14729-29-4

• 常用中文名：roridin a
• 常用英文名：roridin a
• CAS号：14729-29-4
• 分子式：C₂₉H₄₀O₉
• 分子量：532.62200
• 发布时间：2017-03-12 07:42:27
• 更新时间：2024-01-09 00:00:42
• Roridin A是拟南芥花粉发育的抑制剂。Roridin A是从真菌Cylindrocarpon sp.中分离出来的。Roridin A在浓度为2μM时抑制花粉发育[1]。

名称

• 中文名: 7'-去氧代-7'-[(1R)-1-羟基乙基]-(7'R)-疣孢菌素 A
• 英文名: roridin a
• 英文别名: roridin A from myrothecium sp cryst; roridana; Roridin A,Roridin C; roridinea; Einecs 238-783-8; roridin a from myrothecium sp.; MFCD00055569; 7'-Deoxo-7'-[(1R)-1-Hydroxyethyl]-(7'R)-Verrucarin A

物化性质

• 密度: 1.29g/cm3
• 沸点: 752.4ºC at 760 mmHg
• 分子式: C₂₉H₄₀O₉
• 分子量: 532.62200
• 闪点: 246ºC
• 精确质量: 532.26700
• PSA: 124.05000
• LogP: 2.39340
• 外观性状: 粉末
• 蒸汽压: 3.92E-26mmHg at 25°C
• 折射率: 1.58

生物活性

• 描述: Roridin A是拟南芥花粉发育的抑制剂。Roridin A是从真菌Cylindrocarpon sp.中分离出来的。Roridin A在浓度为2μM时抑制花粉发育[1]。
• 相关类别:
  研究领域 >> 其他
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. AtsumiShimada, et al. Roridin A and verrucarin A, inhibitors of pollen development in Arabidopsis thaliana, produced by Cylindrocarpon sp.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : VL0355000 CHEMICAL NAME : Roridin A CAS REGISTRY NUMBER : 14729-29-4 LAST UPDATED : 198708 DATA ITEMS CITED : 5 MOLECULAR FORMULA : C29-H40-O9 MOLECULAR WEIGHT : 532.69 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : Standard Draize test ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - guinea pig REFERENCE : FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 4,S124,1984 ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 9 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - muscle contraction or spasticity REFERENCE : TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962- Volume(issue)/page/year: 23,731,1985 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 500 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DFSCDX Developments in Food Science. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1978- Volume(issue)/page/year: 4,135,1983 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : BIBIAU Biotechnology and Bioengineering. (John Wiley & Sons, Inc., 605 Third Ave., New York, NY 10158) V.4- 1962- Volume(issue)/page/year: 10,445,1968 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 2300 ug/kg TOXIC EFFECTS : Gastrointestinal - ulceration or bleeding from large intestine Gastrointestinal - hypermotility, diarrhea REFERENCE : TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962- Volume(issue)/page/year: 23,731,1985

安全

• 危害码 (欧洲): T+: Very toxic;
• 风险声明 (欧洲): R28
• 安全声明 (欧洲): 28-36/37-45
• 危险品运输编码: UN 3462 6.1/PG 1
• 危险类别: 6.1(a)

合成路线

76685-82-0 ~% 3148-09-2 16891-85-3 14729-29-4 详细

文献：Jarvis, Bruce B.; Pavanasasivam, Gowsala; Holmlund, C. E.; DeSilva, Tuley; Stahly, G. Patrick; Mazzola, Eugene P. Journal of the American Chemical Society, 1981 , vol. 103, # 2 p. 472 - 474

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