1225-60-1

• 常用中文名：盐酸异西喷他
• 常用英文名：Isothipendyl hydrochloride
• CAS号：1225-60-1
• 分子式：C₁₆H₂₀ClN₃S
• 分子量：321.86800
• 发布时间：2018-10-03 19:10:32
• 更新时间：2024-01-13 16:13:23
• Isothipendyl hydrochloride is a 1st generation H1 antagonist (antihistamine) and anticholinergic used as an antipruritic.

名称

• 中文名: 盐酸异西喷他
• 英文名: isothipendyl hydrochloride
• 英文别名: 10-(2-dimethylamine-2-methyl ethyl)-10H-pyrido[3,2-b][1,4-benzothiazine] hydrochloride; (2-benzo[b]pyrido[2,3-e][1,4]thiazin-10-yl-1-methyl-ethyl)-dimethyl-amine,monohydrochloride; 10H-Pyrido[3,2-b][1,4]benzothiazine-10-ethanamine,N,N,a-trimethyl-,monohydrochloride (9CI); N,N-dimethyl-1-pyrido[3,2-b][1,4]benzothiazin-10-yl-propan-2-amine hydrochloride; dimethyl-(1-methyl-2-pyrido[3,2-b][1,4]benzothiazin-10-yl-ethyl)amine hydrochloride

物化性质

• 沸点: 421.3ºC at 760 mmHg
• 分子式: C₁₆H₂₀ClN₃S
• 分子量: 321.86800
• 闪点: 208.6ºC
• 精确质量: 321.10700
• PSA: 44.67000
• LogP: 4.50140
• 蒸汽压: 2.63E-07mmHg at 25°C
• 储存条件: 库房通风低温干燥,与食品原料分开存放

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : UU8568000 CHEMICAL NAME : 10H-Pyrido(3,2-b)(1,4)benzothiazine, 10-(2-dimethylamino-2-methylethyl)-, hydrochloride CAS REGISTRY NUMBER : 1225-60-1 LAST UPDATED : 199603 DATA ITEMS CITED : 8 MOLECULAR FORMULA : C16-H19-N3-S.Cl-H MOLECULAR WEIGHT : 321.90 WISWESSER LINE NOTATION : T C666 BN DN ISJ B1Y1&N1&1 &GH HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1220 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 7,237,1957 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 206 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 22,375,1980 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 206 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 7,237,1957 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 222 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 7,237,1957 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 62 mg/kg TOXIC EFFECTS : Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 7,237,1957 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 86 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 7,237,1957 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 28 mg/kg TOXIC EFFECTS : Behavioral - tremor Behavioral - convulsions or effect on seizure threshold REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 7,237,1957 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 41 mg/kg TOXIC EFFECTS : Behavioral - tremor Behavioral - convulsions or effect on seizure threshold REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 7,237,1957