine 显示抗黑色素生成活性。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 其他 >> 其他
• 体外研究: 载脂蛋白(顺式载脂蛋白胺；6.3、12.5、25、50、100μM)剂量依赖性抑制细胞活性,IC50为49.8μM,并在B16小鼠黑色素瘤细胞中显示抗黑素生成[1]。
• 参考文献:

  [1]. Koichiro Koyama, et al. Alpneumines A-H, new anti-melanogenic indole alkaloids from Alstonia pneumatophore. Bioorg Med Chem. 2010 Jun 15;18(12):4415-21.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : JW4793000 CHEMICAL NAME : Eburnamenine-14-carboxylic acid, methyl ester, (3-alpha,16-alpha)- CAS REGISTRY NUMBER : 4880-92-6 LAST UPDATED : 199806 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C21-H24-N2-O2 MOLECULAR WEIGHT : 336.47 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 2200 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : FRXXBL French Demande Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #2319362 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >2 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4140777

安全

• 危险品运输编码: NONH for all modes of transport

上下游产品

上游产品  0
下游产品  1
42971-09-5