139756-22-2

• 常用中文名：3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo-(4-3-d)-pyrimidine-5;
• 常用英文名：4-Ethoxy-3-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)benzene-1-sulfonyl chloride
• CAS号：139756-22-2
• 分子式：C₁₇H₁₉ClN₄O₄S
• 分子量：410.875
• 发布时间：2018-11-29 00:29:30
• 更新时间：2026-07-25 17:57:40

名称

• 中文名: 3-(6,7-二氢-1-甲基-7-氧代-3-丙基-1H-吡唑O-(4-3-D)-嘧啶-5
• 英文名: 4-Ethoxy-3-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)benzene-1-sulfonyl chloride
• 中文别名: 西地那非磺酰氯杂质; 西地那非磺酰氯; 5-(5-氯磺基-2-乙氧基苯基)-1-甲基-3- 正丙基-1,6-二氢-7H-吡唑并[4,3-D]吡啶- 7-酮; 西地那非氯代磺酰化物; 西他那非碱; 1-甲基-3-丙基-5-(2-乙氧基-5-氯磺酰基)苯基-1,6-二氢-7H-吡唑并[4,3-D]嘧啶-7-酮; 枸橼酸西地那非杂质SLNM-03; 4-乙氧基-3-(1-甲基-7-氧代-3-丙基-6,7-二氢-1H-吡唑并[4,3-D]嘧啶-5-基)苯磺酰氯; 3-(6,7-二氢-1-甲基-7-氧代-3-丙基-1H-吡唑0-(-D)-喀啶-5; 3-(6,7-二氢-1-甲基-7-氧代-3-丙基-1H-吡唑O-(-D)-嘧啶-5; 3-(6,7-二氢-1-甲基-7-氧代-3-丙基-1H-吡唑O-(-D)-嘧啶-5 西地那非碱; 3-(6,7-二氢-1-甲基-7-氧代-3-丙基-1H-吡唑O-(-D)-嘧啶-5(西地那非杂质); 西地那非氯磺酰; 3-[1-甲基-3-丙基-7-氧代-6,7-二氢-1H-吡唑并[4,3-D]嘧啶-5-基]-4-乙氧基苯磺酰氯; 艾地那非杂质33; 5-(5-氯磺酰基-2-乙氧基苯基)-1-甲基-3-丙基-1,6-二氢-7h-吡唑并[4,3-d]嘧啶-7-酮; 西地那非杂质7; 氯磺酰西地那非; 艾地那非标准品004; 西地那非氯磺砜杂质; 5-(5-氯磺酰基-2-乙氧基苯基)-1-甲基-3-丙基-1,6-二氢-7H-吡唑并[4,3-D]嘧啶-7-酮; 西地那非磺酰氯中间体; 4-乙氧基-3-(1-甲基-7-氧代-3-丙基-6,7-二氢-1H-吡唑并[4,3-D]嘧啶-5-基)苯-1-磺酰氯; 3-(6,7-二氢-1-甲基-7-氧代-3-丙基-1H-吡唑O-(-D)-嘧啶-5 139-2; 4-乙氧基-3-(1-甲基-7-氧代-3-丙基-6,7-二氢-1H-293399吡唑并[4,3-D]嘧啶-5-基)苯-1-磺酰氯; 西地那非氯磺酸盐杂质
• 英文别名: 4-Ethoxy-3-(1-methyl-7-oxo-3-propyl-4,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)benzenesulfonyl chloride; 4-Ethoxy-3-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo-[4,3-d]pyrimidin-5-yl)benzene-1-sulfo; 5-(5-CHLORO SULFONYL-2-ETHOXY PHENYL)-1; Sildenafil Chlorosulfonyl (5-(5-Chlorosulfonyl-2-ethoxyphenyl)-1-methyl-3-propyl-1,6-dihydro-7H-pyra; 3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1 H-pyrazolo-(-d)-pyrimidine-5; 4-Ethoxy-3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)benzene-1-sulfonyl chloride; Methisosildenafil-004; 4-Ethoxy-3-(1-methy-oxo~3-propy,7-diliydro-lH-pyrazolo[4,3-d]pyrimidin-5-yl)benzene-1-suIfonyl cliloride; Methisosildenafil Impurity 33; 3-(4,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxy-benzenesulfonyl Chloride; Sildenafil impurity 33/Sildenafil Chlorosulfonyl/Sildenafil Chlorosulfone Impurity/5-(5-Chlorosulfonyl-2-ethoxyphenyl)-1-methyl-3-propyl-1,6-dihydro-7H-pyrazole[4,3-d]pyrimidine-7-one; Benzenesulfonyl chloride, 3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxy; 5-(5-Chlorosulfonyl-2-ethoxyphenyl)-1-methyl-3-propyl-1,6-di; Sildenafil intermediate; Sildenafil Chlorosulfonyl IMpurity; Sildenafil Impurity 7; 5-(5-Chlorosulfonyl-2-ethoxyphenyl)-1-methyl-3-propyl-1,6-dihydro-7H-pyrazole[4,3-d]pyrimidine-7-one; Sildenafil Chlorosulfone IMpurity; Sildenafil Chlorosulfonyl (5-(5-Chlorosulfonyl-2-ethoxyphenyl)-1-methyl-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one); 4-Ethoxy-3-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo-[4,3-d]pyrimidin-5-yl)benzene-1-su; 4-Ethoxy-3-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)benzenesulfonyl chloride; 5-(5-Chlorosulfonyl-2-ethoxyphenyl)-1-methyl-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one; Sildenafil Chlorosulfone; 4-ethoxy-3-(1-methyl-7-oxo-3-propyl-6,7-dihydro; 4-Ethoxy-3-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl); Demethylpiperazinyl sildenafil sulfonyl chloride; 5-(5-CHLOROSULFONYL-2-ETHOXY PHENYL)-1-METHYL-3-N-PROPYL-1; 4-Ethoxy-3-(1-Methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyriMidin-5-yl)benzene-1-sulfonyl chloride; Sildenafil Chlorosulfone Impurity / Sildenafil Chlorosulfone / Sildenafil Chlorosulfonyl Impurity; 4-Ethoxy-3-(1-methyl-7-oxo-3-propyl-4,7-dihydro-1H-pyrazolo4,3-dpyrimidin-5-yl)benzene-1-sulfonyl chloride; 5-(5-CHLORO SULFONYL-2-ETHOXY PHENYL)-1- METHYL-3-PROPYL-1 6-DIHYDRO-7H-PYRAZOL O-(4 3-D)PYRIMIDINE-7-ONE; 4-ethoxy-3-(1-methyl-7-oxo-3-propyl-4H-pyrazolo[4,3-d]pyrimidin-5-yl)benzenesulfonyl chloride; Sildenafil chlorosulfonyl; 5-(5-CHLORO SULFONYL-2-ETHOXYPHENYL)-1-METHYL-3-N-PROPYL-1,6-DIHYDRO-7H-PYRAZOLO-[4,3,D]-PYRIMIDINE-7-ONE

