134031-86-0

• 常用中文名：2'-OMe-U亚磷酰胺单体
• 常用英文名：2'-OMe-U Phosphoramidite
• CAS号：134031-86-0
• 分子式：C₄₀H₄₉N₄O₉P
• 分子量：760.81
• 相关类别： 信号通路 细胞周期/DNA损伤 核苷抗代谢药/类似物
• 发布时间：2018-12-09 20:31:41
• 更新时间：2026-07-23 07:23:41
• 3'-O-DDMTr-胸苷5'-CE磷脒是嘌呤核苷类似物。嘌呤核苷类似物具有广泛的抗肿瘤活性,靶向惰性淋巴系统恶性肿瘤。这一过程中的抗癌机制依赖于抑制DNA合成、诱导细胞凋亡等[1]。

名称

• 中文名: 5'-O-[(二异丙基氨基)-(2-氰基乙氧基)氧磷基]-3'-O-(4,4'-二甲氧基三苯甲基)胸苷
• 英文名: 3-[[(2R,3S,5R)-3-[bis(4-methoxyphenyl)-phenylmethoxy]-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-[di(propan-2-yl)amino]phosphoryl]oxypropanenitrile
• 中文别名: 2’-OME-U 亚磷酰胺单体; 3'-O-DMT-脱氧胸苷-5'-氰乙氧基 REVERSE亚磷酰胺; idT亚磷酰胺; 2'-OME-U 亚磷酰胺单体; 2'-OME-RU-CE亚磷酰胺单体; 3'-DMT-5'-CE脱氧胸苷亚磷酰胺; 2'-OME-U亚磷酰胺; DMT-dT单体; idT亚磷酰胺单体; 3'-O-[二(4-甲氧基苯基)苯基甲基]胸苷 5'-[2-氰基乙基二异丙基氨基亚磷酸酯]
• 英文别名: idT CE Phosphoramidite; Thymidine, 3'-O-[bis(4-methoxyphenyl)phenylmethyl]-, 5'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; idT phosphoramidite; 5'-O-[(DiisopropylaMino)-(2-cyanoethoxy)phosphinyl]-3'-O-(4,4'-diMethoxytrityl)thyMidine; 5'-O-[(Diisopropylamino)-(2-cyanoethoxy)phosphinyl]-3'-O-(4,4'-dimethoxytrityl)thymidine; 3’-O-DMTr-thymidine 5’-CE phosphoramidite; 3-DMT Thymidine 5-CED phosphoramidite; 2'-OMe-UPhosphoramidite; 2'-O-Methyl-5'-O-DMT-Uridine-3'-CE-Phosphoramidite; 3’-O-DMTr-thymidine 5’-CE phosphoramidite; 2'-OMe-rU-CE Phosphoramidite; 5'-O-[(N,N-DIISOPROPYLAMINO)-(2-CYANOETHOXY)PHOSPHINYL]-3'-O-(4,4'-DIMETHOXYTRITYL)-THYMIDINE; 3'-O-DMT-thymidine 5'-CE phosphoramidite; Rev T-5’-amidite; DMT-dT-CE Reverse Phosphoramidite; 3'-O-(4,4'-Dimethoxytrityl)-thymidine-5'-cyanoethyl-Phosphoramidite; 3'-Dimethoxytrityl-2'-deoxyThymidine,5'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; DMT-dT-CE-Inverted-Phosphoramidite; 5′-O-[(Diisopropylamino)-(2-cyanoethoxy)phosphinyl]-3′-O-(4,4′-dimethoxytrityl)thymidine; 3'-O-DMTr-thymidine 5'-CE phosphoramidite; 3'-O-[Bis(4-methoxyphenyl)phenylmethyl]thymidine 5'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; DMT-dT-5'-CE Reverse Phosphoramidite

物化性质

• 分子式: C₄₀H₄₉N₄O₉P
• 分子量: 760.81
• 精确质量: 744.32900
• PSA: 150.86000
• LogP: 6.81958
• 储存条件: 室温

生物活性

• 描述: 3'-O-DDMTr-胸苷5'-CE磷脒是嘌呤核苷类似物。嘌呤核苷类似物具有广泛的抗肿瘤活性,靶向惰性淋巴系统恶性肿瘤。这一过程中的抗癌机制依赖于抑制DNA合成、诱导细胞凋亡等[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 细胞周期/DNA损伤 >> 核苷抗代谢药/类似物
• 参考文献:

  [1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

合成路线

102691-36-1 76054-81-4 ~73% 134031-86-0

文献：Wagner, Thomas; Pfleiderer, Wolfgang Helvetica Chimica Acta, 2000 , vol. 83, # 8 p. 2023 - 2035

40615-36-9 ~% 134031-86-0

文献：Helvetica Chimica Acta, , vol. 83, # 8 p. 2023 - 2035

123533-02-8 ~% 134031-86-0

文献：Helvetica Chimica Acta, , vol. 83, # 8 p. 2023 - 2035

112141-36-3 ~% 134031-86-0

文献：Helvetica Chimica Acta, , vol. 83, # 8 p. 2023 - 2035

199792-87-5 ~% 134031-86-0

文献：Helvetica Chimica Acta, , vol. 83, # 8 p. 2023 - 2035

199792-94-4 ~% 134031-86-0

文献：Helvetica Chimica Acta, , vol. 83, # 8 p. 2023 - 2035

50-89-5 ~% 134031-86-0

文献：Helvetica Chimica Acta, , vol. 83, # 8 p. 2023 - 2035

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