134031-86-0

134031-86-0 structure

Name: 2'-OMe-U Phosphoramidite
Chemical Name: 3-[[(2R,3S,5R)-3-[bis(4-methoxyphenyl)-phenylmethoxy]-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-[di(propan-2-yl)amino]phosphoryl]oxypropanenitrile
CAS Number: 134031-86-0
Molecular Formula: C₄₀H₄₉N₄O₉P
Molecular Weight: 760.81
Catalog: Signaling Pathways Cell Cycle/DNA Damage Nucleoside Antimetabolite/Analog
Create Date: 2018-12-09 20:31:41
Modify Date: 2024-01-03 19:05:00
3’-O-DMTr-thymidine 5’-CE phosphoramidite is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

Name	3-[[(2R,3S,5R)-3-[bis(4-methoxyphenyl)-phenylmethoxy]-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-[di(propan-2-yl)amino]phosphoryl]oxypropanenitrile
Synonyms	5′-O-[(Diisopropylamino)-(2-cyanoethoxy)phosphinyl]-3′-O-(4,4′-dimethoxytrityl)thymidine 2'-OMe-UPhosphoramidite 5'-O-[(Diisopropylamino)-(2-cyanoethoxy)phosphinyl]-3'-O-(4,4'-dimethoxytrityl)thymidine 2'-OMe-U Phosphoramidite DMT-dT-CE Reverse Phosphoramidite

Description	3’-O-DMTr-thymidine 5’-CE phosphoramidite is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog
References	[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

102691-36-1

76054-81-4

~73%

134031-86-0

Literature: Wagner, Thomas; Pfleiderer, Wolfgang Helvetica Chimica Acta, 2000 , vol. 83, # 8 p. 2023 - 2035