99294-93-6

• 常用中文名：酒石酸唑吡坦
• 常用英文名：Stilnox
• CAS号：99294-93-6
• 分子式：C₂₃H₂₇N₃O₇
• 分子量：764.866
• 相关类别： 原料药 神经系统用药 2镇静与催眠药
• 发布时间：2018-02-08 08:00:00
• 更新时间：2024-01-02 17:44:27
• 用途一：催眠药
  用途二：用于失眠症的治疗
  

名称

• 中文名: 酒石酸唑吡坦
• 英文名: zolpidem tartrate
• 中文别名: 2-(4-甲基苯基)-N,N,6-三甲基咪唑并[1,2-a]吡啶-3-乙酰胺酒石酸盐
• 英文别名: (2R,3R)-2,3-Dihydroxybutandisäure--N,N-dimethyl-2-[6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridin-3-yl]acetamid(1:2); Cymerion; Myslee; zoliprofen; Eudorm; Butanedioic acid, 2,3-dihydroxy-, (2R,3R)-, compd. with N,N,6-trimethyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine-3-acetamide (1:2); N,N-dimethyl-2-[6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridin-3-yl]acetamide 2,3-dihydroxybutanedioate (2:1) (salt); Zoliprofenum [INN-Latin]; Bilcam; Dalparan; N,N,6-Trimethyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine-3-acetamide L-(+)-Tartrate (2:1); 2-(4-(2-Thiazolyloxy)phenyl)propionic acid; ( inverted exclamation markA)-2-(4-(2-thiazolyloxy)phenyl)propionic acid; Somit; N,N-dimethyl-2-[6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridin-3-yl]acetamide 2,3-dihydroxybutanedioate (2:1); Zolpidem L-(+)-hemitartrate; MFCD00214408; Zoliprofene [INN-French]; Stilnox; Zolpidem hemitartrate; (2R,3R)-2,3-Dihydroxysuccinic acid - N,N-dimethyl-2-[6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridin-3-yl]acetamide (1:2); Ivadal; EINECS 200-659-6; 2-(4-thiazol-2-yloxy-phenyl)-propionic acid; SL 800750-23N; acide (2R,3R)-2,3-dihydroxybutanedioïque - N,N-diméthyl-2-[6-méthyl-2-(4-méthylphényl)imidazo[1,2-a]pyridin-3-yl]acétamide (1:2); Zoliprofeno [INN-Spanish]; Stilnoct; Zolpidem tartrate; Durnit; N,N-dimethyl-2-[6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridin-3-yl]acetamide (R-(R*,R*))-2,3-Dihydroxybutanedioate (2:1); Stimox; Sumenan; Niotal

物化性质

• 熔点: 196ºC /Zolpidem/
• 分子式: C₂₃H₂₇N₃O₇
• 分子量: 764.866
• 精确质量: 764.353333
• PSA: 152.67000
• LogP: 1.12620
• 外观性状: 白色至灰白色结晶粉末
• 储存条件: 2-8°C

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : NJ5109800 CAS REGISTRY NUMBER : 99294-93-6 LAST UPDATED : 199712 DATA ITEMS CITED : 9 MOLECULAR FORMULA : C38-H42-N6-O2.C8-H12-O12 MOLECULAR WEIGHT : 915.06 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - child DOSE/DURATION : 500 ug/kg TOXIC EFFECTS : Behavioral - hallucinations, distorted perceptions REFERENCE : JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.19- 1982- Volume(issue)/page/year: 35,453,1997 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - child DOSE/DURATION : 5 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Cardiac - pulse rate increase, without fall in BP REFERENCE : JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.19- 1982- Volume(issue)/page/year: 35,453,1997 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - man DOSE/DURATION : 143 ug/kg TOXIC EFFECTS : Behavioral - altered sleep time (including change in righting reflex) REFERENCE : JCPYDR Journal of Clinical Pyschopharmacology. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1981- Volume(issue)/page/year: 14,150,1994 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - man DOSE/DURATION : 4286 ug/kg TOXIC EFFECTS : Behavioral - coma Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - bronchiolar constriction REFERENCE : HETOEA Human & Experimental Toxicology. (Macmillan Press Ltd., Brunel Road, Houndmills, Basingstoke, Hampshire, RG21 2XS, UK) V.9- 1990- Volume(issue)/page/year: 9,105,1990 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - woman DOSE/DURATION : 200 ug/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - visual field changes Behavioral - hallucinations, distorted perceptions REFERENCE : LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 342,443,1993 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human DOSE/DURATION : 857 ug/kg TOXIC EFFECTS : Cardiac - pulse rate increase, without fall in BP Vascular - BP lowering not characterized in autonomic section REFERENCE : JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.19- 1982- Volume(issue)/page/year: 32,391,1994 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 2700 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.19- 1982- Volume(issue)/page/year: 32,391,1994 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 695 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.19- 1982- Volume(issue)/page/year: 32,391,1994 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 55 mg/kg SEX/DURATION : female 7-17 day(s) after conception TOXIC EFFECTS : Reproductive - Maternal Effects - other effects Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) REFERENCE : KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 27,137,1993

安全

• 符号: GHS02, GHS06, GHS08
• 信号词: Danger
• 危害声明: H225-H301 + H311 + H331-H370
• 警示性声明: P210-P260-P280-P301 + P310-P311
• 危害码 (欧洲): Xi
• 风险声明 (欧洲): R36/37/38
• 安全声明 (欧洲): 26-36
• 危险品运输编码: UN1230 - class 3 - PG 2 - Methanol, solution
• 闪点（华氏）: 48.2 °F
• 闪点（摄氏）: 9 °C