950-37-8

950-37-8结构式

常用中文名：杀扑磷
常用英文名：Methidathion
CAS号：950-37-8
分子式：C₆H₁₁N₂O₄PS₃
分子量：302.331
相关类别：化学农药原药杀虫剂有机磷杀虫剂
发布时间：2018-06-14 19:59:09
更新时间：2024-01-02 20:05:11
是一种较理想的杀介壳虫药剂，可兼治螨类、粉虱、蚜虫，对梨术虱有特效

中文名	杀扑磷
英文名	methidathion
中文别名	S-2, 3-二氢-5- 甲氧基-2-氧代-1,3,4-硫二氮茂-3基甲基-0,0-二甲基二硫代磷酸酯 S-2,3-二氢-5-甲氧基-2-氧代-1,3,4-硫二氮茂-3-基甲基-O,O-二甲基二硫代磷酸酯速扑杀速扑蚧
英文别名	faat Phosphorodithioic Acid S-[(5-Methoxy-2-oxo-1,3,4-thiadiazol-3(2H)-yl)methyl]O,O-Dimethyl Ester Phosphorodithioic acid, S-[(5-methoxy-2-oxo-1,3,4-thiadiazol-3(2H)-yl)methyl] O,O-dimethyl ester S-((5-methoxy-2-oxo-1,3,4-thiadiazol-3(2H)-yl)methyl) O,O-dimethyl phosphorodithioate Dithiophosphoric Acid O,O'-Dimethyl-S-[(2-methoxy-1,3,4-thiadiazol-5(4H)-on-4-yl)methyl] Ester Geigy GS 13005 S-[(5-Methoxy-2-oxo-1,3,4-thiadiazol-3(2H)-yl)methyl] O,O-dimethyl phosphorodithioate sphat NC2964 oms844 O,O'-Dimethyl-S-[(2-methoxy-1,3,4-thiadiazole-5(4H)-one-4-yl)methyl] Dithiophosphate S-2,3-dihydro-5-methoxy-2-oxo-1,3,4-thiadiazol-3-ylmethyl O,O-dimethyl phosphorodithioate 3-dimethoxyphosphinothioylthiomethyl-5-methoxy-1,3,4-thiadiazol-2(3H)-one Methadithion dmtp Phosphorodithioic Acid O,O-Dimethyl Ester S-Ester with 4-(Mercaptomethyl)-2-methoxy-D2-1,3,4-thiadiazolin-5-one Somonil O,O-dimethyl S-(2,3-dihydro-5-methoxy-2-oxo-1,3,4-thiadiazol-3-ylmethyl)phosphorodithioate S-[(5-Methoxy-2-oxo-1,3,4-thiadiazol-3(2H)-yl)methyl]-O,O-dimethyldithiophosphat Dithiophosphoric acid O,O'-dimethyl-S-[(5-methoxy-1,3,4-thiadiazol-2(3H)-one-3-yl)methyl] ester hionate MFCD00055286 Methidathion T5NNVSJ B1SPS&O1&O1 EO1 EINECS 213-449-4

密度	1.6±0.1 g/cm3
沸点	347.7±52.0 °C at 760 mmHg
熔点	39-40°C
分子式	C₆H₁₁N₂O₄PS₃
分子量	302.331
闪点	164.1±30.7 °C
精确质量	301.961853
PSA	158.02000
LogP	2.03
外观性状	无色晶体
蒸汽压	0.0±0.8 mmHg at 25°C
折射率	1.652
储存条件	0-6°C密封储存
稳定性	常温常压下稳定
水溶解性	0.024 g/100 mL
分子结构	1、摩尔折射率：68.92 2、摩尔体积（cm³/mol）：188.5 3、等张比容（90.2K）：525.7 4、表面张力（dyne/cm）：60.4 5、极化率（10^-24cm³）：27.32
计算化学	1、疏水参数计算参考值（XlogP）：2.4 2、氢键供体数量：0 3、氢键受体数量：5 4、可旋转化学键数量：6 5、拓扑分子极性表面积（TPSA）：60.4 6、重原子数量：16 7、表面电荷：0 8、复杂度：343 9、同位素原子数量：0 10、确定原子立构中心数量：0 11、不确定原子立构中心数量：0 12、确定化学键立构中心数量：0 13、不确定化学键立构中心数量：0 14、共价键单元数量：1
更多	1. 性状：无色结晶固体 2. 密度（g/mL,20/4℃）：1.495 3. 相对蒸汽密度（g/mL,空气=1）：未确定 4. 熔点（ºC, 1.33Pa）：39-40℃ 5. 沸点（ºC,常压）：未确定 6. 沸点（ºC,5.2kPa）：未确定 7. 折射率：未确定 8. 闪点（ºC）：100°C 9. 比旋光度（º）：未确定 10. 自燃点或引燃温度（ºC）：未确定 11. 蒸气压（kPa,25ºC）：1.87×10^-4Pa 12. 饱和蒸气压（kPa,60ºC）：未确定 13. 燃烧热（KJ/mol）：未确定 14. 临界温度（ºC）：未确定 15. 临界压力（KPa）：未确定 16. 油水（辛醇/水）分配系数的对数值：未确定 17. 爆炸上限（%,V/V）：未确定 18. 爆炸下限（%,V/V）：未确定 19. 溶解性：易溶于丙酮、苯和甲醇。在中性和弱酸性介质中稳定，但在强酸和碱性介质中不稳定。

