133628-73-6

• 常用中文名：7-(β-L-天门冬氨酰氨基)-4-甲基香豆素
• 常用英文名：L-Aspartic acid β-(7-amido-4-methylcoumarin)
• CAS号：133628-73-6
• 分子式：C₁₄H₁₄N₂O₅
• 分子量：290.27100
• 相关类别： 研究领域 其他
• 发布时间：2018-12-28 19:25:48
• 更新时间：2024-01-09 18:05:08
• H-Asp(AMC)-OH是一种氨基酸衍生物,是一种荧光染料。H-Asp(AMC)-OH浓度为0.25mM时不抑制甘氨酸转运[1]。

名称

• 中文名: 7-(β-L-天门冬氨酰氨基)-4-甲基香豆素
• 英文名: L-Aspartic acid β-(7-amido-4-methylcoumarin)
• 中文别名: 7-(Β-L-天门冬氨酰氨基)-4-甲基香豆素
• 英文别名: h-asp(amc)-oh

物化性质

• 密度: 1.452g/cm3
• 沸点: 610ºC at 760mmHg
• 分子式: C₁₄H₁₄N₂O₅
• 分子量: 290.27100
• 闪点: 322.7ºC
• 精确质量: 290.09000
• PSA: 122.63000
• LogP: 1.61520
• 蒸汽压: 9.8E-16mmHg at 25°C
• 折射率: 1.651

生物活性

• 描述: H-Asp(AMC)-OH是一种氨基酸衍生物,是一种荧光染料。H-Asp(AMC)-OH浓度为0.25mM时不抑制甘氨酸转运[1]。
• 相关类别:
  研究领域 >> 其他
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. Hatanaka T, et al. Transport of amino acid-based prodrugs by the Na+- and Cl(-) -coupled amino acid transporter ATB0,+ and expression of the transporter in tissues amenable for drug delivery. J Pharmacol Exp Ther. 2004 Mar;308(3):1138-47.

MSDS

Name: L-Aspartic acid-4-(4-methyl-7-coumarinylamide) Material Safety Data Sheet Synonym: H-Asp-AM CAS: 133628-73-6 Section 1 - Chemical Product MSDS Name:L-Aspartic acid-4-(4-methyl-7-coumarinylamide) Material Safety Data Sheet Synonym:H-Asp-AM Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS CAS# Chemical Name content EINECS# 133628-73-6 L-Aspartic acid-4-(4-methyl-7-coumarin unlisted Hazard Symbols: None Listed. Risk Phrases: None Listed. Section 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW Not available. Potential Health Effects Eye: May cause eye irritation. Skin: May cause skin irritation. Ingestion: May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated. Inhalation: May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated. Chronic: Not available. Section 4 - FIRST AID MEASURES Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Ingestion: Get medical aid. Wash mouth out with water. Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Notes to Physician: Section 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Extinguishing Media: Use foam, dry chemical, or carbon dioxide. Section 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Vacuum or sweep up material and place into a suitable disposal container. Section 7 - HANDLING and STORAGE Handling: Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes. Storage: Store in a cool, dry place. Store in a tightly closed container. Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Use adequate ventilation to keep airborne concentrations low. Exposure Limits CAS# 133628-73-6: Personal Protective Equipment Eyes: Not available. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Powder Color: white Odor: Not available. pH: Not available. Vapor Pressure: Not available. Viscosity: Not available. Boiling Point: Not available. Freezing/Melting Point: Not available. Autoignition Temperature: Not available. Flash Point: Not available. Explosion Limits, lower: Not available. Explosion Limits, upper: Not available. Decomposition Temperature: Solubility in water: Specific Gravity/Density: Molecular Formula: C14H14N2O5 Molecular Weight: 290.1084 Section 10 - STABILITY AND REACTIVITY Chemical Stability: Stable under normal temperatures and pressures. Conditions to Avoid: Incompatible materials. Incompatibilities with Other Materials: Strong oxidizing agents. Hazardous Decomposition Products: Carbon monoxide, oxides of nitrogen, carbon dioxide. Hazardous Polymerization: Will not occur. Section 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 133628-73-6 unlisted. LD50/LC50: Not available. Carcinogenicity: L-Aspartic acid-4-(4-methyl-7-coumarinylamide) - Not listed by ACGIH, IARC, or NTP. Section 12 - ECOLOGICAL INFORMATION Section 13 - DISPOSAL CONSIDERATIONS Dispose of in a manner consistent with federal, state, and local regulations. Section 14 - TRANSPORT INFORMATION IATA No information available. IMO No information available. RID/ADR No information available. Section 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: Not available. Risk Phrases: Safety Phrases: WGK (Water Danger/Protection) CAS# 133628-73-6: No information available. Canada None of the chemicals in this product are listed on the DSL/NDSL list. CAS# 133628-73-6 is not listed on Canada's Ingredient Disclosure List. US FEDERAL TSCA CAS# 133628-73-6 is not listed on the TSCA inventory. It is for research and development use only. SECTION 16 - ADDITIONAL INFORMATION N/A

安全

• 个人防护装备: Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
• 安全声明 (欧洲): S22
• 危险品运输编码: NONH for all modes of transport