物化性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 621.4±65.0 °C at 760 mmHg
• 熔点: 180-182ºC
• 分子式: C₁₇H₁₉ClN₄O₄S
• 分子量: 410.875
• 闪点: 329.6±34.3 °C
• 精确质量: 410.081543
• PSA: 115.32000
• LogP: 2.76
• 外观性状: 白色至浅黄色固体
• 蒸汽压: 0.0±1.8 mmHg at 25°C
• 折射率: 1.663
• 储存条件: 2-8°C， 惰性气体

安全

• 危害码 (欧洲): C
• 危险品运输编码: 3261.0
• 海关编码: 2933990090

合成路线

139756-21-1 ~97% 139756-22-2

文献：Flores Toque, Haroldo A.; Priviero, Fernanda B. M.; Teixeira, Cleber E.; Perissutti, Elisa; Fiorino, Ferdinando; Severino, Beatrice; Frecentese, Francesco; Lorenzetti, Raquel; Baracat, Juliana S.; Santagada, Vincenzo; Caliendo, Giuseppe; Antunes, Edson; De Nucci, Gilberto Journal of Medicinal Chemistry, 2008 , vol. 51, # 9 p. 2807 - 2815

上下游产品

上游产品  1
139756-21-1
下游产品  3
642928-07-2 139755-85-4 139755-83-2

海关

海关编码	2933990090
中文概述	2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%