86347-15-1

• 常用中文名：盐酸美托咪啶
• 常用英文名：Medetomidine HCl
• CAS号：86347-15-1
• 分子式：C₁₃H₁₇ClN₂
• 分子量：236.740
• 相关类别： 生物化工 抑制剂 神经信号通路(Neuronal Signaling) Adrenergic Receptor 激动剂
• 发布时间：2018-07-21 16:26:10
• 更新时间：2026-06-30 22:33:23
• Medetomidine(Domtor)盐酸盐是α2肾上腺素受体激动剂,对α2和α1肾上腺素受体的Ki分别为1.08 nM和1750 nM。

名称

• 中文名: 盐酸美托咪啶
• 英文名: medetomidine hydrochloride
• 中文别名: (R)-4-[1-(2,3-二甲基苯基)乙基]-1H-咪唑盐酸盐; 3-二甲基苯基)乙基]-1H-咪唑盐酸盐; 盐酸美托咪啶杂质; 盐酸美托咪定 Medetomidine hydrochloride; 盐酸美托嘧啶Medetomidine Hydrochloride; 环丙氨嗪; 盐酸美扥咪啶; 盐酸美托咪啶/盐酸美托咪定; 盐酸美托咪定; 盐酸咪托咪定; 盐酸美托嘧啶; MEDETOMIDINE HYDROCHLORIDE,ALPHA2 ADRENOCTOR激动剂(AQUEOUS SOLUTION); MEDETOMIDINE HYDROCHLORIDE,ALPHA2 ADRENOCTOR激动剂; 2,3-二甲基苯基; 5-[1-(2,3-二甲基苯基)乙基]-1H-咪唑盐酸盐; Medetomidine hydrochloride试剂; 美托咪定盐酸盐; 4-(1-(2,3-二甲基苯基)乙基)-1H咪唑盐酸盐
• 英文别名: 4-[(a-Methyl)-2,3-dimethylbenzyl]imidazole Monohydrochloride; edetomidine; Medetomidine Hydrochloride Impurities; 3-Dimethylphenyl)ethyl]-1H-imidazole hydrochloride; Ethyl Acetate Impurity 85; UNII:BH210P244U; SIMS1031 Medetomidine HCl --86-1; 2-amino-5-(2-ethoxyanilino)-4-hydroxy-1H-pyrimidin-6-one; 1H-Imidazole, 4-[1-(2,3-dimethylphenyl)ethyl]-, hydrochloride (1:1); medeomidine hcl; Medetomidine HCl (MPV-785); 1H-Imidazole, 5-[1-(2,3-dimethylphenyl)ethyl]-, hydrochloride (1:1); Metoclopramide (metoclopramide); Medetomidine HC; Medetomidine hydrochloride,anxiolysis,inhibit,sedation,Medetomidine,α2-adrenoctor,MPV-785,peripheral nervous system,analgesia,MPV 785,central nervous system,Inhibitor,muscle relaxation,Beta Rector,Adrenergic Rector; MEDETOMIDINE HYDROCHLORIDE; Medetomidine Hcl Medetomidine Hydrochloride; (R)-4-[1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole hydrochloride //BP; 4-[1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole hydrochloride (1:1); Medetomidine HCI; 5-[1-(2,3-dimethylphenyl)ethyl]-1H-imidazole monohydrochloride; Medetomidine HCl Powder; Medetomidine hydrochloride (R)-4-[1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole hydrochloride; medetomidine HCl; (R)-4-[1-(2; Medetomidine hydrochloride, 10 mM in DMSO; Medetomidine hydrochloride, alpha2 adrenoctor agonist; 4-[1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole Monohydrochloride; (r)-4-[1-(2,3-dimethylphenyl)ethyl]-1h-imidazole hydrochloride; Metetomidine HCl; 5-[1-(2,3-diMethylphenyl)ethyl]-1H-IMidazole hydrochloride; (±)-4-(a,2,3-Trimethylbenzyl)imidazole Monohydrochloride; Medetomidine hydrochloride, alpha2 adrenoctor agonist (aqueous solution); Medetomidine (hydrochloride)

物化性质

• 沸点: 381.9ºC at 760 mmHg
• 熔点: 164-166°C
• 分子式: C₁₃H₁₇ClN₂
• 分子量: 236.740
• 闪点: 191.3ºC
• 精确质量: 236.108032
• PSA: 28.68000
• LogP: 3.98030
• 外观性状: 白色或灰白色结晶粉末
• 储存条件: Refrigerator

生物活性

• 描述: Medetomidine(Domtor)盐酸盐是α2肾上腺素受体激动剂,对α2和α1肾上腺素受体的Ki分别为1.08 nM和1750 nM。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 肾上腺素能受体
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Davies, M.F., et al., Activation of alpha2 adrenergic receptors suppresses fear conditioning: expression of c-Fos and phosphorylated CREB in mouse amygdala. Neuropsychopharmacology, 2004. 29(2): p. 229-39.

  [2]. Ozdogan, U.K., et al., The involvement of alpha 2A-adrenoceptors in morphine analgesia, tolerance and withdrawal in mice. Eur J Pharmacol, 2004. 497(2): p. 161-71.

  [3]. Menon, D.V., et al., Central sympatholysis as a novel countermeasure for cocaine-induced sympathetic activation and vasoconstriction in humans. J Am Coll Cardiol, 2007. 50(7): p. 626-33.

安全

• 海关编码: 2942000000

合成路线

1021949-47-2 ~89% 86347-15-1

文献："Joint Stock Company Grindeks" Patent: EP1918282 A1, 2008 ; Location in patent: Page/Page column 6 ;

86347-14-0 ~% 86347-15-1

文献：WO2009/53709 A1, ; Page/Page column 13; 15-16 ;

576-23-8 ~% 86347-15-1

文献：WO2013/14428 A1, ;

1421259-20-2 ~% 86347-15-1

文献：WO2013/14428 A1, ;

1421259-22-4 ~% 86347-15-1

文献：WO2013/14428 A1, ;

上下游产品

上游产品  3
1021949-47-2 86347-14-0 576-23-8
下游产品  1
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海关

海关编码	2942000000