139756-21-1

• 常用中文名：5-(2-乙氧苯基)-1-甲基-3-丙基-1,6-二氢-7H-吡唑并[4,3-D]嘧啶-7-酮
• 常用英文名：5-(2-Ethoxyphenyl)-1-methyl-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]-7-pyrimidinone
• CAS号：139756-21-1
• 分子式：C₁₇H₂₀N₄O₂
• 分子量：312.366
• 相关类别： 信号通路 代谢酶/蛋白酶 磷酸二酯酶(PDE)
• 发布时间：2018-12-28 06:54:06
• 更新时间：2026-07-16 14:33:10
• PDE5-IN-7(化合物8)是一种选择性磷酸二酯酶5(PDE5)抑制剂,其IC50值为5nM,而PDE1的IC50为300nM[1]。

名称

• 中文名: 5-(2-乙氧苯基)-1-甲基-3-丙基-1,6-二氢-7H-吡唑并[4,3-d]嘧啶-7-酮
• 英文名: 5-(2-Ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
• 中文别名: 5-(2-乙氧苯基)-1-甲基-3-丙基-1,6-二氢-7H-吡唑并[4,3-D]喀啶-7-酮; 脱硫伐地那非; 5-(2-乙氧苯基)-1-甲基-3-丙基-1,6-二氢-7H-吡唑并[4,3-D]嘧啶-7-酮/西地那非嘧啶酮; 5-(2-乙氧苯基)-1-甲基-3-丙基-1,6-二氢-7H-吡唑并[4,3-D]-7-嘧啶酮; 5-(2-乙氧苯基)-1-甲基-3-正丙基-1,6-二氢-7H-吡唑并[4,3-D]-7-嘧啶酮; 5-(2-乙氧苯基)-1-甲基-3-丙基-1,6-二氢-7H-吡唑并1[4,3-D]嘧啶-7-酮; 西地那非嘌呤; 嘧啶酮(精致嘌呤); 枸橼酸西地那非杂质L; 枸橼酸西地那非杂质PZMD; 5-(2-乙氧苯基)-1-甲基-3-丙基-1,6-二氢-7H-吡唑并[4,3-D]嘧啶-7-酮(139-1); 5-(2-乙氧基苯基)-1-甲基-3-n-丙基-1,6-二氢-7H-吡唑并[4,3-d]-7-嘧啶酮; 5-(2-乙氧苯基)-1-甲基-3-正丙基-1,6-二氫-7H-吡唑并[4,3-D]-7-嘧啶酮; 枸橼酸西地那非杂质25; 5-(2-乙氧基苯基)-1-甲基-3-N-丙基-1,6-二氢-7H-吡唑并[4,3-D]-7-嘧啶酮; 5-(2-乙氧苯基)-1-甲基-3-丙基-1,6-二氢-7H-吡唑并[4,3-D]嘧啶-7-酮(西地那非杂质); 西地那非内酰胺杂质; 西地那非-内酰胺杂质(西地那非杂质97); 脱硫伐地那非,5-(2-乙氧苯基)-1-甲基-3-丙基-1,6-二氢-7H-吡唑并[4,3-D]-7-嘧啶酮
• 英文别名: 1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H); 5-(2-ETHOXY PHENYL)-1-METHYL-3-N-PROPYL- 1 6-DIHYDRO-7H-PYRAZOLO-(4 3D)PYRIMIDINE; 5-(2-ethoxyphenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(4H)-one; DPX 84; 5-(2-ethoxyphenyl)-1-methyl-3-propyl-1H,4H,7H-pyrazolo[4,3-d]pyrimidin-7-one; 5-(2-Ethoxyphenyl)-1-methyl-3-propyl-1,6-dihydro-7H-pyrazole[4,3-d]pyrimidine-7-one; 5-(2-ETHOXYPHENYL)-1-ME-3-N-PROPYL-1,6-DIHYDRO-7H-PYRAZOLO(4,3D)-7-PYRIMIDIN; 5-(2-ethoxyphenyl)-1-methyl-3-propyl-1H,6H,7H-pyrazolo[4,3-d]pyrimidin-7-one; 5-(2-ethoxyphenyl)-1-Methyl-3-propyl-6H-pyrazolo[4,3-d]pyriMidin-7-one; 5-(2-Ethoxypheny1)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one; UK 088800, 10 mM in DMSO; 5-(2-Ethoxyphenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one; 5-(2-ETHOXYPHENYL)-1-METHYL-3-N-PROPYL-1; 5-(2-ETHOXYPHENYL)-1-METHYL-3-N-PROPYL-1,6-DIHYDRO-7H-PYRAZOLO[4,3-D]-7-PYRIMIDINONE; 5-(2-ethoxyphenyl)-1-methyl-3-propyl; 5-(2-Ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]-7-pyrimidinone; 5-(2-Ethoxyphenyl)-1-methyl-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one; 5-(2-Ethoxyphenyl)-1-methyl-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]-7-pyrimidinone CAS NO.139-1; 5-(2-Ethoxyphenyl)-1-Methyl-3-N-Propyl-1,6-Dihydro-7H-Pyrazo; 5-(2-Ethoxyphenyl)-1-Methyl-3-propyl-1H-pyrazolo[4,3-d]pyriMidin-7(6H)-one; 5-(2-Ethoxy Phenyl)-1,6-Dihydro-1-MethyI-3-Propyl-7H-Pyrazolo-[4,3-d] Pyrimidin-7-one; 5-(2-Ethoxyphenyl)-1-methyl-3-propyl-1,4-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one; Sildenafil impurity E(Sildenafil Lactam Impurity); Tianfu Chem 5-(2-ETHOXYPHENYL)-1-METHYL-3-N-PROPYL-1,6-DIHYDRO-7H-PYRAZOLO[4,3-D]-7-PYRIMIDINONE; Sildenafil LactaM IMpurity; 5-(2-Ethoxyphenyl); 7H-PYRAZOLO[4,3-D]PYRIMIDIN-7-ONE,5-(2-ETHOXYPHENYL)-1,4-DIHYDRO-1-METHYL-3-PROPYL; 5-(2-ethoxyphenyl)-1-methyl-3-propyl-1,4-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one; 5-(2-ETHOXYPHENYL)-1-METHYL-3-N-PROPYL-1,6-DIHYDRO-7H-PYRAZOLO[4,3-D]PYRIMIDIN-7-ONE; 5-(2-ethoxyphenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7-ol; Sildenafil citrate impurity L; 5-(2-ethoxyphenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one (EMP); PDE5-IN-7; 7H-Pyrazolo[4,3-d]pyrimidin-7-one, 5-(2-ethoxyphenyl)-1,6-dihydro-1-methyl-3-propyl; 5-(2-ethoxyphenyl)-1-methyl-3-propyl-4H-pyrazolo[4,3-d]pyrimidin-7-one; 5-(2-ethoxyphenyl)-1-methyl-3-propyl-1,6-dihydro-7h-pyrazolo[4,3-d]-7-pyrimidinone; 5-(2-Ethoxyphenyl)-1-methyl-prop; Sildenafil pyrimidinone; 5-(2-Ethoxyphenyl)-l-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolol- 4,3-dipyrimidin-7-one

