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相关CAS号：
1910-68-5 1084-65-7
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1910-68-5

1910-68-5结构式
1910-68-5结构式
  • 常用中文名：美替沙腙
  • 常用英文名：N-METHYLISATIN-3-THIOSEMICARBAZONE
  • CAS号：1910-68-5
  • 分子式：C10H10N4OS
  • 分子量：234.28
  • 相关类别： 化学试剂 有机试剂 腙
  • 发布时间：2018-08-15 18:21:02
  • 更新时间：2024-01-08 15:28:48
  • 甲硫腙(Marboran)是一种抗病毒药物,通过抑制mRNA和蛋白质合成发挥作用。甲苯胺酮也是一种SARS-CoV-2(2019冠状病毒疾病)抑制剂。甲苯胺酮主要用于痘病毒[1]。

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中文名 美替沙腙
英文名 Metisazone
中文别名 肼硫代羰酰胺,2-(1,2-二氢-1-甲基-2-氧代-3H-吲哚-3-亚基)
英文别名 Metisazon
Viruzona
Metisazonum
N-methylisatin-3-thiosemicarbazone
methisazone
[(1-methyl-2-oxoindol-3-ylidene)amino]thiourea
[(Z)-(1-methyl-2-oxoindol-3-ylidene)amino]thiourea
Marboran
N-Methylisatin thiosemicarbazone
Kemoviran
描述 甲硫腙(Marboran)是一种抗病毒药物,通过抑制mRNA和蛋白质合成发挥作用。甲苯胺酮也是一种SARS-CoV-2(2019冠状病毒疾病)抑制剂。甲苯胺酮主要用于痘病毒[1]。
相关类别
参考文献

[1]. Bhumi Shah, et al. In silico studies on therapeutic agents for COVID-19: Drug repurposing approach. Life Sci. 2020 Jul 1;252:117652.
密度 1.47 g/cm3
沸点 410.3ºC at 760 mmHg
熔点 245°
分子式 C10H10N4OS
分子量 234.28
闪点 202ºC
精确质量 234.05800
PSA 102.81000
LogP 1.35650
蒸汽压 6.07E-07mmHg at 25°C
折射率 1.732
Name: n-Methylisatin 3-(thiosemicarbazone) 96% Material Safety Data Sheet
Synonym: Methisazon
CAS: 1910-68-5
Section 1 - Chemical Product MSDS Name:n-Methylisatin 3-(thiosemicarbazone) 96% Material Safety Data Sheet
Synonym:Methisazon
Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
1910-68-5 N-Methylisatin 3-(thiosemicarbazone), 217-616-2
Hazard Symbols: Not available.
Risk Phrases:
Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Appearance: Target Organs: None.
Potential Health Effects
The toxicological properties of this material have not been investigated. Use appropriate procedures to prevent opportunities for direct contact with the skin or eyes and to prevent inhalation.
Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.
Skin:
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
Remove contaminated clothing and shoes.
Ingestion:
If victim is conscious and alert, give 2-4 cupfuls of milk or water.
Get medical aid immediately.
Inhalation:
Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Notes to Physician:
Treat symptomatically and supportively.
Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media:
In case of fire, use water, dry chemical, chemical foam, or alcohol-resistant foam.
Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Clean up spills immediately, observing precautions in the Protective Equipment section. Sweep up, then place into a suitable container for disposal.
Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation.
Storage:
Store in a cool, dry place. Keep container closed when not in use.
Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits. Use process enclosure, local exhaust ventilation, or other engineering controls to control airborne levels.
Exposure Limits +--------------------+-------------------+-------------------+-----------------+ | Chemical Name | ACGIH | NIOSH |OSHA - Final PELs| |--------------------|-------------------|-------------------|-----------------| | N-Methylisatin 3-(t|none listed |none listed |none listed | | hiosemicarbazone), | | | | | 96% | | | | +--------------------+-------------------+-------------------+-----------------+ OSHA Vacated PELs: N-Methylisatin 3-(thiosemicarbazone), 96%: No OSHA Vacated PELs are listed for this chemical.
Personal Protective Equipment Eyes: Wear safety glasses and chemical goggles if splashing is possible.
Skin:
Wear appropriate protective gloves and clothing to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to minimize contact with skin.
Respirators:
Wear a NIOSH/MSHA or European Standard EN 149 approved full-facepiece airline respirator in the positive pressure mode with emergency escape provisions.
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Not available.
Appearance: not available
Odor: None reported.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: @ 760.00mm Hg
Freezing/Melting Point: 235 deg C
Autoignition Temperature: Not available.
Flash Point: Not available.
NFPA Rating: Not published.
Explosion Limits, Lower: Not available.
Upper: Not available.
Decomposition Temperature:
Solubility:
Specific Gravity/Density:
Molecular Formula: C10H10N4OS
Molecular Weight: 234.28
Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials, strong oxidants.
Incompatibilities with Other Materials:
Not available.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, oxides of sulfur, irritating and toxic fumes and gases, carbon dioxide, nitrogen.
Hazardous Polymerization: Has not been reported.
Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 1910-68-5: NL7960000 LD50/LC50:
CAS# 1910-68-5: Oral, mouse: LD50 = 4 gm/kg.
Carcinogenicity:
N-Methylisatin 3-(thiosemicarbazone), 96% - Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA.
See actual entry in RTECS for complete information.
Section 12 - ECOLOGICAL INFORMATION

