361444-66-8

• 常用中文名：JDTic
• 常用英文名：JDTic
• CAS号：361444-66-8
• 分子式：C₂₈H₃₉N₃O₃
• 分子量：465.628
• 相关类别： 信号通路 G 蛋白偶联受体/G 蛋白 阿片受体
• 发布时间：2017-03-06 00:59:33
• 更新时间：2024-01-10 11:35:40
• JDTic是κ-阿片受体拮抗剂,对μ-和δ-阿片受体无作用。

名称

• 中文名: JDTic
• 英文名: (3R)-7-hydroxy-N-[(2S)-1-[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]-3-methylbutan-2-yl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide
• 英文别名: CS-0537; JDTic; JDC; 3-Isoquinolinecarboxamide, 1,2,3,4-tetrahydro-7-hydroxy-N-[(1S)-1-[[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl]-2-methylpropyl]-, (3R)-; (3R)-7-Hydroxy-N-{(2S)-1-[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]-3-methyl-2-butanyl}-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide; (3r)-7-Hydroxy-N-{(2s)-1-[(3r,4r)-4-(3-Hydroxyphenyl)-3,4-Dimethylpiperidin-1-Yl]-3-Methylbutan-2-Yl}-1,2,3,4-Tetrahydroisoquinoline-3-Carboxamide

物化性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 701.9±60.0 °C at 760 mmHg
• 分子式: C₂₈H₃₉N₃O₃
• 分子量: 465.628
• 闪点: 378.3±32.9 °C
• 精确质量: 465.299133
• PSA: 88.32000
• LogP: 3.00
• 蒸汽压: 0.0±2.3 mmHg at 25°C
• 折射率: 1.570
• 储存条件: 2-8℃

生物活性

• 描述: JDTic是κ-阿片受体拮抗剂,对μ-和δ-阿片受体无作用。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 阿片受体
  信号通路 >> 神经信号通路 >> 阿片受体
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Thomas, James B. et al. Importance of Phenolic Address Groups in Opioid Kappa Receptor Selective Antagonists. Journal of Medicinal Chemistry (2004), 47(4), 1070-1073.

  [2]. Jackson KJ, Carroll FI, Negus SS, Damaj MI. Effect of the selective kappa-opioid receptor antagonist JDTic on nicotine antinociception, reward, and withdrawal in the mouse. Psychopharmacology (Berl). 2010 Jun;210(2):285-94.

  [3]. Beardsley PM, Pollard GT, Howard JL, Carroll FI. Effectiveness of analogs of the kappa opioid receptor antagonist (3R)-7-hydroxy-N-((1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl)-1,2,3,4-tetrahydro-3-isoquinolinec

  [4]. Deehan GA Jr, McKinzie DL, Carroll FI, McBride WJ, Rodd ZA. The long-lasting effects of JDTic, a kappa opioid receptor antagonist, on the expression of ethanol-seeking behavior and the relapse drinking of female alcohol-preferring (P) rats. Pharmacol Bi

  [5]. Wu H, Wacker D, Mileni M, Katritch V, Han GW, Vardy E, Liu W, Thompson AA, Huang XP, Carroll FI, Mascarella SW, Westkaemper RB, Mosier PD, Roth BL, Cherezov V, Stevens RC. Structure of the human κ-opioid receptor in complex with JDTic. Nature. 2012 Mar