56392-16-6

• 常用中文名：α-羟基美托洛尔(非对映异构体混合物)
• 常用英文名：UNII:C19D0413EL
• CAS号：56392-16-6
• 分子式：C₁₅H₂₅NO₄
• 分子量：283.363
• 相关类别： 分析化学 分析试剂 离子色谱试剂
• 发布时间：2018-08-26 18:01:14
• 更新时间：2026-07-03 15:16:09
• a-Hydroxymetoprolol 是美托洛尔的代谢产物。a-Hydroxymetoprolol 对美托洛尔的肾上腺素受体阻断作用几乎为零。

名称

• 中文名: A-羟基美托洛尔
• 英文名: α-Hydroxy Metoprolol
• 中文别名: Α-羟基美托洛(含有异构体); 化合物 Α-HYDROXY METOPROLOL; Α-羟美托洛尔; 甲羟美托洛尔; A-羟基美托洛尔/非对映体混合物; Α-羟基美托洛尔; Α-羟基美托洛尔/精确称量; Α-羟基美托洛; Α-羟基美托洛尔(非对映异构体混合物); Alpha-羟基美托洛尔; 甲羟基美托洛尔
• 英文别名: alpha-Hydroxy Metoprolol (Mixture of Diastereomers); alpha-Hydroxymetoprolol (mixture of stereoisomers); 3-[4-(1-Hydroxy-2-methoxyethyl)phenoxy]-1-isopropylamino-2-propanol; α-Hydroxy Metoprolol (Mixture of Diastereomers); alpha-Hydroxymetoprolol (unlabelled) (mixture of stereoisomers); α-Hydroxymetoprolol(mixtureofstereoisomers); Benzenemethanol, 4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]-α-(methoxymethyl); alpha-Hydroxymetoprolol(unlabelled); α-HYDROXYMETOPROLOL; α-Hydroxymetoprolol in methanol; (±)-a-HydroxyMetoprolol-d7; α-Hydroxy MetoprololQ: What is α-Hydroxy Metoprolol Q: What is the CAS Number of α-Hydroxy Metoprolol Q: What is the storage condition of α-Hydroxy Metoprolol Q: What e the applications of α-Hydroxy Metoprolol; 1-(4-(1-hydroxy-2-methoxyethyl)phenoxy)-3-(isopropylamino)propan-2-ol; a-Hydroxymetoprolo; alpha-Hydroxy Metoprolol/1-(4-(1-Hydroxy-2-methoxyethyl)phenoxy)-3-(isopropylamino)propan-2-ol; ALPHA-HYDROXYMETOPROLOL; 1-[4-(2-Methoxy-1-hydroxyethyl)phenoxy]-3-(isopropylamino)-2-propanol; 1-[4-(1-hydroxy-2-methoxyethyl)phenoxy]-3-(isopropylamino)propan-2-ol; h119/66; α-Hydroxymetoprolol (unlabelled); h119-66; 1-[4-(1-Hydroxy-2-methoxyethyl)phenoxy]-3-(isopropylamino)-2-propanol; a-Hydroxy Metoprolol (Mixture of Diastereomers); Alpha Hydroxy Metoprolol succinate; 4-[2-Hydroxy-3-[(1-methylethyl)amino]propoxy]-a-(methoxymethyl)-benzenemethan- ol; α-Hydroxymetoprolol (unlabelled) (mixture of stereoisomers); 4-[2-Hydroxy-3-[(1-methylethyl)amino]propoxy]-α-(methoxymethyl)benzenemethanol; benzenemethanol,4-(2-hydroxy-3-((1-methylethyl)amino)propoxy)-alpha-(methoxyme; a-Hydroxymetoprolol; Alpha-Hydroxy Metoprolol-d6; α-Hydroxymetoprolol (mixture of stereoisomers)

物化性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 437.6±45.0 °C at 760 mmHg
• 熔点: 65-67ºC
• 分子式: C₁₅H₂₅NO₄
• 分子量: 283.363
• 闪点: 218.4±28.7 °C
• 精确质量: 283.178345
• PSA: 70.95000
• LogP: 0.72
• 外观性状: 白色固体
• 蒸汽压: 0.0±1.1 mmHg at 25°C
• 折射率: 1.524
• 储存条件: -20°C Freezer

生物活性

• 描述: a-Hydroxymetoprolol 是美托洛尔的代谢产物。a-Hydroxymetoprolol 对美托洛尔的肾上腺素受体阻断作用几乎为零。
• 相关类别:
  研究领域 >> 其他
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. Hoffmann KJ, et al. The effect of impaired renal function on the plasma concentration and urinary excretion of metoprolol metabolites. Clin Pharmacokinet. 1980 Mar-Apr;5(2):181-91.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : DA4907000 CHEMICAL NAME : Benzenemethanol, 4-(2-hydroxy-3-((1-methylethyl)amino)propoxy)-alpha-( methoxymethyl)- CAS REGISTRY NUMBER : 56392-16-6 LAST UPDATED : 198809 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C15-H25-N-O4 MOLECULAR WEIGHT : 283.41 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 200 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PBPSDY Pharmacological and Biochemical Properties of Drug Substances. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.1- 1977- Volume(issue)/page/year: 2,186,1979

安全

• 危险品运输编码: NONH for all modes of transport

合成路线

110458-45-2 ~95% 56392-16-6

文献：Shetty, H. Umesha; Nelson, Wendel L. Journal of Medicinal Chemistry, 1988 , vol. 31, # 1 p. 55 - 59

2491-38-5 ~% 56392-16-6

文献：Journal of Medicinal Chemistry, , vol. 31, # 1 p. 55 - 59

32136-81-5 ~% 56392-16-6

文献：Journal of Medicinal Chemistry, , vol. 31, # 1 p. 55 - 59

110458-44-1 ~% 56392-16-6

文献：Journal of Medicinal Chemistry, , vol. 31, # 1 p. 55 - 59

110458-43-0 ~% 56392-16-6

文献：Journal of Medicinal Chemistry, , vol. 31, # 1 p. 55 - 59

110458-42-9 ~% 56392-16-6

文献：Journal of Medicinal Chemistry, , vol. 31, # 1 p. 55 - 59

51384-51-1 ~% 56392-16-6

文献：European Journal of Clinical Pharmacology, , vol. 59, # 5-6 p. 429 - 442

上下游产品

上游产品  6
110458-45-2 2491-38-5 32136-81-5 110458-44-1
110458-43-0 51384-51-1
下游产品  0