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甘氨酰谷氨酸

甘氨酰谷氨酸用途

甘氨酰-L-谷氨酸是一种体内神经营养因子(NF),具有维持乙酰胆碱酯酶含量和活性的功能。甘氨酰-L-谷氨酸不直接作用于乙酰胆碱酯酶的合成,可防止节前神经元变性[1][2]。

甘氨酰谷氨酸名称

[ CAS 号 ]:
7412-78-4

[ 中文名 ]:
甘氨酰-L-谷氨酸

[ 英文名 ]:
β-Endorphin (30-31) (human)

[中文别名 ]:

甘氨酰谷氨酸

[英文别名 ]:

L-Glutamic acid, N-glycyl-
N-glycylglutamic acid
H2N-glycine-Acide glutamique-OH
EINECS 231-019-4
H-Gly-Glu-OH
Glycylglutamic acid
Gly-L-Glu-OH
L-Glutamic acid,N-glycyl
GLY-GLU
MFCD00008128

甘氨酰谷氨酸生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 神经疾病

信号通路 >> 神经信号通路 >> 疼痛

[ 靶点 ]

Acetylcholinesterase

[参考文献]

[1]. Koelle GB, et al. Glycyl-L-glutamine, a precursor, and glycyl-L-glutamic acid, a neurotrophic factor for maintenance of acetylcholinesterase and butyrylcholinesterase in the preganglionically denervated superior cervical ganglion of the cat in vivo. Proc Natl Acad Sci U S A. 1985 Aug;82(15):5213-7.

[2]. Yourick JJ, et al. Regeneration of acetylcholinesterase in clonal neuroblastoma-glioma hybrid NG108-15 cells after soman inhibition: effect of glycyl-L-glutamine. Cell Biol Toxicol. 1991 Jul;7(3):229-37.

甘氨酰谷氨酸物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
536.6±50.0 °C at 760 mmHg

[ 熔点 ]:
155-158ºC (dec.)(lit.)

[ 分子式 ]:
C₇H₁₂N₂O₅

[ 分子量 ]:
204.181

[ 闪点 ]:
278.3±30.1 °C

[ 精确质量 ]:
204.074615

[ PSA ]:
129.72000

[ LogP ]:
-2.68

[ 蒸汽压 ]:
0.0±3.1 mmHg at 25°C

[ 折射率 ]:
1.537

[ 储存条件 ]:
−20°C

甘氨酰谷氨酸MSDS

甘氨酰谷氨酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 安全声明 (欧洲) ]:
24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2924199090

甘氨酰谷氨酸合成路线

甘氨酰谷氨酸上下游产品

甘氨酰谷氨酸上游产品

甘氨酰谷氨酸下游产品

甘氨酰谷氨酸海关

[ 海关编码 ]: 2924199090

[ 中文概述 ]:
2924199090. 其他无环酰胺（包括无环氨基甲酸酯)(包括其衍生物及盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ Summary ]:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

甘氨酰谷氨酸文献

Transport and signaling via the amino acid binding site of the yeast Gap1 amino acid transceptor.

Nat. Chem. Biol. 5 , 45-52, (2009)

Transporter-related nutrient sensors, called transceptors, mediate nutrient activation of signaling pathways through the plasma membrane. The mechanism of action of transporting and nontransporting tr...

Human PEPT1 pharmacophore distinguishes between dipeptide transport and binding.

J. Med. Chem. 49 , 3636-44, (2006)

The human intestinal oligopeptide transporter (PEPT1) facilitates the absorption of dipeptides, tripeptides, and many peptidomimetic drugs. In this study, a large number of peptides were selected to i...

Angiotensin-I-converting enzyme inhibitory peptides: Chemical feature based pharmacophore generation

Eur. J. Med. Chem. 46 , 3428-33, (2011)

A validated 3D pharmacophore model was generated for a series of ACE inhibitory peptides, which consisted of five features (two hydrophobic functions, two hydrogen bond acceptors, and a negative ioniz...

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