152-02-3

• 常用中文名：左洛啡烷
• 常用英文名：levallorphan
• CAS号：152-02-3
• 分子式：C₁₉H₂₅NO
• 分子量：283.40800
• 发布时间：2018-09-28 11:26:26
• 更新时间：2024-01-06 09:07:15

名称

• 中文名: 左洛啡烷
• 英文名: levallorphan
• 英文别名: EINECS 205-799-1; Lorfan; Levallorphane; Levalorfano [INN-Spanish]; Levallorphanum; Levallorphane [INN-French]; Levalorfano; Levallofano [DCIT]; Naloxiphan; 17-allyl-morphinan-3-ol

物化性质

• 密度: 1.14g/cm3
• 沸点: 433.5ºC at 760mmHg
• 分子式: C₁₉H₂₅NO
• 分子量: 283.40800
• 闪点: 214.2ºC
• 精确质量: 283.19400
• PSA: 23.47000
• LogP: 3.57450
• 蒸汽压: 4.02E-08mmHg at 25°C
• 折射率: 1.614
• 储存条件:

  通风低温干燥。

• 分子结构:

  1、 摩尔折射率：85.95

  2、 摩尔体积（cm³/mol）：246.6

  3、 等张比容（90.2K）：657.1

  4、 表面张力（dyne/cm）：50.4

  5、 极化率（10-24cm3）：34.07

• 计算化学:

  1.疏水参数计算参考值（XlogP）:无

  2.氢键供体数量:1

  3.氢键受体数量:2

  4.可旋转化学键数量:2

  5.互变异构体数量:3

  6.拓扑分子极性表面积23.5

  7.重原子数量:21

  8.表面电荷:0

  9.复杂度:408

  10.同位素原子数量:0

  11.确定原子立构中心数量:3

  12.不确定原子立构中心数量:0

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:1

毒性和生态

毒理学数据: 口服-大鼠LD50: 949毫克/公斤; 腹腔-小鼠LD50: 184 毫克/公斤。 CHEMICAL IDENTIFICATION RTECS NUMBER : QD0350000 CHEMICAL NAME : Morphinan-3-ol, 17-allyl-, (-)- CAS REGISTRY NUMBER : 152-02-3 LAST UPDATED : 199512 DATA ITEMS CITED : 5 MOLECULAR FORMULA : C19-H25-N-O MOLECULAR WEIGHT : 283.45 WISWESSER LINE NOTATION : T6 G666/FQ 2AF Q FX ONT&TTJ IQ O2U1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 949 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZIAQ "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973 Volume(issue)/page/year: -,-,1965 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 185 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZIAQ "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973 Volume(issue)/page/year: -,140,1973 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 184 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZIAQ "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973 Volume(issue)/page/year: -,-,1965 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 200 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ANYAA9 Annals of the New York Academy of Sciences. (New York Academy of Sciences, 2 E. 63rd St., New York, NY 10021) V.1- 1877- Volume(issue)/page/year: 281,321,1976 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4763 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 103 (estimated) No. of Female Employees: 52 (estimated)