73942-87-7

• 常用中文名：7,8-二甲氧基-1,3-二氢-2H-3-苯并氮杂卓-2-酮
• 常用英文名：7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one
• CAS号：73942-87-7
• 分子式：C₁₂H₁₃NO₃
• 分子量：219.236
• 发布时间：2018-08-04 18:03:25
• 更新时间：2026-07-04 01:15:58

名称

• 中文名: 7,8-二甲氧基-1,3-二氢-2H-3-苯并氮杂卓-2-酮
• 英文名: 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one
• 中文别名: 8-二甲氧基-1; 7,8-二甲氧基-1,3-二氢-2H-3-苯并氮杂卓-2-酮 依伐布雷定中间体; 伊伐布雷定侧链中间体6/7,8-二甲氧基-1,3-二氢-2H-3-苯并氮杂卓-2-酮; 伊伐布雷定杂质13; 盐酸伊伐布雷定侧链中间体; 盐酸伊伐布雷定侧链中间; 伊伐布雷定杂质22; 伊伐布雷定杂质73; 7,8-二甲氧基-1,3-二氢-2H-苯并氮杂草-酮; 伊伐布雷定侧链中间体6; 3-二氢-2H-3-苯并氮杂卓-2-酮; 二甲氧基-1,3-二氢-2H-3-苯并氮杂卓-2-酮; 7,8-二甲氧基-1,3-二氢-2H-苯并氮杂卓-2-酮; 7,8-二甲氧基-1H-苯并[D]氮杂卓-2(3H)-酮; 依伐布雷定中间体; 7,8-甲氧基-1,3-=氢-2H-3-苯并氮杂卓-2-酮
• 英文别名: Ivabradine Impurity 73; Hot Sell 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazin-2-one; Ivabradine Impurity 13; 7,8-diMethoxy -1,3-dihydro-2H-3-Benzazin-2-one/2H-3-Benzazin-2-one, 1,3-dihydro-7,8-diMethoxy(For Ivabradine); 3-(3-((((R)-3,4-dimethoxybicyclo[4.2.0]octa-1,2,4-trien-7-yl)methyl)(methyl)amino)propyl)-1-hydroxy-7,8-dimethoxy-4,5-dihydro-1H-benzo[d]azin-2(3H)-one; New Product 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazin-2-one; 7,8-diMethoxy-2,3-dihydro-1H-3-benzazin-2-one; 7,8-dimethoxy-1,3-dihydro-1-benzazin-2-one; 2H-3-Benzazin-2-one,1,3-dihydro-7,8-diMethoxy; 7,8-Dimethoxy-1H-benzo[d]azin-2(3H)-one>; 3-dihydro-2H-3-benzazin-2-one; 7,8 - Dimethoxy-1,3-Dichloro-2H-3-Benzazin-2-one; 1,3-Dihydro-7,8-dimethoxybenzo[d]azin-2-one; 7,8-Dimethoxy-1H-benzo[d]azin-2(3H)-one; 7, 8-dimethoxy-1, 3-dihydro-2H-3-benzoze htin-2-1, 7-dimethoxy-1, 3-dihydro-2H-3-benzoze htin-2-1; 7,8-Dimethoxy-1,3-dihydro-2H-3-benzoazo-2-one; Ivabradine Impurity 22; 7,8-dimethoxy -1,3-dihydro-2H-3-Benzazin-2-one/2H-3-Benzazin- 2-one, 1,3-dihydro-7,8-dimethoxy; 1,3-Dihydro-7,8-dimethoxy-2H-3-benzazin-2-one; 7,8-dimethoxy-1, 3-dihydro-2H-benzo[d] azin-2-one; 1,3-Dihydro-7,8-dimethoxy-2H-3-benzazepin-2-one; 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazin-2-one , 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazin-2-one; 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazin-2-one; 8-Dimethoxy-1; 1,3-Dihydro-7,8-dimethoxy-2H-3-benzazin-2-one 7,8-dimethoxy-1, 3-dihydro-2H-benzo[d] azin-2-one; 7,8-dimethoxy-1,3-dihydro-2h-3-benzoazine-2-one; 7,8-dimethoxy-1,3-dihydro-3-benzazepin-2-one; 7,8-dimethoxy-1,3-dihydro-3-benzazin-2-one

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 455.8±45.0 °C at 760 mmHg
• 熔点: 246 °C
• 分子式: C₁₂H₁₃NO₃
• 分子量: 219.236
• 闪点: 229.5±28.7 °C
• 精确质量: 219.089539
• PSA: 47.56000
• LogP: 1.80
• 外观性状: 固体;White to Almost white powder to crystal
• 蒸汽压: 0.0±1.1 mmHg at 25°C
• 折射率: 1.546
• 储存条件: 2-8°C

安全

• 危害码 (欧洲): Xi
• 海关编码: 2933790090

合成路线

73954-34-4 ~77% 73942-87-7

文献：KRKA, D. D., NOVO MESTO; BOSE, Prosenjit; SIRIPALLI, Udaya Bhaskara Rao; KANDADAI, Appan Srinivas Patent: WO2010/72409 A1, 2010 ; Location in patent: Page/Page column 17-18 ;

93-40-3 ~% 73942-87-7

文献：Journal of Medicinal Chemistry, , vol. 33, # 5 p. 1496 - 1504

10313-60-7 ~% 73942-87-7

文献：Journal of Medicinal Chemistry, , vol. 33, # 5 p. 1496 - 1504

上下游产品

上游产品  3
73954-34-4 93-40-3 10313-60-7
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海关

海关编码	2933990090
中文概述	2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%