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川楝素

川楝素用途

Toosendanin是从杜鹃花果实皮中提取的一种三萜,具有镇痛、杀虫和抗炎作用。

川楝素名称

[ CAS 号 ]:
58812-37-6

[ 中文名 ]:
川楝素

[ 英文名 ]:
Toosendanin

[中文别名 ]:

苦楝素

[英文别名 ]:

Toosendanin

川楝素生物活性

[ 描述 ]:

Toosendanin是从杜鹃花果实皮中提取的一种三萜,具有镇痛、杀虫和抗炎作用。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 炎症/免疫

[体内研究]

川芎丹宁(0.5和1mg/kg,每日腹腔注射7天)通过抑制M1巨噬细胞极化和调节NLRP3炎性体和Nrf2/HO-1信号传导来减轻DSS诱导的实验性结肠炎,并可能为治疗小鼠结肠炎提供一种新的中药专利药物[1]。动物模型：48只雄性C57BL/6小鼠,体重20-22g[1]。剂量：0.5和1 mg/kg。给药：每日腹腔注射7天。结果：对小鼠DSS诱导的结肠炎有保护作用。抑制DSS诱导的UC中促炎细胞因子的表达并改善氧化应激。

[参考文献]

[1]. Fan H, et al. Toosendanin alleviates dextran sulfate sodium-induced colitis by inhibiting M1 macrophage polarization and regulating NLRP3 inflammasome and Nrf2/HO-1 signaling. Int Immunopharmacol. 2019 Sep 11;76:105909.

川楝素物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
714.0±60.0 °C at 760 mmHg

[ 熔点 ]:
178-180ºC

[ 分子式 ]:
C₃₀H₃₈O₁₁

[ 分子量 ]:
574.616

[ 闪点 ]:
385.6±32.9 °C

[ 精确质量 ]:
574.241394

[ PSA ]:
165.26000

[ LogP ]:
-0.38

[ 外观性状 ]:
白色结晶粉末

[ 蒸汽压 ]:
0.0±2.4 mmHg at 25°C

[ 折射率 ]:
1.619

[ 储存条件 ]:
室温

川楝素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RC1030000

CAS REGISTRY NUMBER :: 58812-37-6

LAST UPDATED :: 199612

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C30-H38-O11

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 98 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CTYAD8 Zhongcaoyao. Chinese Traditional and Herbal Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11- 1980- Volume(issue)/page/year: 13,317,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 244 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CTYAD8 Zhongcaoyao. Chinese Traditional and Herbal Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11- 1980- Volume(issue)/page/year: 13,317,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 13800 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CTYAD8 Zhongcaoyao. Chinese Traditional and Herbal Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11- 1980- Volume(issue)/page/year: 13,317,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 14300 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CTYAD8 Zhongcaoyao. Chinese Traditional and Herbal Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11- 1980- Volume(issue)/page/year: 13,317,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 14600 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CTYAD8 Zhongcaoyao. Chinese Traditional and Herbal Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11- 1980- Volume(issue)/page/year: 13,317,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 4200 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CTYAD8 Zhongcaoyao. Chinese Traditional and Herbal Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11- 1980- Volume(issue)/page/year: 13,317,1982 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Primate - monkey

DOSE/DURATION :: 2500 ug/kg/25D-I

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases

REFERENCE :: CTYAD8 Zhongcaoyao. Chinese Traditional and Herbal Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11- 1980- Volume(issue)/page/year: 13,317,1982

川楝素安全信息

[ 危害码 (欧洲) ]:
Xi

[ 安全声明 (欧洲) ]:
24/25

[ 海关编码 ]:
29389090

川楝素制备

存在于楝科植物川楝和苦楝的树皮和种核中。工艺过程：川楝树皮粉碎、浸提真空浓缩喷雾干燥得粗提物复合溶剂提取制成川楝素杀虫乳油（或加工制成川楝素可湿性粉杀虫剂）。

川楝素