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 504ºC at 760 mmHg
• 熔点: 141-145ºC(lit.)
• 分子式: C₁₇H₂₀N₄O₂
• 分子量: 312.366
• 闪点: 258.6ºC
• 精确质量: 312.158630
• PSA: 72.80000
• LogP: 2.38
• 外观性状: 固体;White to Light yellow to Light orange powder to crystal
• 蒸汽压: 2.75E-10mmHg at 25°C
• 折射率: 1.632
• 储存条件: 室温，干燥

生物活性

• 描述: PDE5-IN-7(化合物8)是一种选择性磷酸二酯酶5(PDE5)抑制剂,其IC50值为5nM,而PDE1的IC50为300nM[1]。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> 磷酸二酯酶(PDE)
  研究领域 >> 其他
• 靶点:

  PDE5:5 nM (IC50)

  PDE1:300 nM (IC50)

• 体外研究: PDE5-IN-7(化合物15,Desild)可以从西地那非(HY-15025)衍生物中检测和分离[2]。

安全

• 符号: GHS07
• 信号词: Warning
• 危害声明: H315-H319-H335
• 警示性声明: P261-P305 + P351 + P338
• 个人防护装备: dust mask type N95 (US);Eyeshields;Gloves
• 危害码 (欧洲): Xi: Irritant;
• 风险声明 (欧洲): R36/37/38
• 安全声明 (欧洲): S26-S36
• 危险品运输编码: NONH for all modes of transport
• WGK德国: 3
• 海关编码: 2933990090

合成路线

上下游产品

上游产品  10
139756-03-9 613-69-4 139756-02-8 42926-52-3
139756-01-7 36983-31-0 139755-99-0 133261-07-1
139756-00-6 134-11-2
下游产品  6
371959-09-0 479074-06-1 1058653-74-9 139755-85-4
139755-83-2 139756-22-2

海关

海关编码	2933990090
中文概述	2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%