147118-39-6

• 常用中文名：瑞舒伐他汀中间体H-2
• 常用英文名：5-Oxorosuvastatin Methyl Ester
• CAS号：147118-39-6
• 分子式：C₂₃H₂₈FN₃O₆S
• 分子量：493.548
• 发布时间：2018-09-10 21:46:17
• 更新时间：2026-07-17 17:23:02

名称

• 中文名: 瑞舒伐他汀钙中间体六
• 英文名: 7-[4-fluorophenyl]-6-isopropyl)-2-(N-Methyl-N-MethylSulfonyl amino)pyrimidine-5-yl]-(3R)-3-(terbutyldimethylsilyloxy)-5-oxo-6E-heptane acid,Methyl ester
• 中文别名: 瑞舒伐他汀钙中间体H-2; (3R)-7-[4-(4-氟苯基)-6-异丙基-2-(N-甲基-N-甲磺酰氨基)嘧啶-5-基]-3-羟基-5-氧代-(6E)-己烯酸甲酯; (+)-(3R)-7-[4-(4-氟苯基)-6-异丙基-2-(N-甲基-N-甲磺酰氨基)嘧啶-5-基]-3-羟基-5-氧代-(6E)-己烯酸甲酯; 瑞舒伐他汀钙六; 瑞舒伐他汀钙J9; 瑞舒伐他汀5-氧代酸甲酯; (+)-(3R)-7-[4-(4-氟苯基)-6-异丙基-2-(N-甲基-N-甲磺酰氨基)嘧啶-5-基; 瑞舒伐他汀钙中间体J9; 5-氧舒伐他汀甲酯; (3R,5S,6E)-7-[4-(4-氟苯基)-6-异丙基-2-(N-甲基甲磺酰基胺基-5-嘧啶)]-3-羟基-5-氧代-6-庚烯酸甲酯; (R,E)-7-(4-(4-氟苯基)-6-异丙基-2-(N-甲基甲基磺酰氨基)嘧啶-5-基)-3-羟基-5-氧代庚-6-烯酸甲酯; (+)-(3R)-7-[4-(4-氟苯基)-6-异丙基-2-(N-甲基-N-甲磺酰氨基)嘧啶-5-基]-3-羟基-5-氧; 5-氧瑞舒伐他汀钙甲酯 标准品; (R,E)-7-[4-(4-氟苯基)-6-异丙基-2-(N-甲基甲磺酰氨基)嘧啶-5-基]-3-羟基-5-氧代庚-6-烯酸
• 英文别名: Metamizole Sodium Impurity 4-d6（Metamizole Sodium Impurity D-d6）; 5-Oxorosuvastatin Methyl ester; D36-C(GLS); Methyl(+)-(3-R)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-(N-methy; Methyl (+)-(3R)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methanesulfonylamino)pyrimidin-5-yl]; (R,E)-Methyl 7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-MethylMethylsulfonaMido)pyriMidin-5-yl)-3-hydroxy-5-oxoht-6-enoate; Methyl 7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-Methyl-N-MethylsulfonylaMino)pyriMidin-5-yl]-(3R)-3-hydroxy-5-oxo-(E)-6-htenate; methyl (3R,6E)-7-[4-(4-fluorophenyl)-2-[methyl(methylsulfonyl)amino]-6-(propan-2-yl)pyrimidin-5-yl]-3-hydroxy-5-oxohept-6-enoate; Methyl (3R,6E)-7-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl}-3-hydroxy-5-oxohept-6-enoate; methyl 7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)-pyrimidin-5-yl]-(3R)-3-hydroxy-5-oxo-(E)-6-heptanate; Methyl (3R,6E)-7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3-hydroxy-5-oxo-6-htenoate; (3R,6E)-7-[4-(4-Fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3-hydroxy-5-oxo-6-htenoic acid methyl ester; methyl 7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-(3R)-3-hydroxy-5-oxo-(E)-6-heptenate; methyl 7-[4-(4-flourophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-(3R)-3-hydroxy-5-oxo-(E)-6-heptenoate; Methyl (R,E)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl]-3-hydroxy-5-oxoht-6-enoate; 6(E)-htenoate; Methyl(+)-(3-R)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-(N-Methyl-N-Methanesul fonylaMino) pyriMidin-5-y; 7-[4-fluorophenyl]-6-isopropyl)-2-(N-Methyl-N-Meth; 7-[4-(4-fluorophenyl)-6-isopropyl-2-(methylsulfonyl-methyl-amino)pyrimidin-5-yl]-3-hydroxy-5-oxo-hept-6-enoic acid methyl ester; Methyl(+)-(3-R)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-(N-methyl-N-methanesul fonylamino) pyrimidin-5-yl]-3-hydroxy-5-oxo-6(E)-htenoate; 5-Oxorosuvastatin methyl ester; Rosuvastatin 5-Oxo Acid Methyl Ester; (3R,6E)-7-[4-(4-Fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3-hydroxy-5-oxo-6-heptenoic acid methyl ester; (R,E)-Methyl 7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)-pyrimidin-5-yl)-3-hy; Methyl 7-[4-(4-FLUOROPHENYL)-6-ISO-PROPYL-2-(N-METHYL-N-METHYLSULFONYLAMINO)PYRIMIDIN-5-YL]-(3R,5R)-DIHYDROXY-(E)-6-HEPTENATE; (R,E)-Methyl 7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-MethylMethylsulfonaMido)pyriMidin-5-yl)-3-hydroxy-5-oxohept-6-enoate; Methyl(+)-(3-R)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-(N-methyl-N-methanesul fonylamino) pyrimidin-5-yl]-3-hydroxy-5-oxo-6(E)-heptenoate; Methyl (3R,6E)-7-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl}-3-hydroxy-5-oxo-6-heptenoate; methyl 7-[4-(4-flourophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)-pyrimidin-5-yl]-(3R)-3-hydroxy-5-oxo-(E)-6-heptenate; (R,E)-Methyl 7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)-pyrimidin-5-yl)-3; ZD-6; 6-Htenoic acid, 7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3-hydroxy-5-oxo-, methyl ester, (3R,6E); Methyl (+)-(3R)-7-[4-(4-fluorophenyl)- 6-isopropyl-2-(N-Methyl-NMethansulphonylaMino) pyriMidin-5-yl]-3-hydroxy-5-oxo- 6(E)-heptenoate; Methyl (+)-(3R)-7-[4-(4-fluorophenyl)- 6-isopropyl-2-(N-Methyl-NMethansulphonylaMino) pyriMidin-5-yl]-3-hydroxy-5-oxo- 6(E)-htenoate; Methyl 7-[4-(4-FLUOROPHENYL)-6-ISO-PROPYL-2-(N-METHYL-N-METHYLSULFONYLAMINO)PYRIMIDIN-5-YL] -(3R,5R)-DIHYDROXY-(E)-6-HTENATE; methyl (3R,6E)-7-[4-(4-flurophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)mino]-5-pyrimidyl]-3-hydroxy-5-oxo-6-heptenoate

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 701.7±70.0 °C at 760 mmHg
• 分子式: C₂₃H₂₈FN₃O₆S
• 分子量: 493.548
• 闪点: 378.2±35.7 °C
• 精确质量: 493.168274
• PSA: 135.14000
• LogP: 1.40
• 蒸汽压: 0.0±2.3 mmHg at 25°C
• 折射率: 1.569
• 储存条件: 2-8°C

合成路线

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