国标编号:	61125
ＣＡＳ:	950-37-8
中文名称:	杀扑磷
英文名称:	methidathion；Supracide；Vltracide；GS13005；NC2964
别名:	速扑杀；S-2，3-二氢-5-甲氧基-2-氧代-1，3，4-硫二氮茂-3基甲基-O，O-二甲基二硫供磷酸酯
分子式:	C₄H₇Br₂Cl₂O₄P
分子量:	381
熔点:	34～40℃
密度:	相对密度：1.495(20℃
蒸汽压:	0.133mPa (20℃)
溶解性:	20℃时水中为250ppm，丙酮690g/kg，乙醇260g/kg，环己
稳定性:	在中性介质中稳定，在碱中易分解。不易燃、不易爆炸，
外观与性状:	纯品为无色结晶
危险标记:	13(剧毒品)
用途:	本品为非内吸性杀虫剂，并具有一定杀螨活性，可防治多种汁食性害虫与叶食性害虫，特别是可防治介壳虫，基本上无药害

2.对环境的影响:
杀扑磷对人畜高毒。原药对雄大鼠急性经口毒性LD50为26mg/kg，雌大鼠43.8mg/kg；对大鼠急性经皮毒性LD50为1546mg/kg，兔为200mg/kg。对兔眼睛无刺激作用，对皮肤有轻度刺激。对鱼毒性大，虹鳟LC50(96小时)为0.01mg/L。
杀扑磷为有机磷杀虫剂对害虫和螨类有触杀和胃毒作用。

3.现场应急监测方法:

直接进水样气相色谱法

4.实验室监测方法:
气相色谱法(GB/T14552-93，水和土壤)

5.环境标准:
前西德(1978)食物中最高残留限值： 0.2～15mg/kg(特定农作物)；0.1mg/kg(一般农作物)

6.应急处理处置方法:
包装：可采用壁厚不小于1.2mm的铁桶，桶口严封不漏，每桶净重不应超过200kg，或以玻瓶或塑料瓶装后外包木箱，每箱净重不超过25kg。箱或桶外要贴上“剧毒品”标志。

消防：可用水、砂土、二氧化碳灭火。在灭火时应穿戴防护用品以防中毒。

急救：本品为高毒类有机磷农药，是强力羧基酯酶抑制剂。急性中毒，若皮肤污染应迅速脱去污染处衣物，用3～5%碳酸氢钠冲洗。溅入眼内，用2%碳酸氢钠或生理盐水冲洗10分钟以上，再滴1～2滴1%阿托品。口服中毒应尽早探咽导吐并洗胃，(可选2%碳酸氢钠或淡食盐水)，必要时肌肉注射可托品。

贮存与运输：本品应存放在干燥、阴凉的库房内，避免阳光照射，不可与氧化剂、易燃品与食用化工产品共存混运。搬运时应小心，避免损坏包装造成产品泄漏。工作人员应穿戴可靠的劳保用品。

毒理学数据:

急性毒性：小鼠口经LD50：25mg/kg；大鼠口经LD50：20mg/kg 急性毒性：大鼠吸入LD50：50mg/m3/4H

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TE2100000

CHEMICAL NAME :: Phosphorodithioic acid, O,O-dimethyl ester, S-ester with 4-(mercaptomethyl)-2-methoxy- delta(sup 2)-1,3,4-thiadiazolin-5-one

