287714-41-4

• 常用中文名：罗伐他汀
• 常用英文名：Rosuvastatin
• CAS号：287714-41-4
• 分子式：C₂₂H₂₈FN₃O₆S
• 分子量：481.54
• 相关类别： 原料药 循环系统用药 抗动脉粥样硬化药
• 发布时间：2018-04-18 08:00:00
• 更新时间：2026-06-30 18:24:56
• Rosuvastatin是竞争性HMG-CoA还原酶抑制剂,IC50为11 nM。

名称

• 中文名: 罗伐他汀
• 英文名: rosuvastatin
• 中文别名: 罗伐他汀|||ZD 4522|||瑞舒伐他汀; 瑞舒伐他汀钠盐D4; (3R,5S,E)-7-(4-(4-氟苯基)-6-异丙基-2-(N-甲基甲基磺酰氨基)嘧啶-5-基)-3,5-二羟基庚-6-烯酸; 罗苏伐他汀/罗伐他汀/罗素他汀; 罗伐他汀(钙盐形式); 瑞舒伐他汀D3钠盐; 瑞舒伐他汀D4钠盐; 瑞舒伐他汀丙酮加合物; 氘代罗苏伐他汀钠盐-d3; 瑞舒伐他汀酸; 罗素他汀; 罗苏伐他汀酸; 罗伐他汀(钙酸盐); 瑞舒伐他汀杂质21; 罗伐他汀/匹伐他汀; 舒伐他汀; 瑞舒伐他汀杂质 7; 7-[4-(4-氟苯基)-6-异丙基-2-(甲基-甲磺酰-氨基)-嘧啶-5-基]-3,5-二羟基庚-6-烯酸; 瑞舒伐他汀/罗苏伐他汀游离酸; 罗苏伐他汀(瑞舒伐他汀钙); 罗苏伐他汀
• 英文别名: Rosuvastatin Calcium In House; Rosuvastatin- IP; [3H]-Rosuvastatin; Rosuvastatin //BP; 7-[4-(4-Fluorophenyl)-6-(1-methylethyl)-2-(methyl-methylsulfonyl-amino)-pyrimidin-5-yl]-3,5-dihydroxy-ht-6-enoic acid; Rosuvastatin Impurity 21; MFCD08460959; (3R,5S,E)-7-(4-(4-Fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyht-6-enoic acid; Reference source: Negwer; (3R,5S,E)-7-(4-(4-Fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyht-6-enoic acid[ZD; Rosuvastatin Methylamine Salt; CRESTOR; 6-Heptenoic acid, 7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl-d(methylsulfonyl)amino]-5-pyrimidinyl]-3,5-dihydroxy-, sodium salt, (3R,5S,6E)- (1:1); RosuvastatinQ: What is Rosuvastatin Q: What is the CAS Number of Rosuvastatin Q: What is the storage condition of Rosuvastatin Q: What e the applications of Rosuvastatin; (3R,5S,6E)-7-[4-(4-fluorophenyl)-2-(N-MethylMethanesulfonaMido)-6-(propan-2-yl)pyriMidin-5-yl]-3,5-dihydroxyht-6-enoic acid; Rosuvastatin IP; "(3R,5S)-Rosuvastatin"; Sodium (3R,5S,6E)-7-{4-(4-fluorophenyl)-6-isopropyl-2-[(H)methyl(methylsulfonyl)amino]-5-pyrimidinyl}-3,5-dihydroxy-6-heptenoate; (3R,5S,6E)-7-[4-(4-fluorophenyl)-2-(N-MethylMethanesulfonaMido)-6-(propan-2-yl)pyriMidin-5-yl]-3,5-dihydroxyhept-6-enoic acid; Rosuvastatin Acid; volume-3 compound no; ROSUVASTATIN-D3 SODIUM SALT; R-2: TERT-BUTYL-(+) 7-[4-(4-FLUOROPHENYL)-6-ISOPROPYL-2-(N-METHYLSULFONYLAMINO) PYRIMIDINE-5-YL]-(3R, 5S)-DIOXANE-(E)-6-HTENATE; 7-[4-(4-Fluorophenyl)-6-(1-methylethyl)-2-(methyl-methylsulfonyl-amino)-pyrimidin-5-yl]-3,5-dihydroxy-hept-6-enoic acid; 6-Htenoic acid, 7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3,5-dihydroxy-, (3R,5S,6E); ROSUVASTATIN

物化性质

• 密度: 1.368 g/cm3
• 沸点: 745.6ºC at 760 mmHg
• 分子式: C₂₂H₂₈FN₃O₆S
• 分子量: 481.54
• 闪点: 404.7ºC
• PSA: 152.13000
• LogP: 2.14780
• 蒸汽压: 2.38E-23mmHg at 25°C
• 折射率: 1.597
• 储存条件: 2-8°C

生物活性

• 描述: Rosuvastatin是竞争性HMG-CoA还原酶抑制剂,IC50为11 nM。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> HMG-CoA还原酶(HMGCR)
  研究领域 >> 代谢疾病
• 参考文献:

  [1]. Watanabe, M., et al., Synthesis and biological activity of methanesulfonamide pyrimidine- and N-methanesulfonyl pyrrole-substituted 3,5-dihydroxy-6-heptenoates, a novel series of HMG-CoA reductase inhibitors. Bioorg Med Chem, 1997. 5(2): p. 437-44.

  [2]. Schneck, D.W., et al., The effect of gemfibrozil on the pharmacokinetics of rosuvastatin. Clin Pharmacol Ther, 2004. 75(5): p. 455-63.

  [3]. Kim, Y.S., et al., Rosuvastatin suppresses the inflammatory responses through inhibition of c-Jun N-terminal kinase and Nuclear Factor-kappaB in endothelial cells. J Cardiovasc Pharmacol, 2007. 49(6): p. 376-83.

  [4]. Carswell, C.I., G.L. Plosker, and B. Jarvis, Rosuvastatin. Drugs, 2002. 62(14): p. 2075-85; discussion 2086-7.

  [5]. Stalker, T.J., A.M. Lefer, and R. Scalia, A new HMG-CoA reductase inhibitor, rosuvastatin, exerts anti-inflammatory effects on the microvascular endothelium: the role of mevalonic acid. Br J Pharmacol, 2001. 133(3): p. 406-12.

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