763114-04-1

• 常用中文名：奥拉帕尼杂质
• 常用英文名：2-Methyl-2-propanyl 4-{2-fluoro-5-[(4-oxo-3,4-dihydro-1-phthalazi nyl)methyl]benzoyl}-1-piperazinecarboxylate
• CAS号：763114-04-1
• 分子式：C₂₅H₂₇FN₄O₄
• 分子量：466.50500
• 发布时间：2016-04-19 06:26:41
• 更新时间：2024-01-11 10:00:31

名称

• 中文名: 奥拉帕尼杂质
• 英文名: 2-Methyl-2-propanyl 4-{2-fluoro-5-[(4-oxo-3,4-dihydro-1-phthalazi nyl)methyl]benzoyl}-1-piperazinecarboxylate
• 英文别名: tert-butyl 4-(2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoyl)piperazin-1-carboxylate; 5-(4-tert-butoxycarbonyl-1-piperazinyl)benzofuran-2-carboxamide; 4-[2-fluoro-5-(4-oxo-3,4-dihydro-phthalazin-1-ylmethyl)-benzoyl]-piperazine-1-carboxylic acid tert-butyl ester; tert-butyl 4-[2-fluoro-5-[(4-oxo-3H-phthalazin-1-yl)methyl]benzoyl]piperazine-1-carboxylate; Tert-butyl 4-(2-carbamoylbenzofuran-5-yl)piperazine-1-carboxylate; tert-butyl 4-[2-(aminocarbonyl)-1-benzofuran-5-yl]piperazine-1-carboxylate

物化性质

• 分子式: C₂₅H₂₇FN₄O₄
• 分子量: 466.50500
• 精确质量: 466.20200
• PSA: 95.86000
• LogP: 3.63400

合成路线

763114-26-7 57260-71-6 ~96% 763114-04-1

文献：Menear, Keith A.; Adcock, Claire; Boulter, Robert; Cockcroft, Xiao-Ling; Copsey, Louise; Cranston, Aaron; Dillon, Krystyna J.; Drzewiecki, Jan; Garman, Sheila; Gomez, Sylvie; Javaid, Hashim; Kerrigan, Frank; Knights, Charlotte; Lau, Alan; Loh Jr., Vincent M.; Matthews, Ian T. W.; Moore, Stephen; O'Connor, Mark J.; Smith, Graeme C. M.; Martin, Niall M. B. Journal of Medicinal Chemistry, 2008 , vol. 51, # 20 p. 6581 - 6591

119-67-5 ~% 763114-04-1

文献：SHANGHAI DE NOVO PHARMATECH CO LTD.; GAO, Daxin Patent: WO2012/71684 A1, 2012 ; WO 2012/071684 A1

218301-22-5 ~% 763114-04-1

文献：SHANGHAI DE NOVO PHARMATECH CO LTD.; GAO, Daxin Patent: WO2012/71684 A1, 2012 ; WO 2012/071684 A1

77771-02-9 ~% 763114-04-1

文献：SHANGHAI DE NOVO PHARMATECH CO LTD.; GAO, Daxin Patent: WO2012/71684 A1, 2012 ; WO 2012/071684 A1

61260-15-9 ~% 763114-04-1

文献：SHANGHAI DE NOVO PHARMATECH CO LTD.; GAO, Daxin Patent: WO2012/71684 A1, 2012 ; WO 2012/071684 A1

763114-25-6 ~% 763114-04-1

文献：SHANGHAI DE NOVO PHARMATECH CO LTD.; GAO, Daxin Patent: WO2012/71684 A1, 2012 ; WO 2012/071684 A1

1021298-68-9 ~% 763114-04-1

文献：SHANGHAI DE NOVO PHARMATECH CO LTD.; Gao, Daxin Patent: US2013/224107 A1, 2013 ;

上下游产品

上游产品  8
763114-26-7 57260-71-6 119-67-5 218301-22-5
77771-02-9 61260-15-9 763114-25-6 1021298-68-9
下游产品  0