156-86-5

• 常用中文名：高精氨酸
• 常用英文名：Homoarginine
• CAS号：156-86-5
• 分子式：C₇H₁₆N₄O₂
• 分子量：188.227
• 相关类别： 生物化工 常见氨基酸及蛋白质类药
• 发布时间：2018-08-01 10:05:36
• 更新时间：2024-01-02 13:08:45
• H-HoArg-OH,精氨酸的同系物,是人骨和肝脏碱性磷酸酶 (alkaline phosphatase) 的强效抑制剂。

名称

• 中文名: 高精氨酸
• 英文名: L-homoarginine
• 中文别名: 類鳥氨酸; L-高精氨酸
• 英文别名: (S)-2-Amino-6-guanidinohexanoic acid; N6-(Aminoiminomethyl)-L-lysine; H-HOARG-OH; Homoarginine; MFCD00237108; L-Homoarginine; L-Lysine, N6- (aminoiminomethyl)-; N-Carbamimidoyl-L-lysine; N6-amidino-L-Lysine; N6-Carbamimidoyl-L-lysin; H-HAR-OH; L-Lysine, N-(aminoiminomethyl)-; H-HOMOARGININE; H-HOMOARG-OH; Homo-L-arginine; N6-carbamimidoyl-L-lysine; l-lysin

物化性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 376.3±52.0 °C at 760 mmHg
• 分子式: C₇H₁₆N₄O₂
• 分子量: 188.227
• 闪点: 181.4±30.7 °C
• 精确质量: 188.127319
• PSA: 125.22000
• LogP: -1.86
• 外观性状: 白色结晶粉末
• 蒸汽压: 0.0±1.8 mmHg at 25°C
• 折射率: 1.587
• 储存条件: Store at RT.
• 分子结构:

  1、 摩尔折射率：45.30

  2、 摩尔体积（cm³/mol）：134.8

  3、 等张比容（90.2K）：377.1

  4、 表面张力（dyne/cm）：61.1

  5、 极化率（10-24cm3）：17.96

生物活性

• 描述: H-HoArg-OH,精氨酸的同系物,是人骨和肝脏碱性磷酸酶 (alkaline phosphatase) 的强效抑制剂。
• 相关类别:
  研究领域 >> 代谢疾病
  天然产物 >> 其他
• 靶点:

  Human Endogenous Metabolite

  Alkaline phosphatase

• 体外研究: 发现H-HoArg-OH(L-高精氨酸)是精氨酸的同源物,是人体骨骼和肝脏碱性磷酸酶的强抑制剂,与H-HoArg-OH不同,它对肠道和胎盘碱性磷酸酶几乎没有影响。抑制肠道和胎盘碱性磷酸酶,但不抑制肝脏和骨骼酶。提到的这四种组织是血清碱性磷酸酶的主要贡献者[1]。还表明低水平的内源氨基酸H-HoArg-OH与心血管疾病有关[2]。
• 参考文献:

  [1]. Fishman W, et al. L-homoarginine; an inhibitor of serum "bone and liver" alkaline phosphatase. Clin Chim Acta. 1970 Aug;29(2):339-41.

  [2]. Atzler D, et al. L-homoarginine and cardiovascular disease. Curr Opin Clin Nutr Metab Care. 2015 Jan;18(1):83-8.

MSDS

Material Safety Data Sheet Section1. Identification of the substance Product Name: Homoarginine Synonyms: Section2. Hazards identification Harmful by inhalation, in contact with skin, and if swallowed. Section3. Composition/information on ingredients. Ingredient name:Homoarginine CAS number:156-86-5 Section4. First aid measures Skin contact:Immediately wash skin with copious amounts of water for at least 15 minutes while removing contaminated clothing and shoes. If irritation persists, seek medical attention. Eye contact:Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical attention. Inhalation:Remove to fresh air. In severe cases or if symptoms persist, seek medical attention. Ingestion:Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention. Section5. Fire fighting measures In the event of a fire involving this material, alone or in combination with other materials, use dry powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus should be worn. Section6. Accidental release measures Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national standards. Respiratory precaution:Wear approved mask/respirator Hand precaution:Wear suitable gloves/gauntlets Skin protection:Wear suitable protective clothing Eye protection:Wear suitable eye protection Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container for disposal. See section 12. Environmental precautions: Do not allow material to enter drains or water courses. Section7. Handling and storage Handling:This product should be handled only by, or under the close supervision of, those properly qualified in the handling and use of potentially hazardous chemicals, who should take into account the fire, health and chemical hazard data given on this sheet. Store in closed vessels. Storage: Section8. Exposure Controls / Personal protection Engineering Controls: Use only in a chemical fume hood. Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles. General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse. Section9. Physical and chemical properties Appearance:Not specified Boiling point:No data No data Melting point: Flash point:No data Density:No data Molecular formula:C7H16N4O2 Molecular weight:188.2 Section10. Stability and reactivity Conditions to avoid: Heat, flames and sparks. Materials to avoid: Oxidizing agents. Possible hazardous combustion products: Carbon monoxide, nitrogen oxides. Section11. Toxicological information No data. Section12. Ecological information No data. Section13. Disposal consideration Arrange disposal as special waste, by licensed disposal company, in consultation with local waste disposal authority, in accordance with national and regional regulations. Section14. Transportation information Non-harzardous for air and ground transportation. Section15. Regulatory information No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302, or have known CAS numbers that exceed the threshold reporting levels established by SARA Title III, Section 313. SECTION 16 - ADDITIONAL INFORMATION N/A

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : OL5550000 CHEMICAL NAME : Lysine, N(sup 6)-amidino-, L- CAS REGISTRY NUMBER : 156-86-5 LAST UPDATED : 199410 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C7-H16-N4-O2 MOLECULAR WEIGHT : 188.27 WISWESSER LINE NOTATION : QVYZ4MYZUM HEALTH HAZARD DATA ACUTE TOXICITY DATA MUTATION DATA TYPE OF TEST : DNA inhibition TEST SYSTEM : Rodent - mouse Cells - not otherwise specified DOSE/DURATION : 44500 umol/L REFERENCE : CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 42,1072,1982

安全

• 危害码 (欧洲): Xn,N,Xi
• 风险声明 (欧洲): R22:Harmful if swallowed. R36/37/38:Irritating to eyes, respiratory system and skin . R50/53:Very Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment .
• 安全声明 (欧洲): S36/37/39-S60-S61
• 危险品运输编码: UN 3077 9/PG 3
• WGK德国: 3
• RTECS号: AG3500000
• 海关编码: 29152900

上下游产品

上游产品  3
1071-37-0 70-54-2 420-04-2
下游产品  1
3105-95-1

海关

海关编码	2925290090
中文概述	2925290090 其他亚胺及其衍生物，以及它们的盐。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%
申报要素	品名, 成分含量, 用途
Summary	2925290090 other imines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%