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1,4-双((3,5-二氯吡啶-2-基)氧基)苯

1,4-双((3,5-二氯吡啶-2-基)氧基)苯用途

TCPOBOP 是一种组成型雄甾烷受体 (CAR) 激动剂,可诱导强健的肝细胞增殖和肝肿大,无任何肝损伤或组织缺失。TCPOBOP 通过改变 Bcl-2 蛋白减弱 Fas 诱导的小鼠肝损伤。

1,4-双((3,5-二氯吡啶-2-基)氧基)苯名称

[ CAS 号 ]:
76150-91-9

[ 中文名 ]:
1,4-双((3,5-二氯吡啶-2-基)氧基)苯

[ 英文名 ]:
TCPOBOP

[英文别名 ]:

1,4-Bis[2-(3,5-dichloropyridyloxy)]benzene
tcpobop
1,4-BDPOB

1,4-双((3,5-二氯吡啶-2-基)氧基)苯生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 细胞凋亡 >> Bcl-2家族

研究领域 >> 其他

[ 靶点 ]

Bcl-2

[体内研究]

TCPOBOP(口服；3mg/kg；1-5天)在48小时时显著增加LW/BW比率中的肝脏重量与体重[1]。动物模型：MET fl/fl：靶向缺失MET KO外显子16的Tam-Cre +/+小鼠[1]剂量：3mg/kg给药：口服；1,2,5天结果：肝脏重量增加至体重。

[参考文献]

[1]. Bhushan B, et al. TCPOBOP-Induced Hepatomegaly and Hepatocyte Proliferation are Attenuated by Combined Disruption of MET and EGFR Signaling. Hepatology. 2019 Apr;69(4):1702-1718.

[2]. Baskin-Bey ES, et al. Constitutive androstane receptor (CAR) ligand, TCPOBOP, attenuates Fas-induced murine liver injury by altering Bcl-2 proteins. Hepatology. 2006 Jul;44(1):252-62.

1,4-双((3,5-二氯吡啶-2-基)氧基)苯物理化学性质

[ 密度 ]:
1.518g/cm3

[ 沸点 ]:
444.8ºC at 760 mmHg

[ 分子式 ]:
C₁₆H₈Cl₄N₂O₂

[ 分子量 ]:
402.05900

[ 闪点 ]:
222.8ºC

[ 精确质量 ]:
399.93400

[ PSA ]:
44.24000

[ LogP ]:
6.67480

[ 折射率 ]:
1.635

[ 储存条件 ]:
2-8°C，干燥，密封

1,4-双((3,5-二氯吡啶-2-基)氧基)苯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UT7145000

CHEMICAL NAME :: Pyridine, 2,2'-(1,4-phenylenebis(oxy))bis(3,5-dichloro-

CAS REGISTRY NUMBER :: 76150-91-9

LAST UPDATED :: 198910

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C16-H8-Cl4-N2-O2

MOLECULAR WEIGHT :: 402.06

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Unscheduled DNA synthesis

TYPE OF TEST :: Cytogenetic analysis

TYPE OF TEST :: Unscheduled DNA synthesis

TYPE OF TEST :: Cytogenetic analysis

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 10 mg/kg

REFERENCE :: CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 9,1147,1988

1,4-双((3,5-二氯吡啶-2-基)氧基)苯安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 安全声明 (欧洲) ]:
22-24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
UT7145000

1,4-双((3,5-二氯吡啶-2-基)氧基)苯文献

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