Section 13 - DISPOSAL CONSIDERATIONS
Chemical waste generators must determine whether a discarded chemical is classif as a hazardous waste.
US EPA guidelines for the classification determination are listed in 40 CFR Part Additionally, waste generators must consult state and local hazardous waste regu ensure complete and accurate classification.
RCRA P-Series: None listed.
RCRA U-Series: None listed.
Section 14 - TRANSPORT INFORMATION

CDG/CPL
Not classified as hazardous for supply.
Canadian TDG
No information available.
Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: Not available.
Risk Phrases:
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
WGK (Water Danger/Protection)
CAS# 1910-68-5: No information available.
United Kingdom Occupational Exposure Limits
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
WHMIS: Not available.
CAS# 1910-68-5 is not listed on Canada's Ingredient Disclosure List.
Exposure Limits
US FEDERAL
TSCA
CAS# 1910-68-5 is not listed on the TSCA inventory.
It is for research and development use only.
Health & Safety Reporting List
None of the chemicals are on the Health & Safety Reporting List.
Chemical Test Rules
None of the chemicals in this product are under a Chemical Test Rule.
Section 12b
None of the chemicals are listed under TSCA Section 12b.
TSCA Significant New Use Rule
None of the chemicals in this material have a SNUR under TSCA.
SARA
Section 302 (RQ)
None of the chemicals in this material have an RQ.
Section 302 (TPQ)
None of the chemicals in this product have a TPQ.
Section 313
No chemicals are reportable under Section 313.
Clean Air Act:
This material does not contain any hazardous air pollutants.
This material does not contain any Class 1 Ozone depletors.

SECTION 16 - ADDITIONAL INFORMATION
N/A

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NL7960000
CHEMICAL NAME :
Indole-2,3-dione, 1-methyl-, 3-(thiosemicarbazone)
CAS REGISTRY NUMBER :
1910-68-5
LAST UPDATED :
199106
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C10-H10-N4-O-S
MOLECULAR WEIGHT :
234.30
WISWESSER LINE NOTATION :
T56 BNVYJ B1 DUNMYZUS

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
4 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>50 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
56 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
DNA damage
TEST SYSTEM :
Human HeLa cell
DOSE/DURATION :
30 umol/L
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 25,821,1976

海关编码 2933790090
上游产品  4

下游产品  0

海关编码 2933790090
中文概述 2933790090 其他内酰胺. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:9.0% 普通关税:20.0%
申报要素 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary 2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0%

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