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5-溴代邻氨基苯甲酸甲酯

5-溴代邻氨基苯甲酸甲酯用途

2-氨基-5-溴苯甲酸甲酯(化合物8/12)可用于合成2-苄氨基苯甲酸,其为已知的FabH抑制剂。该衍生物还抑制PqsD,即铜绿假单胞菌的pqs群体感应(QS)系统,涉及许多毒力因子的产生和生物膜的形成[1]。

5-溴代邻氨基苯甲酸甲酯名称

[ CAS 号 ]:
52727-57-8

[ 中文名 ]:
5-溴氨基苯甲酸甲酯

[ 英文名 ]:
Methyl 2-amino-5-bromobenzoate

[中文别名 ]:

[英文别名 ]:

estere metilico dell'acido 5-bromoantranilico
Methyl 2-amino-5-bromobenzoate
Benzoic acid, 2-amino-5-bromo-, methyl ester
MFCD00144761
Methyl-2-amino-5-brombenzolcarboxylat
2-Amino-5-bromobenzoic Acid Methyl Ester
methyl 2-amino-5-bromo-benzoate
5-Bromoanthranilic Acid Methyl Ester
Methyl 5-Bromoanthranilate
5-bromo-2-amino-benzoic acid methyl ester

5-溴代邻氨基苯甲酸甲酯生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 抗感染 >> 细菌

[参考文献]

[1]. Weidel E, et al. Structure optimization of 2-benzamidobenzoic acids as PqsD inhibitors for Pseudomonas aeruginosa infections and elucidation of binding mode by SPR, STD NMR, and molecular docking. J Med Chem. 2013 Aug 8;56(15):6146-55.

5-溴代邻氨基苯甲酸甲酯物理化学性质

[ 密度 ]:
1.6±0.1 g/cm3

[ 沸点 ]:
286.3±20.0 °C at 760 mmHg

[ 熔点 ]:
72-74 °C(lit.)

[ 分子式 ]:
C₈H₈BrNO₂

[ 分子量 ]:
230.06

[ 闪点 ]:
126.9±21.8 °C

[ 精确质量 ]:
228.973831

[ PSA ]:
52.32000

[ LogP ]:
3.06

[ 外观性状 ]:
白色至淡黄色晶体粉末

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.601

[ 储存条件 ]:
Room temperature.

5-溴代邻氨基苯甲酸甲酯MSDS

详细MSDS(安全技术说明书)

5-溴代邻氨基苯甲酸甲酯安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36-S37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2922499990

5-溴代邻氨基苯甲酸甲酯上下游产品

5-溴代邻氨基苯甲酸甲酯上游产品

5-溴代邻氨基苯甲酸甲酯下游产品

5-溴代邻氨基苯甲酸甲酯海关

[ 海关编码 ]: 2922499990

[ 中文概述 ]:
2922499990 其他氨基酸及其酯及它们的盐（含有一种以上含氧基的除外）. 增值税率:17.0% 退税率:9.0% 监管条件:AB(入境货物通关单,出境货物通关单) 最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: P.进境动植物、动植物产品检疫 Q.出境动植物、动植物产品检疫 R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

5-溴代邻氨基苯甲酸甲酯文献

Structure-activity relationships of new N-acylanthranilic acid derivatives as plasminogen activator inhibitor-1 inhibitors.

Chem. Pharm. Bull. 59(2) , 215-24, (2011)

Novel anthranilic acid derivatives having substituted N-acyl side chains were designed and synthesized for evaluation as plasminogen activator inhibitor-1 (PAI-1) inhibitors. Compounds with a 4-diphen...

Solid-phase preparation of a pilot library derived from the 2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-amine scaffold.

J. Comb. Chem. 9(3) , 487-500, (2007)

A convenient and reliable solid-phase strategy for the synthesis of di- and trisubstituted benzazepine derivatives was developed. 5-Amino-1-tert-butoxycarbonyl-2,3,4,5-tetrahydro-1H-benzo[b]azepine an...

Methyl 2-amino-5-bromobenzoate. Khan I, et al.

Acta Crystallogr. Sect. E Struct. Rep. Online 67(8) , o1887-o1887, (2011)

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