3583-64-0

• 常用中文名：布马地宗
• 常用英文名：Bumadizone
• CAS号：3583-64-0
• 分子式：C₁₉H₂₂N₂O₃
• 分子量：326.39000
• 相关类别： 研究领域 炎症/免疫
• 发布时间：2018-08-21 18:06:36
• 更新时间：2026-07-16 19:38:49
• Bumadizone是一种非甾体抗炎药(NSAID),可以缓解疼痛[1]。

名称

• 中文名: 布马地宗
• 英文名: bumadizone
• 中文别名: 苯基丁氮酮杂质A(布马丁酮); 保泰松杂质A 标准品; 保泰松杂质A; 保泰松杂质1(保泰松杂质A)
• 英文别名: Butylpropanedioic acid mono(1,2-diphenylhydrazide); Bumadizon; IKCNUHJHLSPG-UHFFFAOYSA-N; (+-)-Buttersaeure-sec-butylamid; N-(2-Cboxycaproyl)hydrazobenzene; N-sec-butyl-butyramide; Phenylbutazone Impurity 1 (Phenylbutazone Impurity A); N-(2-Carboxy-hexanoyl)-hydrazobenzol; Butyramide,N-sec-butyl; N-(2-BUTYL)BUTANAMIDE; 2-(N,N'-diphenylhydrazinecbonyl)hexanoic acid; Butazone Impurity A; (2RS)-2-[(1,2-Diphenyldiazanyl)cb; N-(2-carboxycaproyl)hydrazobenzene; (+-)-Butylmalonsaeure-mono-<N.N'-diphenyl-hydrazid>; Butylmalonsaeure-N,N'-diphenylmonohydrazid; Butylmalonic acid 1-(N,N'-diphenyl hydrazide); Butylpropanedioic acid 1-(1,2-diphenyl hydrazide); Propanedioic acid,2-butyl-, 1-(1,2-diphenylhydrazide); Butylmalonic acid mono(1,2-diphenylhydrazide); Bumadizon (14C); Butanamide,N-(1-methylpropyl); (2RS)-2-[(1,2-Diphenyldiazanyl)carbonyl]hexanoic Acid; Phenylbutazone Impurity A (Bumadizone); 2-[(1,2-Diphenylhydrazino)carbonyl]hexanoic acid; N-s-Butyl-butyramide

物化性质

• 密度: 1.227g/cm3
• 沸点: 487.4ºC at 760mmHg
• 分子式: C₁₉H₂₂N₂O₃
• 分子量: 326.39000
• 闪点: 248.6ºC
• 精确质量: 326.16300
• PSA: 69.64000
• LogP: 4.01070
• 折射率: 1.628

生物活性

• 描述: Bumadizone是一种非甾体抗炎药(NSAID),可以缓解疼痛[1]。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 炎症/免疫
• 体外研究: 非甾体抗炎药(NSAIDs)广泛用于慢性炎症。
• 参考文献:

  [1]. Samia A Nour, et al. Bumadizone calcium dihydrate microspheres compressed tablets for colon targeting: formulation, optimization and in vivo evaluation in rabbits. Drug Deliv. 2015 May;22(3):286-97.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : OO0623000 CHEMICAL NAME : Malonic acid, butyl-, mono(1,2-diphenylhydrazide) CAS REGISTRY NUMBER : 3583-64-0 LAST UPDATED : 199712 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C19-H22-N2-O3 MOLECULAR WEIGHT : 326.43 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1350 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea REFERENCE : NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 67,337,1971 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 270 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea REFERENCE : NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 67,337,1971

安全

• 海关编码: 2928000090

合成路线

50-33-9 ~% 3583-64-0 16860-42-7 1227476-15-4

文献：Journal of Pharmaceutical Sciences, , vol. 73, # 12 p. 1709 - 1713

50-33-9 ~% 129-20-4 3583-64-0 16860-42-7 详细

文献：Journal of Pharmaceutical Sciences, , vol. 70, # 4 p. 460 - 461

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海关

海关编码	2928000090
中文概述	2928000090 其他肼（联氨）及胲（羟胺）的有机衍生物。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%