756-80-9

• 常用中文名：二硫代磷酸O,O'-二甲酯
• 常用英文名：Dimethylphosphorodithioate
• CAS号：756-80-9
• 分子式：C₂H₇O₂PS₂
• 分子量：158.18000
• 相关类别： 化学农药原药 杀虫剂中间体
• 发布时间：2018-06-05 08:00:00
• 更新时间：2024-01-05 06:25:29
• 【用途1】
  用作农药中间体，主要用于制备乐果、马拉硫磷等有机磷农药
  【用途2】
  O，O-二甲基二硫代磷酸酯简称甲基硫化物，是重要的有机磷农药中间体，可直接合成杀虫剂乐果、马拉硫磷、亚胺硫磷、稻丰散，除草剂莎稗磷，杀菌剂克菌壮等，还可通过氯化得到另一有机磷中间体O，O-二甲基硫代磷酰氯。

名称

• 中文名: 二甲基二硫代磷酸酯
• 英文名: dimethoxy-sulfanyl-sulfanylidene-λ5-phosphane
• 英文别名: O,O-dimethyl phosphorodithioic acid; dithiophosphorus acid O,O-dimethyl ester; Dimethylphosphorodithioate; EINECS 212-053-9; O,O-Dimethyl phosphorodithioate; Dimethyl phosphodithionate; dithiophosphoric acid-O.O-dimethyl ester; O,O-Dimethyldithiophosphate; O,O-dimethyldithiophosphoric acid; Dimethyldithiophosphoric acid; O,O-Dimethyl hydrogen dithiophosphate; Phosphorodithioic acid,O,O-dimethyl ester

物化性质

• 密度: 1.29
• 沸点: 65ºC
• 分子式: C₂H₇O₂PS₂
• 分子量: 158.18000
• 闪点: 71.2ºC
• 精确质量: 157.96300
• PSA: 99.16000
• LogP: 2.08410
• 外观性状: 液体;Colorless to Light yellow to Red clear liquid
• 折射率: 1.535
• 储存条件:

  塑料桶或铁桶密闭包装。贮存于阴凉通风干燥处。防热、防晒。按有毒物品规定贮运。

• 稳定性:

  本品有毒。对皮肤有刺激作用。生产场所应有良好的通风，设备应密闭，操作人员应穿戴防护用具。

• 更多:

  1.性状：无色液体，工业品为黑色液体，有恶臭气味。

  2. 相对密度（20℃）：1.288

  3. 折射率：1.535

  4.沸点（ºC，2.0kPa）：65

  5.溶解性：易溶于水和有机溶剂。能和碱及碱性物质发生反应，易被氧化，热稳定性差。

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : TE0525000 CHEMICAL NAME : Phosphorodithioic acid, O,O-dimethyl ester CAS REGISTRY NUMBER : 756-80-9 BEILSTEIN REFERENCE NO. : 0635993 LAST UPDATED : 199710 DATA ITEMS CITED : 9 MOLECULAR FORMULA : C2-H7-O2-P-S2 MOLECULAR WEIGHT : 158.18 WISWESSER LINE NOTATION : SHPS&O1&O1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : Standard Draize test ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - rabbit REFERENCE : 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,1175,1986 TYPE OF TEST : Standard Draize test ROUTE OF EXPOSURE : Administration into the eye SPECIES OBSERVED : Rodent - rabbit REFERENCE : 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,1175,1986 ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,1175,1986 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1550 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953- Volume(issue)/page/year: 28,599,1980 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Parenteral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 68500 ug/kg TOXIC EFFECTS : Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other esterases REFERENCE : AITDAQ Archiwum Immunologii i Terapii Doswiadczalnej. (Warsaw, Poland) V.1-9, 1953-61. For publisher information, see AITEAT. Volume(issue)/page/year: 6,333,1958 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - species unspecified DOSE/DURATION : 1400 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 39(4),86,1974 ** REPRODUCTIVE DATA ** TYPE OF TEST : TCLo - Lowest published toxic concentration ROUTE OF EXPOSURE : Inhalation DOSE : 161 mg/m3/6H SEX/DURATION : male 11 week(s) pre-mating TOXIC EFFECTS : Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females) REFERENCE : EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0385-0547

合成路线

1066-97-3 ~% 756-80-9

文献：WO2009/7998 A1, ; Page/Page column 8-10 ;

67-56-1 ~88% 756-80-9

文献：Robert, Didier; Curci, Michele; Mieloszynski, Jean-Luc; Paquer, Daniel Bulletin de la Societe Chimique de France, 1994 , vol. 131, p. 1015 - 1018

67-56-1 15857-57-5 ~% 756-80-9

文献：Gazzetta Chimica Italiana, , vol. 81, p. 596 - 608 P: MVol.C, 254, page 580 - 582 Journal of the American Chemical Society, , vol. 67, p. 1662 - 1664

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文献：Journal of Chemical Research - Part S, , # 12 p. 554 - 555

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文献：Journal of Agricultural and Food Chemistry, , vol. 54, # 20 p. 7753 - 7760

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文献：Justus Liebigs Annalen der Chemie, , vol. 119, p. 303

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文献：Journal of the Chemical Society, Chemical Communications, , # 9 p. 370 - 372

121-75-5 7732-18-5 67-64-1 ~% 7554-12-3 详细

文献：Recueil des Travaux Chimiques des Pays-Bas, , vol. 77, p. 973,976, 977

上下游产品

上游产品  9
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2953-29-9 67-63-0 121-75-5 7732-18-5
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30978-47-3 1066-97-3

制备

由五硫化二磷与甲醇进行酯化反应制得。将一定量的硫化物与五硫化二磷按质量比约0.7:1加入反应罐中，搅拌同时按一定摩尔比滴加甲醇，控制滴加温度在40~45℃，约2h加完，再于50~55℃继续搅拌反应约2h，冷却至35℃出料即得成品，收率75%以上。反应生成的硫化氢导入吸收塔内用碱液吸收。