己二酸二异丙酯

己二酸二异丙酯用途

己二酸二异丙酯是一种替代增塑剂和TRPA1活化剂。己二酸二异丙酯激活TRPA1并增强FITC诱导的接触超敏反应(CHS)。己二酸二异丙基酯也是化妆品和药物配方中的一种成分,局部应用于皮肤。己二酸二异丙酯可用作赋形剂,如润肤剂、增塑剂。药用辅料,或称药用辅料,是指除药物成分外,在制药过程中使用的其他化学物质。药用辅料一般是指药物制剂中的非活性成分,可以提高药物制剂的稳定性、溶解性和加工性。药用辅料也会影响联合给药药物的吸收、分布、代谢和消除(ADME)过程[1][2]。

己二酸二异丙酯名称

[ CAS 号 ]:
6938-94-9

[ 中文名 ]:
己二酸二异丙酯

[ 英文名 ]:
Isopropyl adipate

[中文别名 ]:

[英文别名 ]:

Hexanedioic acid, bis(1-methylethyl) ester
MFCD00026391
Diisopropyl adipate
bis(1-methylethyl) hexanedioate
Adipic acid diisopropyl ester
Adipic acid isopropyl ester
Adipic acid, diisopropyl ester
Diisopropyl hexanedioate
Isopropyl adipate
EINECS 230-072-0

己二酸二异丙酯生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> TRP频道

研究领域 >> 其他

[参考文献]

[1]. Kurohane K, et al. Adjuvant Effect of an Alternative Plasticizer, Diisopropyl Adipate, on a Contact Hypersensitivity Mouse Model: Link with Sensory Ion Channel TRPA1 Activation. Biol Pharm Bull. 2015;38(7):1054-62.

[2]. Elder DP, et al. Pharmaceutical excipients - quality, regulatory and biopharmaceutical considerations. Eur J Pharm Sci. 2016 May 25;87:88-99.

己二酸二异丙酯物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
252.6±8.0 °C at 760 mmHg

[ 熔点 ]:
-1 °C

[ 分子式 ]:
C₁₂H₂₂O₄

[ 分子量 ]:
230.30

[ 闪点 ]:
109.8±16.9 °C

[ 精确质量 ]:
230.151810

[ PSA ]:
52.60000

[ LogP ]:
2.79

[ 外观性状 ]:
液体;Colorless to Almost colorless clear liquid

[ 蒸汽压 ]:
0.0±0.5 mmHg at 25°C

[ 折射率 ]:
1.435

[ 储存条件 ]:
室温

己二酸二异丙酯MSDS

详细MSDS(安全技术说明书)

己二酸二异丙酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AV1575000

CHEMICAL NAME :: Adipic acid, diisopropyl ester

CAS REGISTRY NUMBER :: 6938-94-9

BEILSTEIN REFERENCE NO. :: 1785346

LAST UPDATED :: 199710

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C12-H22-O4

MOLECULAR WEIGHT :: 230.34

WISWESSER LINE NOTATION :: 1Y1&OV4VOY1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 3(3),101,1984 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 640 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MRLR** U.S. Army, Chemical Corps Medical Laboratories Research Reports. (Army Chemical Center, Edgewood Arsenal, MD) Volume(issue)/page/year: #256,1954 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - A1241 No. of Facilities: 28 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 1288 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - A1241 No. of Facilities: 423 (estimated) No. of Industries: 3 No. of Occupations: 4 No. of Employees: 4112 (estimated) No. of Female Employees: 2909 (estimated)

己二酸二异丙酯安全信息

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36/37/39

[ RTECS号 ]:
AV1575000

[ 海关编码 ]:
2917120090

己二酸二异丙酯合成路线

详细合成路线

己二酸二异丙酯上下游产品

己二酸二异丙酯上游产品

己二酸二异丙酯下游产品

己二酸二异丙酯海关

[ 海关编码 ]: 2917120090

[ 中文概述 ]:
2917120090. 己二酸及其盐和酯. 增值税率:17.0%. 退税率:13.0%. 监管条件:AB(入境货物通关单,出境货物通关单). 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 对苯二甲酸请注明4-CBA值, 对苯二甲酸请注明P-TL酸值, 对苯二甲酸请注明色度, 对苯二甲酸请注明水分

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验

[ Summary ]:
2917120090. adipic acid and its salts. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0%