1207456-00-5

• 常用中文名：(8R,9S)-5-氟-8-(4-氟苯基)-2,7,8,9-四氢-9-(1-甲基-1H-1,2,4-三唑-5-基)-3H-吡啶并[4,3,2-DE]酞嗪-3-酮
• 常用英文名：BMN-673 (8R,9S)
• CAS号：1207456-00-5
• 分子式：C₁₉H₁₄F₂N₆O
• 分子量：380.35100
• 相关类别： 研究领域 癌症
• 发布时间：2017-06-15 05:06:59
• 更新时间：2026-07-04 21:27:56
• Talazoparib 8R,9S (BMN-673 8R,9S) 是 Talazoparib 的 8R,9S 对映体,可抑制 PARP1 的活性,IC50 值为 144 nM,活性小于 Talazoparib。

名称

• 中文名: (8R,9S)-5-氟-8-(4-氟苯基)-2,7,8,9-四氢-9-(1-甲基-1H-1,2,4-三唑-5-基)-3H-吡啶并[4,3,2-DE]酞嗪-3-酮
• 英文名: (8R,9S)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H-pyrido[4,3 ,2-de] phthalazin-3(7H)-one
• 中文别名: (8R,9S)-5-氟-8-(4-氟苯基)-2,7,8,9-四氢-9-(1-甲基-1H-1,2,4-三唑-5-基)-3H-吡啶并[4,3,2-去]酞嗪-3-酮; STJ对映异构体; PP抑制剂(BMN-673 8R,9S); (8R,9S)-5-氟-8-(4-氟苯基)-9-(1-甲基-1H-1,2,4-三唑-5-基)-8,9-二氢-2H-吡啶并[4,3,2-DE]酞嗪-3(7H)-酮; 他拉唑帕利 (8R,9S); BMN-673 8R,9S异构体
• 英文别名: (8R,9S)-5-Fluoro-8-(4-fluorophenyl)-2,7,8,9-tetrahydro-9-(1-methyl-1H-1,2,4-triazol-5-yl)-3H-pyrido[4,3,2-de]phthalazin-3-one; (8R,9S)-5-fluoro-8-(4-fluorophenyl)-9-(1-Methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one; STJ enantiomers; BMN673 isomer; rac-Cbidopa Impurity I (3-Bromo rac-Cbidopa); LT-673 8R,9S; (8R,9S)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one; (8R,9S)-5-Fluoro-8-(4-fluorophenyl)-2,7,8,9-tetrahydro-9-(1-Methyl-1H-1,2,4-triazol-5-yl)-3H-pyrido[4,3,2-de]phthalazine-3-one; 3H-Pyrido[4,3,2-de]phthalazin-3-one, 5-fluoro-8-(4-fluorophenyl)-2,7,8,9-tetrahydro-9-(1-methyl-1H-1,2,4-triazol-5-yl)-, (8R,9S); BMN673 (8R,9S); (8R,9S)-BMN-673; BMN673 (8R; S-Talazopib; Talazopib racemic; BMN 673 (8R; Talazopib (8R; Talazopib 8R,9S; (8R,9S)-Talazopib; (8R,9S)-5-Fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H-pyrido[4; (8R,9S)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-2,7,8,9-tetrahydro-3H-pyrido[4,3,2-de]phthalazin-3-one; (8R,9S)-LT-673; CS-1223; TALAZOPIB (8R;9S);(8R;9S)-BMN-673;BMN673 (8R;9S);BMN 673 (8R;9S); 9S)-BMN-673; BMN 673 (8R,9S); BMN-673 8R,9S||BMN673 (8R,9S)|BMN 673 (8R,9S); 9S)-Talazopib; BMN-673 8R,9R isomer; BMN673 enantiomer

物化性质

• 分子式: C₁₉H₁₄F₂N₆O
• 分子量: 380.35100
• 精确质量: 380.12000
• PSA: 91.98000
• LogP: 1.89830
• 储存条件: -20°C，密闭，干燥

生物活性

• 描述: Talazoparib 8R,9S (BMN-673 8R,9S) 是 Talazoparib 的 8R,9S 对映体,可抑制 PARP1 的活性,IC50 值为 144 nM,活性小于 Talazoparib。
• 相关类别:
  研究领域 >> 癌症
• 靶点:

  PARP-1:144 nM (IC50)

• 参考文献:

  [1]. Wang B, et al. Discovery and Characterization of (8S,9R)-5-Fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-2,7,8,9-tetrahydro-3H-pyrido[4,3,2-de]phthalazin-3-one (BMN 673, Talazoparib), a Novel, Highly Potent, and Orally Efficacious Poly(ADP-

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