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脲酶

脲酶用途

脲酶由多种类型的细菌产生,是一些致病细菌的有效毒力因子。脲酶也是幽门螺杆菌的代谢和毒力的中心,帮助它在胃粘膜中定植[1]。

脲酶名称

[ CAS 号 ]:
9002-13-5

[ 中文名 ]:
尿素酶

[ 英文名 ]:
Urea

[中文别名 ]:

[英文别名 ]:

Carbonyl diamide
Urea
Carbamide
carbonyl diamine
MFCD00070858
Urea (8CI,9CI)

脲酶生物活性

[ 描述 ]:

脲酶由多种类型的细菌产生,是一些致病细菌的有效毒力因子。脲酶也是幽门螺杆菌的代谢和毒力的中心,帮助它在胃粘膜中定植[1]。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 抗感染 >> 细菌

[参考文献]

[1]. Mobley H L T, et al. Urease[J]. Helicobacter pylori: physiology and genetics, 2001: 177-191.

脲酶物理化学性质

[ 密度 ]:
1.6±0.1 g/cm3

[ 沸点 ]:
165.1±23.0 °C at 760 mmHg

[ 分子式 ]:
C₂H₆

[ 分子量 ]:
60.055

[ 闪点 ]:
53.7±22.6 °C

[ 精确质量 ]:
60.032364

[ LogP ]:
-1.43

[ 外观性状 ]:
粉末

[ 蒸汽压 ]:
0.6±0.7 mmHg at 25°C

[ 折射率 ]:
1.528

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
It is slightly soluble in water.

脲酶MSDS

详细MSDS(安全技术说明书)

脲酶毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YU1700000

CHEMICAL NAME :: Urease

CAS REGISTRY NUMBER :: 9002-13-5

LAST UPDATED :: 199701

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 48 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - lacrimation Behavioral - sleep Kidney, Ureter, Bladder - urine volume increased

REFERENCE :: AJPHAP American Journal of Physiology. (American Physiological Soc., 9650 Rockville Pike, Bethesda, MD 20814) V.1- 1898- Volume(issue)/page/year: 206,731,1964

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 20 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold

REFERENCE :: AJPHAP American Journal of Physiology. (American Physiological Soc., 9650 Rockville Pike, Bethesda, MD 20814) V.1- 1898- Volume(issue)/page/year: 206,731,1964

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - lacrimation Behavioral - sleep Kidney, Ureter, Bladder - urine volume increased

REFERENCE :: AJPHAP American Journal of Physiology. (American Physiological Soc., 9650 Rockville Pike, Bethesda, MD 20814) V.1- 1898- Volume(issue)/page/year: 206,731,1964

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 58 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AJPHAP American Journal of Physiology. (American Physiological Soc., 9650 Rockville Pike, Bethesda, MD 20814) V.1- 1898- Volume(issue)/page/year: 206,731,1964

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 25 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - lacrimation Behavioral - sleep Kidney, Ureter, Bladder - urine volume increased

REFERENCE :: AJPHAP American Journal of Physiology. (American Physiological Soc., 9650 Rockville Pike, Bethesda, MD 20814) V.1- 1898- Volume(issue)/page/year: 206,731,1964

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 6 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: AJPHAP American Journal of Physiology. (American Physiological Soc., 9650 Rockville Pike, Bethesda, MD 20814) V.1- 1898- Volume(issue)/page/year: 206,731,1964

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 35 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - lacrimation Behavioral - sleep Kidney, Ureter, Bladder - urine volume increased

REFERENCE :: AJPHAP American Journal of Physiology. (American Physiological Soc., 9650 Rockville Pike, Bethesda, MD 20814) V.1- 1898- Volume(issue)/page/year: 206,731,1964 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3123 No. of Facilities: 1133 (estimated) No. of Industries: 3 No. of Occupations: 9 No. of Employees: 14585 (estimated) No. of Female Employees: 9975 (estimated)

脲酶安全信息

[ 符号 ]:

GHS07, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H315-H319-H334-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338-P342 + P311

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S22-S24-S26-S36/37-S45-S36-S23

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
1

[ RTECS号 ]:
YU1700000

脲酶制备

1.以刀豆粉为原料，经丙酮抽提后过滤、离心、重结晶得产品

由非致病性、非产毒性细菌——发酵乳杆菌(Lactobacillus frmentum)用GR.AS的各种培养材料进行纯种培养后分离而得

脲酶文献

Efficiency of utilization of nitrogen coated with urease inhibitor in maize.

Pak. J. Biol. Sci. 16(17) , 871-6, (2013)

This study aimed to evaluate under field conditions the efficiency in the use ofN coated with urease inhibitor in maize. The experiment was conducted in the year of 2007/2008. The experimental design ...

Study of alpha-amylase and urease inhibitory activities of Melilotus indicus (Linn.) All.

Pak. J. Pharm. Sci. 27(1) , 57-61, (2014)

Melilotus indicus (Linn.) All. is a small herb distributed throughout Pakistan and has a number of ethnomedicinal uses. It is also consumed as a vegetable. In the present work, we are reporting the al...

Effects of the halophytes Tecticornia indica and Suaeda fruticosa on soil enzyme activities in a Mediterranean Sabkha.

Int. J. Phytoremediation 15(2) , 188-97, (2013)

In the present work, we studied the effectiveness of the predominant halophytes of Soliman sabkha (Tecticornia indica and Suaeda fruticosa) to promote soil biological activities and ecosystem producti...

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脲酶