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58812-37-6生产厂家

58812-37-6价格

58812-37-6

58812-37-6结构式
58812-37-6结构式
  • 常用中文名:川楝素
  • 常用英文名:Toosendanin
  • CAS号:58812-37-6
  • 分子式:C30H38O11
  • 分子量:574.616
  • 相关类别: 原料药 抗寄生虫病药 驱肠虫药
  • 发布时间:2018-09-11 18:46:28
  • 更新时间:2024-01-03 11:18:35
  • Toosendanin是从杜鹃花果实皮中提取的一种三萜,具有镇痛、杀虫和抗炎作用。

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中文名 川楝素
英文名 Chuanliansu
中文别名 苦楝素
英文别名 Toosendanin
(1S,2R,4R,5R,6S,8R,10S,11S,12R,14R,15R,16R,19S,21R)-6-(3-Furyl)-12,16,19-trihydroxy-5,11,15-trimethyl-3-oxo-9,17-dioxahexacyclo[13.3.3.0.0.0.0]henicosane-4,21-diyl diacetate
3H-4,11b-propano-1H-oxireno[1',5']cyclopenta[1',2':5,6]naphtho[1,2-c]pyran-11(9H)-one, 10,14-bis(acetyloxy)-9-(3-furanyl)decahydro-3,6,12-trihydroxy-4,6a,9a-trimethyl-, (3R,4R,4aR,6R,6aS,6bS,7aR,9R,9aR,10R,11aR,11bS,12S,14R)-
3H-4,11b-Propano-1H-oxireno[1',5']cyclopenta[1',2':5,6]naphtho[1,2-c]pyran-11(9H)-one, 10,14-bis(acetyloxy)-9-(3-furanyl)decahydro-3,6,12-trihydroxy-4,6a,9a-trimethyl-, (3R,4aR,6R,6aS,6bS,7aR,9S,9aR,10R,11aR,11bS,12S,14R)-
(1S,2R,4R,5R,6S,8R,10S,11S,12R,14R,16R,19S,21R)-6-(3-Furyl)-12,16,19-trihydroxy-5,11,15-trimethyl-3-oxo-9,17-dioxahexacyclo[13.3.3.0.0.0.0]henicosane-4,21-diyl diacetate
3H-4,11b-Propano-1H-oxireno[1',5']cyclopenta[1',2':5,6]naphtho[1,2-c]pyran-11(9H)-one, 10,14-bis(acetyloxy)-9-(3-furanyl)decahydro-3,6,12-trihydroxy-4,6a,9a-trimethyl-, (3R,4R,4aR,6R,6aS,6bS,7aR,9S,9aR,10R,11aR,11bS,12S,14R)-
描述 Toosendanin是从杜鹃花果实皮中提取的一种三萜,具有镇痛、杀虫和抗炎作用。
相关类别
体内研究 川芎丹宁(0.5和1mg/kg,每日腹腔注射7天)通过抑制M1巨噬细胞极化和调节NLRP3炎性体和Nrf2/HO-1信号传导来减轻DSS诱导的实验性结肠炎,并可能为治疗小鼠结肠炎提供一种新的中药专利药物[1]。动物模型:48只雄性C57BL/6小鼠,体重20-22g[1]。剂量:0.5和1 mg/kg。给药:每日腹腔注射7天。结果:对小鼠DSS诱导的结肠炎有保护作用。抑制DSS诱导的UC中促炎细胞因子的表达并改善氧化应激。
参考文献

[1]. Fan H, et al. Toosendanin alleviates dextran sulfate sodium-induced colitis by inhibiting M1 macrophage polarization and regulating NLRP3 inflammasome and Nrf2/HO-1 signaling. Int Immunopharmacol. 2019 Sep 11;76:105909.

密度 1.4±0.1 g/cm3
沸点 714.0±60.0 °C at 760 mmHg
熔点 178-180ºC
分子式 C30H38O11
分子量 574.616
闪点 385.6±32.9 °C
精确质量 574.241394
PSA 165.26000
LogP -0.38
外观性状 白色结晶粉末
蒸汽压 0.0±2.4 mmHg at 25°C
折射率 1.619
储存条件 室温
稳定性

纯品为白色针状晶体,无臭,味苦,易溶于乙醇、乙酸乙酯、丙酮、二氧六环、吡啶等,微溶于热水、氯仿、苯、乙醚等。熔点178~180℃(含一分子结晶水)。

分子结构

1、 摩尔折射率:139.13

2、 摩尔体积(cm3/mol):396.6

3、 等张比容(90.2K):1134.7

4、 表面张力(dyne/cm):66.9

5、 极化率(10-24cm3):55.15

CHEMICAL IDENTIFICATION

RTECS NUMBER :
RC1030000
CAS REGISTRY NUMBER :
58812-37-6
LAST UPDATED :
199612
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C30-H38-O11

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
98 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CTYAD8 Zhongcaoyao. Chinese Traditional and Herbal Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11- 1980- Volume(issue)/page/year: 13,317,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
244 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CTYAD8 Zhongcaoyao. Chinese Traditional and Herbal Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11- 1980- Volume(issue)/page/year: 13,317,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
13800 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CTYAD8 Zhongcaoyao. Chinese Traditional and Herbal Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11- 1980- Volume(issue)/page/year: 13,317,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
14300 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CTYAD8 Zhongcaoyao. Chinese Traditional and Herbal Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11- 1980- Volume(issue)/page/year: 13,317,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
14600 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CTYAD8 Zhongcaoyao. Chinese Traditional and Herbal Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11- 1980- Volume(issue)/page/year: 13,317,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
4200 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CTYAD8 Zhongcaoyao. Chinese Traditional and Herbal Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11- 1980- Volume(issue)/page/year: 13,317,1982 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Primate - monkey
DOSE/DURATION :
2500 ug/kg/25D-I
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases
REFERENCE :
CTYAD8 Zhongcaoyao. Chinese Traditional and Herbal Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11- 1980- Volume(issue)/page/year: 13,317,1982

危害码 (欧洲) Xi
安全声明 (欧洲) 24/25
海关编码 29389090

存在于楝科植物川楝和苦楝的树皮和种核中。工艺过程:川楝树皮粉碎、浸提真空浓缩喷雾干燥得粗提物复合溶剂提取制成川楝素杀虫乳油(或加工制成川楝素可湿性粉杀虫剂)。