3-溴-7-硝基吲哚

3-溴-7-硝基吲哚用途

3-Bromo-7-nitroindazole 是一种有效的,选择性神经元型一氧化氮合酶 (nNOS) 抑制剂,与 eNOS 或诱导型一氧化氮合酶 (iNOS) 相比,其效果更强。3-Bromo-7-nitroindazole 影响整个身体和大脑中的细胞间信使一氧化氮 (NO) 的合成。

3-溴-7-硝基吲哚名称

[ CAS 号 ]:
74209-34-0

[ 中文名 ]:
3-溴-7-硝基吲哚

[ 英文名 ]:
3-Bromo-7-nitro-1H-indazole

[中文别名 ]:

[英文别名 ]:

3-bromo-7-nitro-2H-indazole
3-Bromo-7-nitro-1H-indazole
MFCD00159910
1H-Indazole, 3-bromo-7-nitro-

3-溴-7-硝基吲哚生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 免疫及炎症 >> 一氧化氮合酶

研究领域 >> 神经疾病

[ 靶点 ]

nNOS[1]

[参考文献]

[1]. Gocmez SS, et al. The effect of a selective neuronal nitric oxide synthase inhibitor 3-bromo 7-nitroindazoleon spatial learning and memory in rats. Pharmacol Biochem Behav. 2015 Apr;131:19-25.

3-溴-7-硝基吲哚物理化学性质

[ 密度 ]:
2.0±0.1 g/cm3

[ 沸点 ]:
437.3±25.0 °C at 760 mmHg

[ 熔点 ]:
175-185 °C

[ 分子式 ]:
C₇H₄BrN₃O₂

[ 分子量 ]:
242.030

[ 闪点 ]:
218.3±23.2 °C

[ 精确质量 ]:
240.948685

[ PSA ]:
74.50000

[ LogP ]:
2.52

[ 外观性状 ]:
淡黄色固体

[ 蒸汽压 ]:
0.0±1.0 mmHg at 25°C

[ 折射率 ]:
1.764

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
ethanol: 25 mg/mL

3-溴-7-硝基吲哚MSDS

3-溴-7-硝基吲哚安全信息

[ 符号 ]:

GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H360

[ 警示性声明 ]:
P201-P308 + P313

[ 个人防护装备 ]:
Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T: Toxic;

[ 风险声明 (欧洲) ]:
60

[ 安全声明 (欧洲) ]:
S53-S22-S36/37/39-S45

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2933990090

3-溴-7-硝基吲哚合成路线

3-溴-7-硝基吲哚上下游产品

3-溴-7-硝基吲哚上游产品

3-溴-7-硝基吲哚下游产品

3-溴-7-硝基吲哚海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

3-溴-7-硝基吲哚文献

Metaplastic effects of subanesthetic ketamine on CA1 hippocampal function.

Neuropharmacology 86 , 273-81, (2014)

Ketamine is a non-competitive N-methyl-d-aspartate receptor (NMDAR) antagonist of interest in neuropsychiatry. In the present studies, we examined the effects of subanesthetic, low micromolar ketamine...

Role of nitric oxide in traumatic brain injury in the rat.

J. Neurosurg. 89 , 807-818, (1998)

Although nitric oxide (NO) has been shown to play an important role in the pathophysiological process of cerebral ischemia, its contribution to the pathogenesis of traumatic brain injury (TBI) remains...

7-Nitro indazole derivatives are potent inhibitors of brain, endothelium and inducible isoforms of nitric oxide synthase.

Life Sci. 57 , PL131-PL135, (1995)

The effect of 7-nitro indazole (7-NI) and a range of substituted indazole derivatives on nitric oxide synthase (NOS) enzyme activity in homogenates of rat cerebellum, bovine endothelial cells and lung...

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