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氯非那胺

氯非那胺用途

氯芬酰胺(Aquedux)是一种碳酸酐酶(CA)抑制剂。氯芬酰胺具有利尿作用[1]。

氯非那胺名称

[ CAS 号 ]:
671-95-4

[ 中文名 ]:
氯非那胺

[ 英文名 ]:
clofenamide

[英文别名 ]:

Frictan
Eleklin
4-chloro-benzene-1,3-disulfonic acid diamide
Aponiere
Indigatin
4-Chlor-benzol-1,3-disulfonamid
Haflutan
Monochlorphenamide
4-Chlor-benzol-1,3-disulfonsaeure-diamid
Diumide

氯非那胺生物活性

[ 描述 ]:

氯芬酰胺(Aquedux)是一种碳酸酐酶(CA)抑制剂。氯芬酰胺具有利尿作用[1]。

[ 相关类别 ]:

信号通路 >> 代谢酶/蛋白酶 >> 碳酸酐酶

研究领域 >> 代谢疾病

[参考文献]

[1]. Delbeke FT, et, al. The influence of diuretics on the excretion and metabolism of doping agents. III. Etilamfetamine. Arzneimittelforschung. 1986 Sep;36(9):1413-6.

氯非那胺物理化学性质

[ 密度 ]:
1.699g/cm3

[ 沸点 ]:
551.6ºC at 760 mmHg

[ 熔点 ]:
206-207° (Davies); mp 217-219° (Olivier)

[ 分子式 ]:
C₆H₇ClN₂O₄S₂

[ 分子量 ]:
270.71

[ 闪点 ]:
287.4ºC

[ 精确质量 ]:
269.95400

[ PSA ]:
137.08000

[ LogP ]:
3.19700

[ 折射率 ]:
1.627

氯非那胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CZ9100000

CHEMICAL NAME :: m-Benzenedisulfonamide, 4-chloro-

CAS REGISTRY NUMBER :: 671-95-4

BEILSTEIN REFERENCE NO. :: 2142672

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C6-H7-Cl-N2-O4-S2

MOLECULAR WEIGHT :: 270.72

WISWESSER LINE NOTATION :: ZSWR BG ESZW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 340 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: WRPCA2 World Review of Pest Control. (London, UK) V.1-10, 1962-71. Discontinued. Volume(issue)/page/year: 9,119,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 21,775,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 661 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 21,775,1979

氯非那胺安全信息

[ 海关编码 ]:
2935009090

氯非那胺合成路线

详细合成路线

氯非那胺上下游产品

氯非那胺上游产品

氯非那胺下游产品

氯非那胺海关

[ 海关编码 ]: 2935009090

[ 中文概述 ]:
2935009090 其他磺（酰）胺. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:35.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%