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甲氧基试卤灵

甲氧基试卤灵用途

Resorufin methyl ether (Methoxyresorufin) 是一种细胞色素 P450 的荧光底物,是啮齿动物中 CYP1A2 特异性底物。

甲氧基试卤灵名称

[ CAS 号 ]:
5725-89-3

[ 中文名 ]:
甲氧基异酚恶唑

[ 英文名 ]:
Resorufin methyl ether

[中文别名 ]:

[英文别名 ]:

7-methoxyphenoxazin-3-one
MFCD00037663

甲氧基试卤灵生物活性

[ 描述 ]:

Resorufin methyl ether (Methoxyresorufin) 是一种细胞色素 P450 的荧光底物,是啮齿动物中 CYP1A2 特异性底物。

[ 相关类别 ]:

信号通路 >> 代谢酶/蛋白酶 >> 细胞色素P450

研究领域 >> 其他

[参考文献]

[1]. P V Nerurkar, et al. Methoxyresorufin and benzyloxyresorufin: substrates preferentially metabolized by cytochromes P4501A2 and 2B, respectively, in the rat and mouse. Biochem Pharmacol. 1993 Sep 1;46(5):933-43.

[2]. Hansen Murcia, et al. Study on the inhibitory effect of furafylline and troleandomycin in the 7-methoxyresorufin-O-demethylase and nifedipine oxidase activities in hepatic microsomes from four poultry species using high-performance liquid chromatography coupled with fluorescence and ultraviolet detection. J Pharm Biomed Anal. 2019 Feb 5;164:148-154.

甲氧基试卤灵物理化学性质

[ 密度 ]:
1.33 g/cm3

[ 沸点 ]:
378.8ºC at 760 mmHg

[ 熔点 ]:
≥220ºC(lit.)

[ 分子式 ]:
C₁₃H₉NO₃

[ 分子量 ]:
227.21500

[ 闪点 ]:
187.3ºC

[ 精确质量 ]:
227.05800

[ PSA ]:
52.33000

[ LogP ]:
2.30140

[ 外观性状 ]:
深红色结晶

[ 折射率 ]:
1.638

[ 储存条件 ]:
2-8°C

甲氧基试卤灵MSDS

详细MSDS(安全技术说明书)

甲氧基试卤灵安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2934999090

甲氧基试卤灵上下游产品

甲氧基试卤灵上游产品

甲氧基试卤灵下游产品

甲氧基试卤灵海关

[ 海关编码 ]: 2934999090

[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

甲氧基试卤灵文献

Activation of the aryl hydrocarbon receptor by the widely used Src family kinase inhibitor 4-amino-5-(4-chlorophenyl)-7-(dimethylethyl)pyrazolo[3,4-d]pyrimidine (PP2).

Arch. Toxicol. 89 , 1329-36, (2015)

Small molecular weight protein kinase inhibitors are frequently used tools to unravel the complex network of cellular signal transduction under certain physiological and pathophysiological conditions....

Sex-specific differences in hyperoxic lung injury in mice: role of cytochrome P450 (CYP)1A.

Toxicology 331 , 14-23, (2015)

Sex-specific differences in pulmonary morbidity in adults and preterm infants are well documented. Hyperoxia contributes to lung injury in experimental animals and humans. Cytochrome P450 (CYP) 1A enz...

Effect of commercially available green and black tea beverages on drug-metabolizing enzymes and oxidative stress in Wistar rats.

Food Chem. Toxicol. 70 , 120-7, (2014)

The effect of commercially available green tea (GT) and black tea (BT) drinks on drug metabolizing enzymes (DME) and oxidative stress in rats was investigated. Male Wistar rats were fed a laboratory c...

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