79560-20-6

• 常用中文名：萘亚胺
• 常用英文名：4-(3,4-dichlorophenyl)-N-methyl-3,4-dihydro-2H-naphthalen-1-imine
• CAS号：79560-20-6
• 分子式：C₁₇H₁₅Cl₂N
• 分子量：304.214
• 发布时间：2018-02-26 08:00:00
• 更新时间：2026-07-08 03:13:42

名称

• 中文名: 萘亚胺
• 英文名: 4-(3,4-dichlorophenyl)-N-methyl-3,4-dihydro-2H-naphthalen-1-imine
• 中文别名: 4-(3,4-二氯苯基)-1-四氢-N-甲基-1-萘亚胺 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1- naphthalenimine; 舍曲林中间体-萘亚胺; 4-(3,4-二氯苯基)-1-四氢-N-甲基-1-萘亚胺; 舍曲林杂质13; N-[4-(3,4-二氯苯基)-3,4-二氢-1(2H)-萘亚烷基]甲胺
• 英文别名: (1E)-4-(3,4-Dichlorophenyl)-N-methyl-3,4-dihydro-1(2H)-naphthalenimine; SERTRALINE HCL FORM I; 4-(3,4-Dichlorophenyl)-3,4-dihydro-1-(2H)-methanamine; (E)-4-(3,4-Dichlorophenyl)-N-methyl-3,4-dihydronaphthalen-1(2H)-imine; N-[(1E)-4-(3,4-Dichlorophenyl)-3,4-dihydronaphthalen-1(2H)-ylidene]methanamine; 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methylnaphthalen-1-amine; Sertraline Tetralone Methanamine Racemate; (1S,4S)-1-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDRO-4-(METHYLAMINO)NAPHTHALENE HYDROCHLORIDE; 4-(3,4-Dichlorophenyl)-3,4-Dihydro-N-Methyl-1-(2H)-Naphthalenimine (Schiff Base); 4-(3,4-Dichlorophenyl)-1-tetrahydro-N-methyl-1-naphthylimine; N-[(1E)-4-(3,4-Dichlorophenyl)-3,4-dihydro-1(2H)-naphthalenylidene]methanamine; Sertraline STHRC-3 Impurity; N-Methyl-4-(3,4)dichlorophenyl)-3,4-dihydro-1-(2H)-naphthalenimine; N-(4(3,4-DICHLOROPHENYL)-3,4-DIHYDRO-1(2H)NAPHTHALIDENE) METHANAMINE (INTERMEDIATE FOR SERTRALINE); Tetralone imine (Schiff base) (4-(3, 4-dichlorophenyl)-N-methyl-3, 4-dihydronaphthalen-1(2H)-imine; N-(4(3,4-dichlorophenyl)-3,4-dihydro-1(2H)naphthalidene) met; N-(4-(3,4-DICHLOROPHENYL)-3,4-DIHYDRI-1(2H)NAPHTHALIDENE)METANAMINE; N-(4(3,4-DICHLOROPHENYL)-3,4-DIHYDRO-1(2H)NAPHTHALIDENE) METHANAMINE; 4-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDRO-N-METHYL-1-NAPHTHALENIMINE 79-6; [4-(3,4-Dichlorphenyl)-3,4-Dihydro-1(2H)-Naphthalidene]Methanamine; N-[(1E)-4-(3,4-Dichlorphenyl)-3,4-dihydronaphthalen-1(2H)-yliden]methanamin; 4-(3,4-Dichlorophenyl)-3,4-dihydro-1(2H)-naphthaleneimine; N-(4-(3,4-DICHLOROPHENYL)-3,4-DIHYDRO-1(2H)-NAPHTHALENE-1-YL)-METHANAMINE; SETRALINE HCL; N-(4-(3,4-DICHLOROPHENYL)-3,4-DIHYDRO-1(2H)-NAPHTHALENE-1-ONE)-METHANAMINE; SERTRALINE HCL FORM II; (1S,4S)-4-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDRO-N-METHYL-1-NAPHTHALENAMINE HYDROCHLORIDE; Sertraline Impurity 13; 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-n-methyl-1-naphthalenimine; Methanamine, N-[4-(3,4-dichlorophenyl)-3,4-dihydro-1(2H)-naphthalenylidene]; 4-(3,4-Dichlorophenyl)-3,4-dihydro-N-methyl-1-(2H)-Napthaleneimine; N-(4(3,4-dichlorophenyl)-3,4-dihydro-1(2H)naphthalidene) methanamine; (intermediate for sertraline)

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 390.5±42.0 °C at 760 mmHg
• 熔点: 243-247ºC
• 分子式: C₁₇H₁₅Cl₂N
• 分子量: 304.214
• 闪点: 190.0±27.9 °C
• 精确质量: 303.058167
• PSA: 12.36000
• LogP: 4.79
• 外观性状: 白色至淡黄色晶体粉末
• 蒸汽压: 0.0±0.9 mmHg at 25°C
• 折射率: 1.619

安全

• 安全声明 (欧洲): S22-S24/25
• WGK德国: 3
• RTECS号: QJ0352070

合成路线

79560-19-3 74-89-5 ~95% 79560-20-6

文献：Taber, Geraldine P.; Pfisterer, David M.; Colberg, Juan C. Organic Process Research and Development, 2004 , vol. 8, # 3 p. 385 - 388

79560-19-3 ~% 79560-20-6

文献：US2003/13768 A1, ;

6284-79-3 ~% 79560-20-6

文献：Journal of Medicinal Chemistry, , vol. 27, # 11 p. 1508 - 1515

79560-17-1 ~% 79560-20-6

文献：Journal of Medicinal Chemistry, , vol. 27, # 11 p. 1508 - 1515

79560-16-0 ~% 79560-20-6

文献：Journal of Medicinal Chemistry, , vol. 27, # 11 p. 1508 - 1515

79560-18-2 ~% 79560-20-6

文献：Journal of Medicinal Chemistry, , vol. 27, # 11 p. 1508 - 1515

149620-65-5 ~% 79560-20-6

文献：Journal of Medicinal Chemistry, , vol. 27, # 11 p. 1508 - 1515

95-50-1 ~% 79560-20-6

文献：Organic Process Research and Development, , vol. 8, # 3 p. 385 - 388

90-15-3 ~% 79560-20-6

文献：Organic Process Research and Development, , vol. 8, # 3 p. 385 - 388

上下游产品

上游产品  8
79560-19-3 74-89-5 6284-79-3 79560-17-1
79560-16-0 79560-18-2 95-50-1 90-15-3
下游产品  10
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