CAS REGISTRY NUMBER :: 950-37-8

LAST UPDATED :: 199706

DATA ITEMS CITED :: 20

MOLECULAR FORMULA :: C6-H11-N2-O4-P-S3

MOLECULAR WEIGHT :: 302.34

WISWESSER LINE NOTATION :: T5NNVSJ B1SPS&O1&O1 EO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: CIGET* Ciba-Geigy Toxicology Data/Indexes. (Ciba-Geigy Corp., 556 Morris Ave., Summit, NJ 07901) ** ACUTE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 93 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - miosis (pupillary constriction) Sense Organs and Special Senses (Eye) - lacrimation Behavioral - coma

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 20 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 50 mg/m3/4H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CIGET* Ciba-Geigy Toxicology Data/Indexes. (Ciba-Geigy Corp., 556 Morris Ave., Summit, NJ 07901)

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 25 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 25 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 63 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 196 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CIGET* Ciba-Geigy Toxicology Data/Indexes. (Ciba-Geigy Corp., 556 Morris Ave., Summit, NJ 07901)

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 25 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - chicken

DOSE/DURATION :: 80 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 25 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 25 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 225 mg/kg/9W-I

TOXIC EFFECTS :: Endocrine - changes in spleen weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 17155 mg/kg/1Y-I

TOXIC EFFECTS :: Liver - jaundice, cholestatic Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - multiple enzyme effects

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 40 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 88,307,1981 *** REVIEWS *** TOXICOLOGY REVIEW RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962- Volume(issue)/page/year: 46,1,1973 TOXICOLOGY REVIEW RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962- Volume(issue)/page/year: 63,1,1976 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X2166 No. of Facilities: 13 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 26 (estimated)

符号	GHS05, GHS06, GHS09
信号词	Danger
危害声明	H300 + H310 + H330-H318-H410
警示性声明	P260-P264-P273-P280-P284-P301 + P310
个人防护装备	dust mask type N95 (US);Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
危害码 (欧洲)	T+:Verytoxic;N:Dangerous for the environment;
风险声明 (欧洲)	R21;R28;R50/53
安全声明 (欧洲)	S22-S28-S36/37-S45-S60-S61
危险品运输编码	UN 2811
RTECS号	TE2100000
包装等级	II
危险类别	6.1(a)

50-00-0

17605-27-5

16001-68-6

950-37-8

文献：Helvetica chimica acta, , vol. 51, # 3 p. 518 - 526

50-00-0

17605-27-5

756-80-9

950-37-8

文献：Helvetica Chimica Acta, , vol. 57, p. 1658 - 1675

上游产品 4
50-00-0 17605-27-5 16001-68-6 756-80-9
下游产品 0

1.羰基肼的制备在反应锅内加入氢氧化钠、水、甲醇搅拌2h，降温至23～25℃滴加二硫代碳，保温2h,升温至（30±2）℃滴加水合肼并保温1.5h，冷却至0℃，离心得到灰白色的羰基肼晶体。
2.噻二唑酮的制备在反应锅内加入水、羰基肼，加入硫酸控制温度55～60℃，滴加氯甲酸三氯甲酯，约2h滴毕，（60±2）℃下保温2h，冷却至15℃离心，加冷水洗涤，得到淡黄色噻二唑酮晶体。
3.杀扑磷的合成在反应锅加75%硫酸、噻二唑酮、溶剂A、催化剂，升温至25℃下加入甲基硫代物，降温至20℃滴加甲醛，控温20～25℃滴毕升温至40℃保温2h，静置分去废酸层，加入水洗涤两次，70℃以下脱去1/2溶剂A和水分，冷却至0℃结晶，离心，得到白色杀扑磷原药，含量96%～98%，母液套回到杀扑磷合成中。含量96%～98%，收率42%。杀扑磷合成也可将5-甲氧基-2-氧代-1，3，4-硫二氮茂与甲醛和亚硫酰氯反应制得3-氯甲基-5-甲氧基-2-氧代-1，3，5-硫二氮茂，并将其与O，O-二甲基二硫代磷酸反应制得。
文献报道汽巴-嘉基公司、以色列亚姆公司对噻二唑酮合成采用光气法合成，杀扑磷纯度96%～97%。

950-37-8	19691-80-6
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